Explanipedia

High prevalence of Clostridioides difficile in retail garden products from two Australian states Open

Jessica M. Chisholm, Craig A. Bell, Molly Lattin, Su‐Chen Lim, Simon Reid , et al. · 2025

A Standardized Protocol to Investigate Trans- Endothelial Trafficking in Zebrafish: Nano-bio Interactions of PEG-based Nanoparticles in Live Vasculature Open

Ye‐Wheen Lim, Craig A. Bell, Nicholas L. Fletcher, Nicholas D. Condon, Dewan Taslima Akhter , et al. · 2025

Trans-endothelial transport of nanoparticles remains poorly characterized in live organisms. The zebrafish is a well-established model for direct in vivo imaging; however, standardized controls are not consistently applied across studies. …

Immune-modulating nanomedicines for enhanced drug delivery to non-small-cell lung cancer Open

Feifei Liu, Christopher B. Howard, Pie Huda, Nicholas L. Fletcher, Craig A. Bell , et al. · 2025

Immune-modulating peptides have shown potential as novel immune-stimulating agents which enhance the secretion of anticancer cytokines in vitro. However, fast clearance from blood hampers the ability of such peptides to accumulate in the t…

Material Trends and Clinical Costings in Systematically Identified CDER‐Approved Nanomedicines Open

Thomas Ryan Jarrett, Lisette Pregelj, Craig A. Bell, Nicholas L. Fletcher, Kristofer J. Thurecht · 2024

Research into mechanisms and potential applications of nanomaterials in medicine has expanded steadily in recent decades, with increasing translational focus. Development costs, including for clinical trials, are often cited as factors lim…

Click‐on Antibody Fragments for Customisable Targeted Nanomedicines – Site‐specific Tetrazine and Azide Functionalisation through Non‐canonical Amino Acid incorporation Open

Pie Huda, James Humphries, Nicholas L. Fletcher, Christopher B. Howard, Kristofer J. Thurecht , et al. · 2023

Protein functionalisation for the development of imaging agents and antibody drug conjugates still often relies on statistical amidation of the protein through accessible lysine and cysteine residues, requiring protein to protein conjugati…

Emerging roles for diguanylate cyclase during the evolution of soma in dictyostelia Open

Yoshinori Kawabe, Qingyou Du, Takaaki B. Narita, Craig A. Bell, Christina Schilde , et al. · 2023

Exploring the impact of severity in hepatic fibrosis disease on the intrahepatic distribution of novel biodegradable nanoparticles targeted towards different disease biomarkers Open

Arunpandian Balaji, Craig A. Bell, Zachary H. Houston, Kim R. Bridle, Berit Genz , et al. · 2023

Nanoparticle-based drug delivery systems (DDS) have shown promising results in reversing hepatic fibrosis, a common pathological basis of chronic liver diseases (CLDs), in preclinical animal models. However, none of these nanoparticle form…

Additional file 1 of Emerging roles for diguanylate cyclase during the evolution of soma in dictyostelia Open

Yoshinori Kawabe, Qingyou Du, Takaaki B. Narita, Craig A. Bell, Christina Schilde , et al. · 2023

Supplementary Material 1

Probing the Biocompatibility and Immune Cell Association of Chiral, Water-Soluble, Bottlebrush Poly(2-oxazoline)s Open

David Pizzi, James Humphries, Joshua P. Morrow, Ayaat Mahmoud, Nicholas L. Fletcher , et al. · 2022

Poly(2-oxazoline)s (POx) have received substantial attention as poly(ethylene glycol) (PEG) alternatives in the biomedical field due to their biocompatibility, high functionality, and ease of synthesis. While POx have demonstrated strong p…

Cyanine-5-Driven Behaviours of Hyperbranched Polymers Designed for Therapeutic Delivery Are Cell-Type Specific and Correlated with Polar Lipid Distribution in Membranes Open

Joshua D. Simpson, Denni Currin-Ross, Gayathri R. Ediriweera, Horst Joachim Schirra, Nicholas L. Fletcher , et al. · 2021

The ability to predict the behaviour of polymeric nanomedicines can often be obfuscated by subtle modifications to the corona structure, such as incorporation of fluorophores or other entities. However, these interactions provide an intrig…

Fluorophore Selection and Incorporation Contribute to Permeation and Distribution Behaviors of Hyperbranched Polymers in Multi-Cellular Tumor Spheroids and Xenograft Tumor Models Open

Joshua D. Simpson, Patricia Monteiro, Gayathri R. Ediriweera, Amber R. Prior, Stefan Sonderegger , et al. · 2021

Improving our understanding of how design choices in materials synthesis impact biological outcomes is of critical importance in the development of nanomedicines. Here, we show that fluorophore labeling of polymer nanomedicine candidates s…

Concomitant control of mechanical properties and degradation in resorbable elastomer-like materials using stereochemistry and stoichiometry for soft tissue engineering Open

Mary Beth Wandel, Craig A. Bell, Jiayi Yu, Maria C. Arno, Nathan Z. Dreger , et al. · 2021

Thermally-induced hyperbranching of bromine-containing polyesters by insertion of <i>in situ</i> generated chain-end carbenes Open

Panagiotis Bexis, Maria C. Arno, Craig A. Bell, A. W. Thomas, Andrew P. Dove · 2021

