Explanipedia

Piccolino is required for ribbon architecture at cochlear inner hair cell synapses and for hearing Open

Susann Michanski, Rohan Kapoor, Anna M. Steyer, Wiebke Möbius, Iris Früholz , et al. · 2023

Microglia actively remove NR1 autoantibody‐bound NMDA receptors and associated post‐synaptic proteins in neuron microglia co‐cultures Open

Kazi Atikur Rahman, Marta Orlando, Ayub Boulos, Ewa Andrzejak, Dietmar Schmitz , et al. · 2023

Autoantibodies against the NR1 subunit of NMDA receptors (NMDARs) have been shown to promote crosslinking and internalization of bound receptors in NMDAR encephalitis (NMDARE). This internalization‐mediated loss of NMDARs is thought to be …

Synaptic logistics: The presynaptic scaffold protein Piccolo a nodal point tuning synaptic vesicle recycling, maintenance and integrity Open

Craig C. Garner, Frauke Ackermann · 2023

© This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/. Deposited by shareyourpaper.org and openaccessbutton.org. We've taken reasonable steps to ensure this content…

Piccolino regulates the architecture of the ribbon at cochlear inner hair cell synapses Open

Susann Michanski, Rohan Kapoor, Anna M. Steyer, Wiebke Möbius, Iris Früholz , et al. · 2022

Cochlear inner hair cells (IHCs) form specialized ribbon synapses with spiral ganglion neurons that tireless-ly transmit sound information at high rates over long time periods with extreme temporal precision. This functional specialization…

Differential Modes of Action of α1- and α1γ2-Autoantibodies Derived from Patients with GABAAR Encephalitis Open

Adriana van Casteren, Frauke Ackermann, Kazi Atikur Rahman, Ewa Andrzejak, Christian Rosenmund , et al. · 2022

Autoantibodies against central nervous system proteins are increasingly being recognized in association with neurologic disorders. Although a growing number of neural autoantibodies have been identified, a causal link between specific auto…

Organization of Presynaptic Autophagy-Related Processes Open

Eckart D. Gundelfinger, Anna Karpova, Rainer Pielot, Craig C. Garner, Michael R. Kreutz · 2022

Brain synapses pose special challenges on the quality control of their protein machineries as they are far away from the neuronal soma, display a high potential for plastic adaptation and have a high energy demand to fulfill their physiolo…

Encephalitis patient-derived monoclonal GABAA receptor antibodies cause epileptic seizures. Open

Jakob Kreye, Sukhvir Wright, Adriana van Casteren, Laura Stöffler, Marie-Luise Machule , et al. · 2021

Autoantibodies targeting the GABAA receptor (GABAAR) hallmark an autoimmune encephalitis presenting with frequent seizures and psychomotor abnormalities. Their pathogenic role is still not well-defined, given the common overlap with furthe…

In vitro zinc supplementation alters synaptic deficits caused by autism spectrum disorder-associated Shank2 point mutations in hippocampal neurons Open

Yukti Vyas, Yewon Jung, Kevin Lee, Craig C. Garner, Johanna M. Montgomery · 2021

Encephalitis patient derived monoclonal GABAAreceptor antibodies cause catatonia and epileptic seizures Open

Jakob Kreye, Sukhvir Wright, Adriana van Casteren, Marie-Luise Machule, S. Momsen Reincke , et al. · 2021

Autoantibodies targeting the GABA A receptor (GABA A R) hallmark an autoimmune encephalitis presenting with frequent seizures and psychomotor abnormalities. Their pathogenic role is still not well-defined, given the common overlap with fur…

BSN (bassoon) and PRKN/parkin in concert control presynaptic vesicle autophagy Open

Carolina Montenegro‐Venegas, Anil Annamneedi, Sheila Hoffmann-Conaway, Eckart D. Gundelfinger, Craig C. Garner · 2020

Maintaining the integrity and function of the presynaptic neurotransmitter release apparatus is a demanding process for a post-mitotic neuron; the mechanisms behind it are still unclear. BSN (bassoon), an active zone scaffolding protein, h…

