Courtney J. Mercadante
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View article: Studies of Slc30a10 Deficiency in Mice Reveal That Intestinal Iron Transporters Dmt1 and Ferroportin Transport Manganese
Studies of Slc30a10 Deficiency in Mice Reveal That Intestinal Iron Transporters Dmt1 and Ferroportin Transport Manganese Open
Aberrant absorption contributes prominently to SLC30A10 deficiency, a disease previously attributed to impaired excretion, and is dependent upon intestinal Dmt1 and ferroportin and exacerbated by loss of intestinal Slc30a10. This work expa…
View article: Manganese transporter SLC30A10 and iron transporters SLC40A1 and SLC11A2 impact dietary manganese absorption
Manganese transporter SLC30A10 and iron transporters SLC40A1 and SLC11A2 impact dietary manganese absorption Open
SLC30A10 deficiency is a disease of severe manganese excess attributed to loss of SLC30A10-dependent manganese excretion via the gastrointestinal tract. Patients develop dystonia, cirrhosis, and polycythemia. They are treated with chelator…
View article: Hepatic HIF2 is a key determinant of manganese excess and polycythemia in SLC30A10 deficiency
Hepatic HIF2 is a key determinant of manganese excess and polycythemia in SLC30A10 deficiency Open
Manganese is an essential yet potentially toxic metal. Initially reported in 2012, mutations in SLC30A10 are the first known inherited cause of manganese excess. SLC30A10 is an apical membrane protein that exports manganese from hepatocyte…
View article: SAR443809: a selective inhibitor of the complement alternative pathway, targeting complement factor Bb
SAR443809: a selective inhibitor of the complement alternative pathway, targeting complement factor Bb Open
Dysregulated activation of the complement system is implicated in the onset or progression of several diseases. Most clinical-stage complement inhibitors target the inactive complement proteins present at high concentrations in plasma, whi…
View article: Hypoxia-inducible factor 2 is a key determinant of manganese excess and polycythemia in SLC30A10 deficiency
Hypoxia-inducible factor 2 is a key determinant of manganese excess and polycythemia in SLC30A10 deficiency Open
Manganese is an essential yet potentially toxic metal. Initially reported in 2012, mutations in SLC30A10 are the first known inherited cause of manganese excess. SLC30A10 is an apical membrane transport protein that exports manganese from …
View article: Characterization of in vitro models of SLC30A10 deficiency
Characterization of in vitro models of SLC30A10 deficiency Open
View article: Manganese transporter Slc30a10 controls physiological manganese excretion and toxicity
Manganese transporter Slc30a10 controls physiological manganese excretion and toxicity Open
Manganese (Mn), an essential metal and nutrient, is toxic in excess. Toxicity classically results from inhalational exposures in individuals who work in industrial settings. The first known disease of inherited Mn excess, identified in 201…
View article: Gastrointestinal iron excretion and reversal of iron excess in a mouse model of inherited iron excess
Gastrointestinal iron excretion and reversal of iron excess in a mouse model of inherited iron excess Open
The current paradigm in the field of mammalian iron biology states that body iron levels are determined by dietary iron absorption, not by iron excretion. Iron absorption is a highly regulated process influenced by iron levels and other fa…
View article: Interactions of manganese with iron, zinc, and copper in neonatal C57BL/6J and parkin mice following developmental oral manganese exposure
Interactions of manganese with iron, zinc, and copper in neonatal C57BL/6J and parkin mice following developmental oral manganese exposure Open
High dose manganese (Mn) exposure can result in changes in tissue concentrations of other essential metals due to Mn-induced alterations in metal absorption and competition for metal transporters and regulatory proteins. We evaluated respo…
View article: Neonatal C57BL/6J and parkin mice respond differently following developmental manganese exposure: Result of a high dose pilot study
Neonatal C57BL/6J and parkin mice respond differently following developmental manganese exposure: Result of a high dose pilot study Open
View article: The effect of high dose oral manganese exposure on copper, iron and zinc levels in rats
The effect of high dose oral manganese exposure on copper, iron and zinc levels in rats Open
View article: Proteomic identification of novel cytoskeletal proteins associated with TbPLK, an essential regulator of cell morphogenesis in<i>Trypanosoma brucei</i>
Proteomic identification of novel cytoskeletal proteins associated with TbPLK, an essential regulator of cell morphogenesis in<i>Trypanosoma brucei</i> Open
Trypanosoma brucei is the causative agent of African sleeping sickness, a devastating disease endemic to sub-Saharan Africa with few effective treatment options. The parasite is highly polarized, including a single flagellum that is nuclea…