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View article: Innate Immune Sensing of Adeno-Associated Virus Vectors
Innate Immune Sensing of Adeno-Associated Virus Vectors Open
Adeno-associated virus (AAV) based viral vectors are widely used in human gene therapy and form the basis of approved treatments for several genetic diseases. Immune responses to vector and transgene products, however, substantially compli…
View article: Distinct functions and transcriptional signatures in orally induced regulatory T cell populations
Distinct functions and transcriptional signatures in orally induced regulatory T cell populations Open
Oral administration of antigen induces regulatory T cells (Treg) that can not only control local immune responses in the small intestine, but also traffic to the central immune system to deliver systemic suppression. Employing murine model…
View article: Supplementary Legends from SLAMF6 as a Regulator of Exhausted CD8<sup>+</sup> T Cells in Cancer
Supplementary Legends from SLAMF6 as a Regulator of Exhausted CD8<sup>+</sup> T Cells in Cancer Open
Supplementary Figure legends
View article: Supplementary Tables and Figures from SLAMF6 as a Regulator of Exhausted CD8<sup>+</sup> T Cells in Cancer
Supplementary Tables and Figures from SLAMF6 as a Regulator of Exhausted CD8<sup>+</sup> T Cells in Cancer Open
Supplementary Tables and Figures
View article: Supplementary Tables and Figures from SLAMF6 as a Regulator of Exhausted CD8<sup>+</sup> T Cells in Cancer
Supplementary Tables and Figures from SLAMF6 as a Regulator of Exhausted CD8<sup>+</sup> T Cells in Cancer Open
Supplementary Tables and Figures
View article: Data from SLAMF6 as a Regulator of Exhausted CD8<sup>+</sup> T Cells in Cancer
Data from SLAMF6 as a Regulator of Exhausted CD8<sup>+</sup> T Cells in Cancer Open
The tumor microenvironment in leukemia and solid tumors induces a shift of activated CD8+ cytotoxic T cells to an exhausted state, characterized by loss of proliferative capacity and impaired immunologic synapse formation. Efficient strate…
View article: Data from SLAMF6 as a Regulator of Exhausted CD8<sup>+</sup> T Cells in Cancer
Data from SLAMF6 as a Regulator of Exhausted CD8<sup>+</sup> T Cells in Cancer Open
The tumor microenvironment in leukemia and solid tumors induces a shift of activated CD8+ cytotoxic T cells to an exhausted state, characterized by loss of proliferative capacity and impaired immunologic synapse formation. Efficient strate…
View article: Supplementary Legends from SLAMF6 as a Regulator of Exhausted CD8<sup>+</sup> T Cells in Cancer
Supplementary Legends from SLAMF6 as a Regulator of Exhausted CD8<sup>+</sup> T Cells in Cancer Open
Supplementary Figure legends
View article: Characterization of Ly108-H1 Signaling Reveals Ly108-3 Expression and Additional Strain-Specific Differences in Lupus Prone Mice
Characterization of Ly108-H1 Signaling Reveals Ly108-3 Expression and Additional Strain-Specific Differences in Lupus Prone Mice Open
Ly108 (SLAMF6) is a homophilic cell surface molecule that binds SLAM-associated protein (SAP), an intracellular adapter protein that modulates humoral immune responses. Furthermore, Ly108 is crucial for the development of natural killer T …
View article: SLAMF8 Downregulates Mouse Macrophage Microbicidal Mechanisms via PI3K Pathways
SLAMF8 Downregulates Mouse Macrophage Microbicidal Mechanisms via PI3K Pathways Open
Signaling lymphocytic activation molecule family 8 (SLAMF8) is involved in the negative modulation of NADPH oxidase activation. However, the impact of SLAMF8 downregulation on macrophage functionality and the microbicide mechanism remains …
View article: Role of Small Intestine and Gut Microbiome in Plant-Based Oral Tolerance for Hemophilia
Role of Small Intestine and Gut Microbiome in Plant-Based Oral Tolerance for Hemophilia Open
Fusion proteins, which consist of factor VIII or factor IX and the transmucosal carrier cholera toxin subunit B, expressed in chloroplasts and bioencapsulated within plant cells, initiate tolerogenic immune responses in the intestine when …
View article: SLAMF6 as a Regulator of Exhausted CD8+ T Cells in Cancer
SLAMF6 as a Regulator of Exhausted CD8+ T Cells in Cancer Open
The tumor microenvironment in leukemia and solid tumors induces a shift of activated CD8+ cytotoxic T cells to an exhausted state, characterized by loss of proliferative capacity and impaired immunologic synapse formation. Efficient strate…
View article: The Checkpoint Regulator SLAMF3 Preferentially Prevents Expansion of Auto-Reactive B Cells Generated by Graft-vs.-Host Disease
The Checkpoint Regulator SLAMF3 Preferentially Prevents Expansion of Auto-Reactive B Cells Generated by Graft-vs.-Host Disease Open
Absence of the mouse cell surface receptor SLAMF3 in SLAMF3-/- mice suggested that this receptor negatively regulates B cell homeostasis by modulating activation thresholds of B cell subsets. Here, we examine whether anti-SLAMF3 affects bo…
