Craig B. Langman
YOU?
Author Swipe
View article: Nephrocalcinosis and kidney function in children and adults with X-linked hypophosphatemia: baseline results from a large longitudinal study
Nephrocalcinosis and kidney function in children and adults with X-linked hypophosphatemia: baseline results from a large longitudinal study Open
Background In patients with X-linked hypophosphatemia (XLH), conventional therapy with oral phosphate salts and active vitamin D has been associated with nephrocalcinosis. However, the nature of the relationships among XLH, its treatment, …
View article: Structural and non-coding variants increase the diagnostic yield of clinical whole genome sequencing for rare diseases
Structural and non-coding variants increase the diagnostic yield of clinical whole genome sequencing for rare diseases Open
View article: Fertility Management in Cystinosis: A Clinical Perspective
Fertility Management in Cystinosis: A Clinical Perspective Open
Cystinosis is a rare, inherited, lysosomal storage disorder characterized by the progressive accumulation of intralysosomal cystine and subsequent organ and tissue damage. The kidneys are the first and most severely impacted organ. Althoug…
View article: Persistent Increase in Serum Ferritin Levels despite Converting to Permanent Vascular Access in Pediatric Hemodialysis Patients: Pediatric Nephrology Research Consortium Study
Persistent Increase in Serum Ferritin Levels despite Converting to Permanent Vascular Access in Pediatric Hemodialysis Patients: Pediatric Nephrology Research Consortium Study Open
Our objective was to examine serum ferritin trends after conversion to permanent vascular access (PVA) among children who started hemodialysis (HD) using tunneled cuffed catheters (TCC). Retrospective chart reviews were completed on 98 sub…
View article: Long-term clinical benefits of delayed-release cysteamine bitartrate capsules in patients with nephropathic cystinosis (response to “A comparison of immediate release and delayed release cysteamine in 17 patients with nephropathic cystinosis”)
Long-term clinical benefits of delayed-release cysteamine bitartrate capsules in patients with nephropathic cystinosis (response to “A comparison of immediate release and delayed release cysteamine in 17 patients with nephropathic cystinosis”) Open
View article: End Point Considerations for Clinical Trials in Enteric Hyperoxaluria
End Point Considerations for Clinical Trials in Enteric Hyperoxaluria Open
Enteric hyperoxaluria is a medical condition characterized by elevated urinary oxalate excretion due to increased gastrointestinal oxalate absorption. Causative features include fat malabsorption and/or increased intestinal permeability to…
View article: Adherence to the 2017 Clinical Practice Guidelines for Pediatric Hypertension in Safety-Net Clinics
Adherence to the 2017 Clinical Practice Guidelines for Pediatric Hypertension in Safety-Net Clinics Open
Importance The 2017 Clinical Practice Guideline (CPG) for the diagnosis and management of pediatric hypertension (PHTN) categorizes a greater proportion of children with elevated blood pressure and PHTN, yet several barriers to CPG adheren…
View article: Perspectives of Primary Care Clinicians on the Diagnosis and Treatment of Pediatric Hypertension
Perspectives of Primary Care Clinicians on the Diagnosis and Treatment of Pediatric Hypertension Open
The purpose of this study was to contextualize the challenges of diagnosing and managing pediatric hypertension (pHTN) in federally qualified health centers. We conducted a survey among primary care clinicians (N = 72) who treat children (…
View article: Blood Pressure Classification Status in Children With CKD Following Adoption of the 2017 American Academy of Pediatrics Guideline
Blood Pressure Classification Status in Children With CKD Following Adoption of the 2017 American Academy of Pediatrics Guideline Open
View article: Correlates of Adherence to the 2017 Clinical Practice Guidelines for Pediatric Hypertension in Safety-Net Clinics: A Two-Year Cross-Sectional Study
Correlates of Adherence to the 2017 Clinical Practice Guidelines for Pediatric Hypertension in Safety-Net Clinics: A Two-Year Cross-Sectional Study Open
Importance The 2017 Clinical Practice Guideline (CPG) has categorized a greater proportion of children with elevated blood pressure (BP) or pHTN, and yet several barriers to CPG adherence have been noted. Objective To assess adherence to t…
View article: PHYOX2: a pivotal randomized study of nedosiran in primary hyperoxaluria type 1 or 2