Translating academic careers into industry healthcare professions Open

Sinje Gehr, Craig C. Garner, Karin N. Kleinhans · 2020

Parkin contributes to synaptic vesicle autophagy in Bassoon-deficient mice Open

Sheila Hoffmann-Conaway, Marisa M. Brockmann, Katharina Schneider, Anil Annamneedi, Kazi Atikur Rahman , et al. · 2020

Mechanisms regulating the turnover of synaptic vesicle (SV) proteins are not well understood. They are thought to require poly-ubiquitination and degradation through proteasome, endo-lysosomal or autophagy-related pathways. Bassoon was sho…

Author response: Parkin contributes to synaptic vesicle autophagy in Bassoon-deficient mice Open

Sheila Hoffmann-Conaway, Marisa M. Brockmann, Katharina Schneider, Anil Annamneedi, Kazi Atikur Rahman , et al. · 2020

Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Mechanisms regulating the turnover of syna…

Loss of Piccolo Function in Rats Induces Cerebellar Network Dysfunction and Pontocerebellar Hypoplasia Type 3-like Phenotypes Open

Joanne Falck, Christine Bruns, Sheila Hoffmann-Conaway, Isabelle Straub, Erik J. Plautz , et al. · 2020

Piccolo, a presynaptic active zone protein, is best known for its role in the regulated assembly and function of vertebrate synapses. Genetic studies suggest a further link to several psychiatric disorders as well as Pontocerebellar Hypopl…

Serine–Arginine Protein Kinase SRPK2 Modulates the Assembly of the Active Zone Scaffolding Protein CAST1/ERC2 Open

Duxan Arancibia, Matías Lira, Yocelin Cruz, Daniela P. Barrera, Carolina Montenegro‐Venegas , et al. · 2019

Neurons release neurotransmitters at a specialized region of the presynaptic membrane, the active zone (AZ), where a complex meshwork of proteins organizes the release apparatus. The formation of this proteinaceous cytomatrix at the AZ (CA…

Loss of Piccolo function in rats induces Pontocerebellar Hypoplasia type 3-like phenotypes Open

Joanne Falck, Christine Bruns, Sheila Hoffmann, Isabelle Straub, Erik J. Plautz , et al. · 2019

Piccolo, a presynaptic active zone protein, is best known for its role in the regulated assembly and function of vertebrate synapses. Genetic studies suggest a further link to several psychiatric disorders as well as Pontocerebellar Hypopl…

Critical role for Piccolo in synaptic vesicle retrieval Open

Frauke Ackermann, Kay Oliver Schink, Christine Bruns, Zsuzsanna Izsvák, F. Kent Hamra , et al. · 2019

Loss of function of the active zone protein Piccolo has recently been linked to a disease, Pontocerebellar Hypoplasia type 3, which causes brain atrophy. Here, we address how Piccolo inactivation in rat neurons adversely affects synaptic f…

Author response: Critical role for Piccolo in synaptic vesicle retrieval Open

Frauke Ackermann, Kay Oliver Schink, Christine Bruns, Zsuzsanna Izsvák, F. Kent Hamra , et al. · 2019

N‐methyl‐D‐aspartate receptor dysfunction by unmutated human antibodies against the NR1 subunit Open

Nina K. Wenke, Jakob Kreye, Ewa Andrzejak, Adriana van Casteren, Jonas Leubner , et al. · 2019

Anti–N‐methyl‐D‐aspartate receptor (NMDAR) encephalitis is the most common autoimmune encephalitis related to autoantibody‐mediated synaptic dysfunction. Cerebrospinal fluid–derived human monoclonal NR1 autoantibodies showed low numbers of…

A Multiple Piccolino-RIBEYE Interaction Supports Plate-Shaped Synaptic Ribbons in Retinal Neurons Open

Tanja M. Müller, Kaspar Gierke, Anneka Joachimsthaler, Heinrich Sticht, Zsuzsanna Izsvák , et al. · 2019

