Courtney M. Fernandez-Petty

COVID-19 Causes Ciliary Dysfunction as Demonstrated by Human Intranasal Micro-Optical Coherence Tomography Imaging Open

Kadambari Vijaykumar, Hui Min Leung, Amilcar Barrios, Courtney M. Fernandez-Petty, George M. Solomon , et al. · 2023

SNSP113 (PAAG) improves mucociliary transport and lung pathology in the Scnn1b-Tg murine model of CF lung disease Open

Elex S. Harris, Lea Novak, Courtney M. Fernandez-Petty, Natalie R. Lindgren, S Baker , et al. · 2023

Mucociliary transport deficiency and disease progression in Syrian hamsters with SARS-CoV-2 infection Open

Qian Li, Kadambari Vijaykumar, Scott E. Phillips, Shah S. Hussain, Nha Van Huynh , et al. · 2023

Substantial clinical evidence supports the notion that ciliary function in the airways is important in COVID-19 pathogenesis. Although ciliary damage has been observed in both in vitro and in vivo models, the extent or nature of impairment…

COVID-19 Causes Ciliary Dysfunction as Demonstrated by Human Intranasal Micro-Optical Coherence Tomography Imaging Open

Kadambari Vijaykumar, Hui Min Leung, Amilcar Barrios, Courtney M. Fernandez-Petty, George M. Solomon , et al. · 2022

Severe acute respiratory syndrome coronavirus (SARS-CoV-2), causative agent of coronavirus disease 2019 (COVID-19), binds via ACE2 receptors, highly expressed in ciliated cells of the nasal epithelium. Micro-optical coherence tomography (μ…

Muc5b Contributes to Mucus Abnormality in Rat Models of Cystic Fibrosis Open

Johnathan D. Keith, A. Henderson, Courtney M. Fernandez-Petty, Joy M. Davis, Ashley M. Oden , et al. · 2022

Cystic fibrosis (CF) airway disease is characterized by excessive and accumulative mucus in the airways. Mucociliary clearance becomes defective as mucus secretions become hyperconcentrated and viscosity increases. The CFTR-knockout (KO) r…

Mucociliary Transport Deficiency and Disease Progression in Syrian Hamsters with SARS-CoV-2 Infection Open

Qian Li, Kadambari Vijaykumar, Scott E Philips, Shah S. Hussain, Van Huynh , et al. · 2022

Substantial clinical evidence supports the notion that ciliary function in the airways plays an important role in COVID-19 pathogenesis. Although ciliary damage has been observed in both in vitro and in vivo models, consequent impaired muc…

Ivacaftor Reverses Airway Mucus Abnormalities in a Rat Model Harboring a Humanized G551D-CFTR Open

Susan E. Birket, Joy M. Davis, Courtney M. Fernandez-Petty, A. Henderson, Ashley M. Oden , et al. · 2020

Rationale: Animal models have been highly informative for understanding the characteristics, onset, and progression of cystic fibrosis (CF) lung disease. In particular, the CFTR^-/- rat has revealed insights into the airwa…

Intranasal micro-optical coherence tomography imaging for cystic fibrosis studies Open

Hui Min Leung, Susan E. Birket, Chulho Hyun, Timothy N. Ford, Dongyao Cui , et al. · 2019

Micro-optical coherence tomography with an intranasal imaging probe detects defects in the mucociliary transport of people with cystic fibrosis.

A glycopolymer improves vascoelasticity and mucociliary transport of abnormal cystic fibrosis mucus Open

Courtney M. Fernandez-Petty, Gareth W. Hughes, Hannah L. Bowers, J. Devin B. Watson, Bradley H. Rosen , et al. · 2019

Cystic fibrosis (CF) is characterized by increased mucus viscosity and delayed mucociliary clearance that contributes to progressive decline of lung function. Mucus in the respiratory and GI tract is excessively adhesive in the presence of…

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