PHYOX2: a pivotal randomized study of nedosiran in primary hyperoxaluria type 1 or 2 Open
Nedosiran is an investigational RNA interference agent designed to inhibit expression of hepatic lactate dehydrogenase, the enzyme thought responsible for the terminal step of oxalate synthesis. Oxalate overproduction is the hallmark of al…
View article: A stakeholder-driven method for selecting implementation strategies: a case example of pediatric hypertension clinical practice guideline implementation
A stakeholder-driven method for selecting implementation strategies: a case example of pediatric hypertension clinical practice guideline implementation Open
View article: Clinical and economic impact of primary hyperoxaluria: a retrospective claims analysis
Clinical and economic impact of primary hyperoxaluria: a retrospective claims analysis Open
BACKGROUND: Primary hyperoxaluria (PH) is a family of rare, life-threatening genetic liver disorders characterized by elevated production and excretion of oxalate. To date, the clinical and economic burden associated with PH has not…
View article: Additional file 1 of A stakeholder-driven method for selecting implementation strategies: a case example of pediatric hypertension clinical practice guideline implementation
Additional file 1 of A stakeholder-driven method for selecting implementation strategies: a case example of pediatric hypertension clinical practice guideline implementation Open
Additional file 1. Determinants—Strategies Matrix.
View article: Clinical Outcomes of Patients with C3G or IC-MPGN Treated with the Factor D Inhibitor Danicopan: Final Results from Two Phase 2 Studies
Clinical Outcomes of Patients with C3G or IC-MPGN Treated with the Factor D Inhibitor Danicopan: Final Results from Two Phase 2 Studies Open
Introduction: C3 glomerulopathy (C3G) is an ultrarare, chronic and progressive nephropathy mediated by dysregulation of the alternative pathway of complement (AP), with poor prognosis and limited treatment options. Targeted inhibition of p…
View article: Baseline Clinical Characteristics and Complement Biomarkers of Patients with C3 Glomerulopathy Enrolled in Two Phase 2 Studies Investigating the Factor D Inhibitor Danicopan
Baseline Clinical Characteristics and Complement Biomarkers of Patients with C3 Glomerulopathy Enrolled in Two Phase 2 Studies Investigating the Factor D Inhibitor Danicopan Open
Introduction: C3 glomerulopathy (C3G) is a rare, progressive kidney disease resulting from dysregulation of the alternative pathway (AP) of complement. Biomarkers at baseline were investigated in patients with C3G who participated in two p…
View article: Self-reported Race, Serum Creatinine, Cystatin C, and GFR in Children and Young Adults With Pediatric Kidney Diseases: A Report From the Chronic Kidney Disease in Children (CKiD) Study
Self-reported Race, Serum Creatinine, Cystatin C, and GFR in Children and Young Adults With Pediatric Kidney Diseases: A Report From the Chronic Kidney Disease in Children (CKiD) Study Open
View article: Cysteamine bitartrate delayed‐release capsules control leukocyte cystine levels and promote statural growth and kidney health in an open‐label study of treatment‐naïve patients <6 years of age with nephropathic cystinosis
Cysteamine bitartrate delayed‐release capsules control leukocyte cystine levels and promote statural growth and kidney health in an open‐label study of treatment‐naïve patients <6 years of age with nephropathic cystinosis Open
Nephropathic cystinosis is a rare autosomal recessive lysosomal storage disease that is characterized by accumulation of cysteine and formation of crystals within cells of different organs and tissues causing systemic manifestations in chi…
View article: Safety, pharmacodynamics, and exposure-response modeling results from a first-in-human phase 1 study of nedosiran (PHYOX1) in primary hyperoxaluria
Safety, pharmacodynamics, and exposure-response modeling results from a first-in-human phase 1 study of nedosiran (PHYOX1) in primary hyperoxaluria Open
View article: Hepatic Lactate Dehydrogenase A: An RNA Interference Target for the Treatment of All Known Types of Primary Hyperoxaluria
Hepatic Lactate Dehydrogenase A: An RNA Interference Target for the Treatment of All Known Types of Primary Hyperoxaluria Open
Phase I clinical data on nedosiran and published nonclinical data together provide substantial evidence that LDHA inhibition is a safe therapeutic mechanism for the treatment of all known types of PH.