Thermolysis of a diazirine end group of a Br-functional PCL leads to carbene generation and subsequent hyperbranched polymers. Grafting of a hydrophilic PEG yields amphiphilic polymers which self-assemble into spherical core–shell nanopart…

Understanding the role of colon-specific microparticles based on retrograded starch/pectin in the delivery of chitosan nanoparticles along the gastrointestinal tract Open

Aline Martins dos Santos, Andréía Bagliotti Meneguin, Dewan Taslima Akhter, Nicholas L. Fletcher, Zachary H. Houston , et al. · 2020

Person-Specific Biomolecular Coronas Modulate Nanoparticle Interactions with Immune Cells in Human Blood Open

Yi Ju, Hannah G. Kelly, Laura F. Dagley, Arnold Reynaldi, Timothy E. Schlub , et al. · 2020

When nanoparticles interact with human blood, a multitude of plasma components adsorb onto the surface of the nanoparticles, forming a biomolecular corona. Corona composition is known to be influenced by the chemical composition of nanopar…

Controlling the Biological Fate of Micellar Nanoparticles: Balancing Stealth and Targeting Open

Amal J. Sivaram, Andri Wardiana, Sheilajen Alcântara, Stefan Sonderegger, Nicholas L. Fletcher , et al. · 2020

Integrating nanomaterials with biological entities has led to the development of diagnostic tools and biotechnology-derived therapeutic products. However, to optimize the design of these hybrid bionanomaterials, it is essential to understa…

Effect of Chain‐End Chemistries on the Efficiency of Coupling Antibodies to Polymers Using Unnatural Amino Acids Open

Amal J. Sivaram, Andri Wardiana, S. S. Hema Preethi, Adrian V. Fuchs, Christopher B. Howard , et al. · 2020

Novel conjugates that incorporate strategies for increasing the therapeutic payload, such as targeted polymeric delivery vehicles, have great potential in overcoming limitations of conventional antibody therapies that often exhibit immunog…

Tuning of the Aggregation Behavior of Fluorinated Polymeric Nanoparticles for Improved Therapeutic Efficacy Open

Cheng Zhang, Tianqing Liu, Wenqian Wang, Craig A. Bell, Yanxiao Han , et al. · 2020

Incorporation of fluorinated moieties in polymeric nanoparticles has been shown in many instances to increase their uptake by living cells and, hence, has proven to be a useful approach to enhancing delivery to cells. However, it remains u…

Targeted and modular architectural polymers employing bioorthogonal chemistry for quantitative therapeutic delivery Open

Gayathri R. Ediriweera, Joshua D. Simpson, Adrian V. Fuchs, T.K. Venkatachalam, Matthias Van De Walle , et al. · 2020

There remain several key challenges to existing therapeutic systems for cancer therapy, such as quantitatively determining the true, tissue-specific drug release profile in vivo, as well as reducing side-effects for an increased standard o…

EphA3 Pay-Loaded Antibody Therapeutics for the Treatment of Glioblastoma Open

Carolin Offenhäuser, Fares Al‐Ejeh, Simon Puttick, Kathleen S. Ensbey, Zara C. Bruce , et al. · 2018

The EphA3 receptor has recently emerged as a functional tumour-specific therapeutic target in glioblastoma (GBM). EphA3 is significantly elevated in recurrent disease, is most highly expressed on glioma stem cells (GSCs), and has a functio…

Consequences of Skipping First Year Composition: Mapping Student Writing from High School to the Academic Disciplines Open

Craig A. Bell · 2017

Research in writing studies has focused on students who make the traditional transition from high school to first year composition, to the entry level discipline specific courses in their chosen majors (Wardle, 2007, 2009; Sommers and Salt…

Independent Control of Elastomer Properties through Stereocontrolled Synthesis Open

Craig A. Bell, Jiayi Yu, Ian A. Barker, Vinh X. Truong, Zhen Cao , et al. · 2016

In most synthetic elastomers, changing the physical properties by monomer choice also results in a change to the crystallinity of the material, which manifests through alteration of its mechanical performance. Using organocatalyzed stereos…

Independent Control of Elastomer Properties through Stereocontrolled Synthesis Open

Craig A. Bell, Jiayi Yu, Ian A. Barker, Vinh X. Truong, Zhen Cao , et al. · 2016

In most synthetic elastomers, changing the physical properties by monomer choice also results in a change to the crystallinity of the material, which manifests through alteration of its mechanical performance. Using organocatalyzed stereos…

Functional Degradable Polymers by Radical Ring-Opening Copolymerization of MDO and Vinyl Bromobutanoate: Synthesis, Degradability and Post-Polymerization Modification Open

Guillaume G. Hedir, Craig A. Bell, Rachel K. O’Reilly, Andrew P. Dove · 2015

The synthesis of vinyl bromobutanoate (VBr), a new vinyl acetate monomer derivative obtained by the palladium-catalyzed vinyl exchange reaction between vinyl acetate (VAc) and 4-bromobutyric acid is reported. The homopolymerization of this…

Controlling the synthesis of degradable vinyl polymers by xanthate-mediated polymerization Open

Craig A. Bell, Guillaume G. Hedir, Rachel K. O’Reilly, Andrew P. Dove · 2015

The copolymerization of vinyl acetate (VAc) and 2-methylene-1,3-dioxepane (MDO), as well as the homopolymerization of MDO in the presence of a p-methoxyphenyl xanthate chain transfer agent (CTA) is reported and comparison of the homopolyme…

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