Colette Smith
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View article: Incorporating Stroke Severity Dynamics to Improve Prognostic Modelling in Ischaemic Stroke Patients: Evidence from Serial NIHSS Assessments in Bergen NORSTROKE Study
Incorporating Stroke Severity Dynamics to Improve Prognostic Modelling in Ischaemic Stroke Patients: Evidence from Serial NIHSS Assessments in Bergen NORSTROKE Study Open
Background Stroke severity evolves rapidly in the acute phase, and yet severity is commonly measured only on admission and treated as a static, single-timepoint measure in stroke research. This study explores routinely collected, repeated …
View article: Does time-incorporated admission severity improve stroke prognostication?
Does time-incorporated admission severity improve stroke prognostication? Open
Introduction The dynamic relationship between time since symptom onset and severity on admission is poorly incorporated in stroke prognostic models. We sought to develop a novel approach and compare it with alternatives. Methods We develop…
View article: Post-stroke facial palsy: Prevalence, recovery patterns within the first 7 days, risk factors, and effect of hyperacute treatments
Post-stroke facial palsy: Prevalence, recovery patterns within the first 7 days, risk factors, and effect of hyperacute treatments Open
Objective This study estimated the prevalence of facial palsy after stroke and identified risk factors; examined recovery patterns; and evaluated the effect of hyperacute treatments on its recovery. Design and setting This was a secondary …
View article: “SPHERE” multi-component novel psychosocial intervention for people with HIV: study protocol for a randomised controlled trial
“SPHERE” multi-component novel psychosocial intervention for people with HIV: study protocol for a randomised controlled trial Open
View article: Men matter: a cross-sectional exploration of the forgotten fathers of children born to adolescent mothers in South Africa
Men matter: a cross-sectional exploration of the forgotten fathers of children born to adolescent mothers in South Africa Open
Background Fathers are intricately bound to the experience of adolescent mothers and their children. Yet, fathers of children born to adolescent mothers, particularly within the context of HIV, remain neglected in the literature. These exp…
View article: Impact of <scp>COVID</scp>‐19 and factors associated with long <scp>COVID</scp> and <scp>COVID</scp>‐19 vaccine uptake in people with <scp>HIV</scp> in the United Kingdom: Results from Positive Voices 2022
Impact of <span>COVID</span>‐19 and factors associated with long <span>COVID</span> and <span>COVID</span>‐19 vaccine uptake in people with <span>HIV</span> in the United Kingdom: Results from Positive Voices 2022 Open
Objectives We assessed the impact of COVID‐19, and the prevalence and factors associated with a history of COVID‐19 infection, long COVID and incomplete COVID‐19 vaccine uptake among people with HIV. Methods Positive Voices 2022 is a quest…
View article: Evidence from high‐income countries on the effectiveness of psychosocial interventions to improve mental health, wellbeing and quality of life for adults living with HIV: a systematic review and meta‐analysis
Evidence from high‐income countries on the effectiveness of psychosocial interventions to improve mental health, wellbeing and quality of life for adults living with HIV: a systematic review and meta‐analysis Open
Introduction There is a need to synthesize recent evidence on the effectiveness of psychosocial interventions to improve mental health, quality of life and wellbeing in adults living with HIV in high‐income countries. A systematic review a…
View article: Severe acute respiratory syndrome coronavirus-2 antibody prevalence in adults with HIV
Severe acute respiratory syndrome coronavirus-2 antibody prevalence in adults with HIV Open
Objectives: To measure severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) antibody seroprevalence within a cohort of adults with HIV and correlate demographics with response rates to SARS CoV-2 vaccination. Design: Initial vaccin…
View article: Correction: Methodology for the Positive Voices 2022 Survey of People With HIV Accessing Care in England, Wales, and Scotland: Cross-Sectional Questionnaire Study
Correction: Methodology for the Positive Voices 2022 Survey of People With HIV Accessing Care in England, Wales, and Scotland: Cross-Sectional Questionnaire Study Open
[This corrects the article DOI: 10.2196/58531.].