View article: The Checkpoint Regulator SLAMF3 Preferentially Prevents Expansion of Auto-Reactive B Cells Generated by Graft-vs.-Host Disease
The Checkpoint Regulator SLAMF3 Preferentially Prevents Expansion of Auto-Reactive B Cells Generated by Graft-vs.-Host Disease Open
Absence of the mouse cell surface receptor SLAMF3 in SLAMF3-/- mice suggested that this receptor negatively regulates B cell homeostasis by modulating activation thresholds of B cell subsets. Here, we examine whether anti-SLAMF3 affects bo…
View article: Reprogrammed CD4+ T Cells That Express FoxP3+ Control Inhibitory Antibody Formation in Hemophilia A Mice
Reprogrammed CD4+ T Cells That Express FoxP3+ Control Inhibitory Antibody Formation in Hemophilia A Mice Open
Coagulation Factor VIII (FVIII) replacement therapy in hemophilia A patients is complicated by the development of inhibitory antibodies, which often render the treatment ineffective. Previous studies demonstrated a strong correlation betwe…
View article: 2B4 Mediates Inhibition of CD8+ T Cell Responses via Attenuation of Glycolysis and Cell Division
2B4 Mediates Inhibition of CD8+ T Cell Responses via Attenuation of Glycolysis and Cell Division Open
We recently showed that 2B4 expression on memory T cells in human renal transplant recipients was associated with reduced rates of rejection. To investigate whether 2B4 functionally underlies graft acceptance during transplantation, we est…
View article: Gene Therapy With Regulatory T Cells: A Beneficial Alliance
Gene Therapy With Regulatory T Cells: A Beneficial Alliance Open
Gene therapy aims to replace a defective or a deficient protein at therapeutic or curative levels. Improved vector designs have enhanced safety, efficacy, and delivery, with potential for lasting treatment. However, innate and adaptive imm…
View article: SLAMF1 is required for TLR4-mediated TRAM-TRIF–dependent signaling in human macrophages
SLAMF1 is required for TLR4-mediated TRAM-TRIF–dependent signaling in human macrophages Open
Signaling lymphocytic activation molecule family 1 (SLAMF1) is an Ig-like receptor and a costimulatory molecule that initiates signal transduction networks in a variety of immune cells. In this study, we report that SLAMF1 is required for …
View article: Ly9 (SLAMF3) receptor differentially regulates iNKT cell development and activation in mice
Ly9 (SLAMF3) receptor differentially regulates iNKT cell development and activation in mice Open
Invariant natural killer T (iNKT) cells develop into three subsets (NKT1, NKT2, and NKT17) expressing a distinct transcription factor profile, which regulates cytokine secretion upon activation. iNKT cell development in the thymus is modul…
View article: Cutting Edge: 2B4-Mediated Coinhibition of CD4+ T Cells Underlies Mortality in Experimental Sepsis
Cutting Edge: 2B4-Mediated Coinhibition of CD4+ T Cells Underlies Mortality in Experimental Sepsis Open
Sepsis is a leading cause of death in the United States, but the mechanisms underlying sepsis-induced immune dysregulation remain poorly understood. 2B4 (CD244, SLAM4) is a cosignaling molecule expressed predominantly on NK cells and memor…
View article: IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization
IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization Open
Atopic dermatitis (AD) is a Th2-dominated inflammatory skin disease characterized by epidermal thickening. Serum levels of IL-22, a cytokine known to induce keratinocyte proliferation, are elevated in AD, and Th22 cells infiltrate AD skin …
View article: Inhibition of SHP2 ameliorates the pathogenesis of systemic lupus erythematosus
Inhibition of SHP2 ameliorates the pathogenesis of systemic lupus erythematosus Open
Systemic lupus erythematosus (SLE) is a devastating multisystemic autoimmune disorder. However, the molecular mechanisms underlying its pathogenesis remain elusive. Some patients with Noonan syndrome, a congenital disorder predominantly ca…
View article: Decreased SAP Expression in T Cells from Patients with Systemic Lupus Erythematosus Contributes to Early Signaling Abnormalities and Reduced IL-2 Production
Decreased SAP Expression in T Cells from Patients with Systemic Lupus Erythematosus Contributes to Early Signaling Abnormalities and Reduced IL-2 Production Open
T cells from patients with systemic lupus erythematosus (SLE) display a number of abnormalities, including increased early signaling events following engagement of the TCR. Signaling lymphocytic activation molecule family cell surface rece…
View article: A combination of an anti-SLAMF6 antibody and ibrutinib efficiently abrogates expansion of chronic lymphocytic leukemia cells
A combination of an anti-SLAMF6 antibody and ibrutinib efficiently abrogates expansion of chronic lymphocytic leukemia cells Open
The signaling lymphocyte activation molecule family [SLAMF] of cell surface receptors partakes in both the development of several immunocyte lineages and innate and adaptive immune responses in humans and mice. For instance, the homophilic…