Active zones at chemical synapses are highly specialized sites for the regulated release of neurotransmitters. Despite a high degree of active zone protein conservation in vertebrates, every type of chemical synapse expresses a given set o…

Light-Activated ROS Production Induces Synaptic Autophagy Open

Sheila Hoffmann, Marta Orlando, Ewa Andrzejak, Christine Bruns, Thorsten Trimbuch , et al. · 2019

The regulated turnover of synaptic vesicle (SV) proteins is thought to involve the ubiquitin-dependent tagging and degradation through endo-lysosomal and autophagy pathways. Yet, it remains unclear which of these pathways are used, when th…

Cognitive impairment and autistic-like behaviour in SAPAP4-deficient mice Open

Claudia Schob, Fabio Morellini, Ora Ohana, Lidia Bakota, Mariya V. Hrynchak , et al. · 2019

Decision letter: RIM-BP2 primes synaptic vesicles via recruitment of Munc13-1 at hippocampal mossy fiber synapses Open

Craig C. Garner · 2018

Shank and Zinc Mediate an AMPA Receptor Subunit Switch in Developing Neurons Open

Huong Ha, Sergio Leal‐Ortiz, Kriti Lalwani, Shigeki Kiyonaka, Itaru Hamachi , et al. · 2018

During development, pyramidal neurons undergo dynamic regulation of AMPA receptor (AMPAR) subunit composition and density to help drive synaptic plasticity and maturation. These normal developmental changes in AMPARs are particularly vulne…

Dietary Zinc Supplementation Prevents Autism Related Behaviors and Striatal Synaptic Dysfunction in Shank3 Exon 13–16 Mutant Mice Open

Chantelle Fourie, Yukti Vyas, Kevin Lee, Yewon Jung, Craig C. Garner , et al. · 2018

The SHANK family of synaptic proteins (SHANK1-3) are master regulators of the organizational structure of excitatory synapses in the brain. Mutations in SHANK1-3 are prevalent in patients with autism spectrum disorders (ASD), and lo…

Light induced synaptic vesicle autophagy Open

Sheila Hoffmann, Marta Orlando, Ewa Andrzejak, Thorsten Trimbuch, Christian Rosenmund , et al. · 2018

The regulated turnover of synaptic vesicle (SV) proteins is thought to involve the ubiquitin dependent tagging and degradation through endo-lysosomal and autophagy pathways. Yet, it remains unclear which of these pathways are used, when th…

Mutant screen for reproduction unveils depression-associated Piccolo’s control over reproductive behavior Open

Gerardo A. Medrano, Manvendra Singh, Erik J. Plautz, Levi B. Good, Karen Chapman , et al. · 2018

Successful sexual reproduction involves complex, genetically encoded interplay between animal physiology and behavior. The rat provides a highly fecund mammalian model for studying how the brain impacts reproduction. Here, we report a forw…

Lu TH y: a double‐readout bioluminescence‐based two‐hybrid technology for quantitative mapping of protein–protein interactions in mammalian cells Open

Philipp Trepte, Sabrina Kruse, Simona Kostova, Sheila Hoffmann, Alexander Buntru , et al. · 2018

Information on protein-protein interactions (PPIs) is of critical importance for studying complex biological systems and developing therapeutic strategies. Here, we present a double-readout bioluminescence-based two-hybrid technology, term…

Critical role for Piccolo in Synaptic Vesicle Retrieval Open

Frauke Ackermann, Kay Oliver Schink, Christine Bruns, Zsuzsanna Izsvák, F. Kent Hamra , et al. · 2018

Loss of function of the presynaptic active zone protein Piccolo has recently been linked to a devastating disease causing brain atrophy. Here, we address how Piccolo inactivation adversely affects synaptic function and thus may contributes…

Bassoon Controls Presynaptic Autophagy through Atg5 Open

Nathan D. Okerlund, Katharina Schneider, Sergio Leal‐Ortiz, Carolina Montenegro‐Venegas, Sally A. Kim , et al. · 2018

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