View article: 20847. IMPACTO DE UN PROTOCOLO DE MANEJO MULTIDISCIPLINAR EN PACIENTES CON OCLUSIÓN DE LA ARTERIA CENTRAL DE LA RETINA SOBRE LA TASA DE RECURRENCIA VASCULAR
20847. IMPACTO DE UN PROTOCOLO DE MANEJO MULTIDISCIPLINAR EN PACIENTES CON OCLUSIÓN DE LA ARTERIA CENTRAL DE LA RETINA SOBRE LA TASA DE RECURRENCIA VASCULAR Open
View article: Methodology for the Positive Voices 2022 Survey of People With HIV Accessing Care in England, Wales, and Scotland: Cross-Sectional Questionnaire Study
Methodology for the Positive Voices 2022 Survey of People With HIV Accessing Care in England, Wales, and Scotland: Cross-Sectional Questionnaire Study Open
Background Due to advances in treatment, HIV is now a chronic condition with near-normal life expectancy. However, people with HIV continue to have a higher burden of mental and physical health conditions and are impacted by wider socioeco…
View article: Prevalence and predictors of long-term progression of chronic kidney disease in people with HIV in Ghana from 2003–2018
Prevalence and predictors of long-term progression of chronic kidney disease in people with HIV in Ghana from 2003–2018 Open
Background HIV is associated with an increased risk of progression to chronic kidney disease (CKD), and this risk is higher in people of West African descent than many other ethnicities. Our study assessed the rates of eGFR change and pred…
View article: Measures of Longitudinal Immune Dysfunction and Risk of AIDS and Non-AIDS Defining Malignancies in Antiretroviral-Treated People With Human Immunodeficiency Virus
Measures of Longitudinal Immune Dysfunction and Risk of AIDS and Non-AIDS Defining Malignancies in Antiretroviral-Treated People With Human Immunodeficiency Virus Open
Background Human immunodeficiency virus (HIV) infection leads to chronic immune activation/inflammation that can persist in virally suppressed persons on fully active antiretroviral therapy (ART) and increase risk of malignancies. The prog…
View article: Association of age at antiretroviral therapy initiation with CD4+ : CD8+ ratio recovery among virally suppressed people with HIV
Association of age at antiretroviral therapy initiation with CD4+ : CD8+ ratio recovery among virally suppressed people with HIV Open
Objective: To investigate the association of age at antiretroviral therapy (ART) initiation with CD4 + : CD8 + T-cell ratio in virally suppressed people with HIV on long-term ART, and to characterize potential CD4 + : CD8 + ratio recovery …
View article: All-cause hospitalisation among people living with HIV according to gender, mode of HIV acquisition, ethnicity, and geographical origin in Europe and North America: findings from the ART-CC cohort collaboration
All-cause hospitalisation among people living with HIV according to gender, mode of HIV acquisition, ethnicity, and geographical origin in Europe and North America: findings from the ART-CC cohort collaboration Open
View article: The epidemiology of adolescents living with perinatally acquired HIV: A cross-region global cohort analysis
The epidemiology of adolescents living with perinatally acquired HIV: A cross-region global cohort analysis Open
Background: Globally, the population of adolescents living with perinatally acquired HIV (APHs) continues to expand. In this study, we pooled data from observational pediatric HIV cohorts and cohort networks, allowing comparisons of adoles…
View article: Performance of SARS COV-2 IgG Anti-N as an Independent Marker of Exposure to SARS COV-2 in an Unvaccinated West African Population
Performance of SARS COV-2 IgG Anti-N as an Independent Marker of Exposure to SARS COV-2 in an Unvaccinated West African Population Open
Determination of previous SARS-COV-2 infection is hampered by the absence of a standardized test. The marker used to assess previous exposure is IgG antibody to the nucleocapsid (IgG anti-N), although it is known to wane quickly from perip…
View article: Cross-sectional study evaluating the impact of SARS-CoV-2 variants on Long COVID outcomes in UK hospital survivors
Cross-sectional study evaluating the impact of SARS-CoV-2 variants on Long COVID outcomes in UK hospital survivors Open
Objectives COVID-19 studies report on hospital admission outcomes across SARS-CoV-2 waves of infection but knowledge of the impact of SARS-CoV-2 variants on the development of Long COVID in hospital survivors is limited. We sought to inves…
View article: Trends in Cancer Incidence in Different Antiretroviral Treatment-Eras amongst People with HIV
Trends in Cancer Incidence in Different Antiretroviral Treatment-Eras amongst People with HIV Open
Despite cancer being a leading comorbidity amongst individuals with HIV, there are limited data assessing cancer trends across different antiretroviral therapy (ART)-eras. We calculated age-standardised cancer incidence rates (IRs) from 20…
View article: Investigation into the psychological impact of the COVID-19 pandemic for people living with HIV
