Costel Vasile Siserman
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View article: HLA Class II Alleles and Suicidal Behavior: Evidence from a Case–Control Study
HLA Class II Alleles and Suicidal Behavior: Evidence from a Case–Control Study Open
Suicidality is a complex multifactorial phenomenon strongly associated with major depression and other psychiatric disorders. Building on evidence implicating the Major Histocompatibility Complex (MHC) in modulating the immune and inflamma…
View article: The Influence of Genetic Polymorphisms and Psychosocial Determinants on Suicidal Behaviors: A Case–Control Study of CRHR1, NTRK2, and FKBP5
The Influence of Genetic Polymorphisms and Psychosocial Determinants on Suicidal Behaviors: A Case–Control Study of CRHR1, NTRK2, and FKBP5 Open
Suicide, a major contributor to global mortality rates, especially among young patients, remains insufficiently integrated into public health initiatives despite notable progress in identifying its determinants. The prediction of suicidal …
View article: Molecular Determinants of Bone Plasticity Regeneration After Trauma: Forensic Consequences
Molecular Determinants of Bone Plasticity Regeneration After Trauma: Forensic Consequences Open
Bone tissue is one of the most remarkable examples of biological plasticity within the human body, with a high regenerative capacity and adaptation following traumatic injuries. This process is conducted through a series of complex and int…
View article: Unveiling the cause of sudden cardiac death: a macroscopic and microscopic analysis at the Institute of Forensic Medicine, Cluj-Napoca (Romania)
Unveiling the cause of sudden cardiac death: a macroscopic and microscopic analysis at the Institute of Forensic Medicine, Cluj-Napoca (Romania) Open
Sudden cardiac death (SCD) remains a critical public health problem, prompting efforts to understand its underlying causes and identify patients at risk. Despite declining cardiovascular mortality in developed nations, SCD still claims mil…
View article: A histopathological analysis of extrapulmonary lesions in fatal coronavirus disease (COVID-19)
A histopathological analysis of extrapulmonary lesions in fatal coronavirus disease (COVID-19) Open
Post-mortem analysis identified lesions associated with SARS-CoV-2 in multiple organs, highlighting the systemic nature of the virus and emphasizing the need for continued research into organ-specific damage and long-term sequelae of COVID…
View article: HLA-DR and HLA-DQ Polymorphism Correlation with Sexually Transmitted Infection Caused by Chlamydia trachomatis
HLA-DR and HLA-DQ Polymorphism Correlation with Sexually Transmitted Infection Caused by Chlamydia trachomatis Open
Background and Objectives: Chlamydia trachomatis (C. trachomatis) represents one of the most prevalent bacterial sexually transmitted diseases. This study aims to explore the relationship between HLA alleles/genotypes/haplotypes and C. tra…
View article: Immunohistochemical and Morphometric Analysis of Lung Tissue in Fatal COVID-19
Immunohistochemical and Morphometric Analysis of Lung Tissue in Fatal COVID-19 Open
The primary targets of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the lungs are type I pneumocytes, macrophages, and endothelial cells. We aimed to identify lung cells targeted by SARS-CoV-2 using viral nucleocapsid pr…
View article: COVID-19-Associated Rhino-Orbital Mucormycosis: Histological and Electron Microscopy Characteristics
COVID-19-Associated Rhino-Orbital Mucormycosis: Histological and Electron Microscopy Characteristics Open
COVID-19-associated rhino-orbital mucormycosis has become a new clinical entity. This study’s aim was to evaluate the histopathological and ultramicroscopic morphological aspects of this fungal infection. This was an observational retrospe…
View article: The Influence of HLA Polymorphisms on the Severity of COVID-19 in the Romanian Population
The Influence of HLA Polymorphisms on the Severity of COVID-19 in the Romanian Population Open
In this study, we aimed to investigate whether specific HLA alleles found in patients from Romania and the Republic of Moldova were associated with the severity of COVID-19 infection and its associated mortality. We analyzed the HLA allele…
View article: Flurona: The First Autopsied Case
Flurona: The First Autopsied Case Open
COVID-19-associated coinfections increase the patient’s risk of developing a severe form of the disease and, consequently, the risk of death. The term “flurona” was proposed to describe the coinfection of the influenza virus and SARS-CoV-2…
View article: Chlamydia trachomatis and the HLA involvement in the development of infection and disease: a narrative review