View article: Under‐recognition of pediatric hypertension diagnosis: Examination of 1 year of visits to community health centers
Under‐recognition of pediatric hypertension diagnosis: Examination of 1 year of visits to community health centers Open
Pediatric hypertension is associated with significant target organ damage in children and cardiovascular morbidity in adulthood. Appropriate diagnosis and management per guideline recommendations are inconsistent. In this study, we determi…
View article: Hypocitraturia Is an Untoward Side Effect of Synthetic Human Parathyroid Hormone (hPTH) 1–34 Therapy in Hypoparathyroidism That May Increase Renal Morbidity
Hypocitraturia Is an Untoward Side Effect of Synthetic Human Parathyroid Hormone (hPTH) 1–34 Therapy in Hypoparathyroidism That May Increase Renal Morbidity Open
The authors have informed the Editors that after publication they found errors in the analysis and presentation of some clinical laboratory data and requested that a revision to one statement be published as an Erratum. The clinical labora…
View article: Optimizing the implementation of a population panel management intervention in safety-net clinics for pediatric hypertension (The OpTIMISe–Pediatric Hypertension Study)
Optimizing the implementation of a population panel management intervention in safety-net clinics for pediatric hypertension (The OpTIMISe–Pediatric Hypertension Study) Open
Background Though clinical practice guidelines are available, the diagnosis of pediatric hypertension (HTN) is often missed. Management may not follow guidelines due to the measurement challenges in children, complexity of interpreting you…
View article: Evaluation and Medical Management of Patients with Cystine Nephrolithiasis: A Consensus Statement
Evaluation and Medical Management of Patients with Cystine Nephrolithiasis: A Consensus Statement Open
Purpose: Cystinuria is a genetic disorder with both autosomal recessive and incompletely dominant inheritance. The disorder disrupts cystine and other dibasic amino acid transport in proximal tubules of the kidney, resulting …
View article: Assessing success in transitioning of young adults from pediatric to adult kidney practice
Assessing success in transitioning of young adults from pediatric to adult kidney practice Open
Background Transfer from a pediatric to an adult medical setting is associated with many barriers. Additionally, there are little data on patients’ assessment of the transition process itself. 3 years ago at Lurie Children’s Hospital of Ch…
View article: Prevalence and Risk Factors Associated with Renal Dysfunction in Patients withSingle Ventricle Congenital Heart Disease after Fontan Palliation
Prevalence and Risk Factors Associated with Renal Dysfunction in Patients withSingle Ventricle Congenital Heart Disease after Fontan Palliation Open
Objectives: The Fontan operation has increased survival in patients with single-ventricle congenital heart defects. However, Fontan survivors are at risk of other organ dysfunctions, such as renal dysfunction (RD). The obje... | Find, read…
View article: A Nephrology Pediatric to Adult Transition Clinic: A Pilot Program
A Nephrology Pediatric to Adult Transition Clinic: A Pilot Program Open
View article: Oh cystinosin: let me count the ways!
Oh cystinosin: let me count the ways! Open
View article: Table of Contents
Table of Contents Open
View article: Serum albumin and hospitalization among pediatric patients with end-stage renal disease who started dialysis therapy
Serum albumin and hospitalization among pediatric patients with end-stage renal disease who started dialysis therapy Open