Investigation into the psychological impact of the COVID-19 pandemic for people living with HIV Open
Background People living with HIV (PLWH) report high levels of anxiety. This study assessed the prevalence of COVID-19-related anxiety in PLWH. Methods Participants were recruited from two UK HIV clinics (01/03/2020 - 30/05/2022) and asked…
View article: Plasma Human Immunodeficiency Virus 1 RNA and CD4+ T-Cell Counts Are Determinants of Virological Nonsuppression Outcomes With Initial Integrase Inhibitor-Based Regimens: A Prospective RESPOND Cohort Study
Plasma Human Immunodeficiency Virus 1 RNA and CD4+ T-Cell Counts Are Determinants of Virological Nonsuppression Outcomes With Initial Integrase Inhibitor-Based Regimens: A Prospective RESPOND Cohort Study Open
Background There are conflicting data regarding baseline determinants of virological nonsuppression outcomes in persons with human immunodeficiency virus (HIV) starting antiretroviral treatment (ART). We evaluated the impact of different b…
View article: Hepatitis B virus infection in general practice across England: An analysis of the Royal College of General Practitioners Research and Surveillance Centre real-world database
Hepatitis B virus infection in general practice across England: An analysis of the Royal College of General Practitioners Research and Surveillance Centre real-world database Open
View article: Exploring the cognitive development of children born to adolescent mothers in South Africa
Exploring the cognitive development of children born to adolescent mothers in South Africa Open
This study explores the cognitive development of children born to adolescent mothers within South Africa compared to existing reference data, and explores development by child age bands to examine relative levels of development. Cross‐sect…
View article: Predictors of long-term progression to chronic kidney disease in HIV infection in Ghana from 2003-2018
Predictors of long-term progression to chronic kidney disease in HIV infection in Ghana from 2003-2018 Open
Aim HIV is associated with an increased risk of progression to chronic kidney disease (CKD), and this risk is higher in people of West African descent than many other ethnicities. Our study aimed to assess the rates of progression to CKD a…
View article: Bone Mineral Density and Vascular Calcification in Children and Young Adults With CKD 4 to 5 or on Dialysis
Bone Mineral Density and Vascular Calcification in Children and Young Adults With CKD 4 to 5 or on Dialysis Open
View article: Adolescent mothers and their children affected by HIV—An exploration of maternal mental health, and child cognitive development
Adolescent mothers and their children affected by HIV—An exploration of maternal mental health, and child cognitive development Open
Background Some children born to adolescent mothers may have developmental challenges, while others do not. Research focusing on which children of adolescent mothers are at the highest risk for cognitive delay is still required. Both mater…
View article: Falling treatment uptake in the hepatitis C care cascade is a growing threat to achieving elimination
Falling treatment uptake in the hepatitis C care cascade is a growing threat to achieving elimination Open
Most high‐income countries are not on track to achieve the World Health Organization hepatitis C elimination targets. As elimination programmes assess growing proportions of patients in community‐based pathways, rates of treatment uptake m…
View article: Risk factors for poor mental health among adolescent mothers in South Africa
Risk factors for poor mental health among adolescent mothers in South Africa Open
In South Africa, high rates of adolescent pregnancy and HIV pose prominent public health challenges with potential implications for mental wellbeing. It is important to understand risk factors for mental health difficulties among adolescen…
View article: Liver steatosis and fibrosis in people with human immunodeficiency virus in West Africa and the relationship with hepatitis B virus coinfection
Liver steatosis and fibrosis in people with human immunodeficiency virus in West Africa and the relationship with hepatitis B virus coinfection Open
There is a heavy burden of liver disease in West Africa. While the role of hepatitis B virus (HBV) infection is well recognized, less is known about the contributing role of liver steatosis and how the two interact in the context of human …
View article: Coproduced resources to support parents caring for children with gastrostomies
Coproduced resources to support parents caring for children with gastrostomies Open
Objective To describe and disseminate a package of support for parents who care for children with gastrostomies, consisting of a library of videos and resources to support families from referral for gastrostomy surgery, to long-term suppor…