Chlamydia trachomatis and the HLA involvement in the development of infection and disease: a narrative review Open
Introduction. CT (Chlamydia trachomatis) is among the most common pathogens leading to sexually transmitted diseases. Considering the uncertain mechanism by which HLA polymorphisms influence the CT infection, reinfection, comorbidities or …
View article: Identification of Histopathological Biomarkers in Fatal Cases of Coronavirus Disease: A Study on Lung Tissue
Identification of Histopathological Biomarkers in Fatal Cases of Coronavirus Disease: A Study on Lung Tissue Open
We aimed to evaluate the primary lung postmortem macro- and microscopic biomarkers and factors associated with diffuse alveolar damage in patients with fatal coronavirus (COVID-19). We retrospectively analyzed lung tissue collected from au…
View article: Histopathological Lung Findings in COVID-19 B.1.617.2 SARS-CoV-2 Delta Variant
Histopathological Lung Findings in COVID-19 B.1.617.2 SARS-CoV-2 Delta Variant Open
Background: The Delta variant (Pango lineage B.1.617.2) is one of the most significant and aggressive variants of SARS-CoV-2. To the best of our knowledge, this is the first paper specifically studying pulmonary morphopathology in COVID-19…
View article: Asymptomatic Esophageal Necrosis in a Patient with Recent COVID-19: The First Case Diagnosed through Autopsy
Asymptomatic Esophageal Necrosis in a Patient with Recent COVID-19: The First Case Diagnosed through Autopsy Open
Acute esophageal necrosis is a rare condition, characterized by a distinctive endoscopic/necropsic image–circumferential black area of the esophagus. This paper presents a case of a 78-year-old patient with recent history of a severe form …
View article:  A Review of the Psychological Effects of the Spread of the COVID-19 Disease on the Mental Health of the Community
A Review of the Psychological Effects of the Spread of the COVID-19 Disease on the Mental Health of the Community Open
Infectious illness COVID-19, which was caused by a brand-new coronavirus and was identified by the World Health Organization (WHO) as , was reported to be spreading in the Chinese city of Wuhan at the end of December 2019.Due to its rapid …
View article: Medico-Legal Approach to Incestuous Sexual Orientation in Men
Medico-Legal Approach to Incestuous Sexual Orientation in Men Open
The present work addresses the controversial issue of incest by men.We sought to highlight that the incestuous tendency in men becomes a sexual preference that isn't determined directly by the existence of borderline or other personality t…
View article: Association of HLA class II alleles with suicidal behavior in a Transylvanian population
Association of HLA class II alleles with suicidal behavior in a Transylvanian population Open
Background : Suicide is a complex phenomenon determined by the interaction of various risk factors. The Major Histocompatibility Complex is the most polymorphic gene cluster of the entire human genome, being linked to both the regulation o…
View article: The assessment of risk factors for brainstem injuries and supratentorial brain injuries in patients with traumatic brain injury
The assessment of risk factors for brainstem injuries and supratentorial brain injuries in patients with traumatic brain injury Open
Traumatic brain injury (TBI) is an important cause of death with a significant worldwide percentage. In the United States, there are approximately 2.8 million TBIs yearly with 250,000 hospitalized patients and 50,000 TBI-related deaths. Ev…
View article: The Influence of HLA Alleles on the Affective Distress Profile
The Influence of HLA Alleles on the Affective Distress Profile Open
(1) Background: Affective distress can be triggered by aggressive stimuli with an unfavorable role for the individual. Some of the factors that lead to the development and evolution of a mental disorder can be genetic. The aim of this stud…
View article: Fatal Form of COVID-19 in a Young Male Bodybuilder Anabolic Steroid Using: The First Autopsied Case
Fatal Form of COVID-19 in a Young Male Bodybuilder Anabolic Steroid Using: The First Autopsied Case Open
We report the case of a 34-year-old male patient, a bodybuilding trainer and user of anabolic androgenic steroids (AASs) for 16 years. He was found in cardio-respiratory arrest in his home. By performing a medico-legal autopsy, a severe fo…
View article: Determinants of Suicide Ideation in the Romanian Population
Determinants of Suicide Ideation in the Romanian Population Open
Background: Suicide ideation and behaviors are directly linked to the risk of death by suicide. In Romania, as well as worldwide, increased suicide rates were observed in the recent past, more so in the context of the COVID-19 pandemic. Th…