Explanipedia

An in vitro Perfused Macroencapsulation Device to Study Hemocompatibility and Survival of Islet-Like Cell Clusters Open

Stephanie A. Fernandez, Lisa Danielczak, Gabrielle Gauvin-Rossignol, Craig Hasilo, André Bégin‐Drolet , et al. · 2021

Transplantation of hydrogel-encapsulated pancreatic islets is a promising long-term treatment for type 1 diabetes that restores blood glucose regulation while providing graft immunoprotection. Most human-scale islet encapsulation devices t…

Overcoming barriers to facilitate the regulation of multi-centre regenerative medicine clinical trials Open

Erika Kleiderman, Audrey Boily, Craig Hasilo, Bartha Maria Knoppers · 2018

Immune Response to Extracellular Vesicles From Human Islets of Langerhans in Patients With Type 1 Diabetes Open

Alissa K. Rutman, Sarita Negi, Marco Gasparrini, Craig Hasilo, Jean Tchervenkov , et al. · 2018

The autoimmune response that characterizes type 1 diabetes (T1D) has no clear cause. Extracellular vesicles (EVs) play an important role in triggering the immune response in other contexts. Here, we propose a model by which EVs isolated fr…

Presence of diabetes autoantigens in extracellular vesicles derived from human islets Open

Craig Hasilo, Sarita Negi, Isabelle Allaeys, Nathalie Cloutier, Alissa K. Rutman , et al. · 2017

Beta-cell (β-cell) injury is the hallmark of autoimmune diabetes. However, the mechanisms by which autoreactive responses are generated in susceptible individuals are not well understood. Extracellular vesicles (EV) are produced by mammali…

Microfluidic platform for assessing pancreatic islet functionality through dielectric spectroscopy Open

Khalil Heileman, Jamal Daoud, Craig Hasilo, Marco Gasparrini, Steven Paraskevas , et al. · 2015

Human pancreatic islets are seldom assessed for dynamic responses to external stimuli. Thus, the elucidation of human islet functionality would provide insights into the progression of diabetes mellitus, evaluation of preparations for clin…

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