Craig S. Robb
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View article: Sulfated mannan helps diatoms domesticate their microbiome
Sulfated mannan helps diatoms domesticate their microbiome Open
Background Diatoms are a keystone phylum in Earth’s ecosystems, responsible for substantial oxygen production and carbohydrate fixation that fuel global food webs. They host diverse microbiomes, yet how diatoms preferentially recruit bacte…
View article: Structural and kinetic analysis of the monofunctional Staphylococcus aureus PBP1
Structural and kinetic analysis of the monofunctional Staphylococcus aureus PBP1 Open
Staphylococcus aureus, an ESKAPE pathogen, is a major clinical concern due to its pathogenicity and manifold antimicrobial resistance mechanisms. The commonly used β-lactam antibiotics target bacterial penicillin-binding proteins (PBPs) an…
View article: 1395 Targeting intracellular tumor antigens to Figureht cancer: discovery and development of functional and specific T-cell engagers against a MAGE-A4 pMHC
1395 Targeting intracellular tumor antigens to Figureht cancer: discovery and development of functional and specific T-cell engagers against a MAGE-A4 pMHC Open
Background Bispecific T-cell engagers (TCEs) activate the immune system to Figureht cancer. TCEs that target peptides displayed on major histocompatibility complexes (pMHC) have shown promise for unlocking previously inaccessible intracell…
View article: Identification of an Optimized Receptor-Binding Domain Subunit Vaccine against SARS-CoV-2
Identification of an Optimized Receptor-Binding Domain Subunit Vaccine against SARS-CoV-2 Open
Current vaccine efforts to combat SARS-CoV-2 are focused on the whole spike protein administered as mRNA, viral vector, or protein subunit. However, the SARS-CoV-2 receptor-binding domain (RBD) is the immunodominant portion of the spike pr…
View article: Marine bacteroidetes use a conserved enzymatic cascade to digest diatom β-mannan
Marine bacteroidetes use a conserved enzymatic cascade to digest diatom β-mannan Open
The polysaccharide β-mannan, which is common in terrestrial plants but unknown in microalgae, was recently detected during diatom blooms. We identified a β-mannan polysaccharide utilization locus (PUL) in the genome of the marine flavobact…
View article: Characterization of the Pilotin-Secretin Complex from the Salmonella enterica Type III Secretion System Using Hybrid Structural Methods
Characterization of the Pilotin-Secretin Complex from the Salmonella enterica Type III Secretion System Using Hybrid Structural Methods Open
View article: The structure of <i>Pf</i>GH50B, an agarase from the marine bacterium <i>Pseudoalteromonas fuliginea</i> PS47
The structure of <i>Pf</i>GH50B, an agarase from the marine bacterium <i>Pseudoalteromonas fuliginea</i> PS47 Open
The recently identified marine bacterium Pseudoalteromonas fuliginea sp. PS47 possesses a polysaccharide-utilization locus dedicated to agarose degradation. In particular, it contains a gene (locus tag EU509_06755) encoding a β-agarase tha…
View article: Structure of the Peptidoglycan Synthase Activator LpoP in Pseudomonas aeruginosa
Structure of the Peptidoglycan Synthase Activator LpoP in Pseudomonas aeruginosa Open
View article: Data for EMSL Project 51300 from May 2020
Data for EMSL Project 51300 from May 2020 Open
View article: Data for EMSL Project 51300 from May 2020
Data for EMSL Project 51300 from May 2020 Open
View article: Data for EMSL Project 51300 from May 2020
Data for EMSL Project 51300 from May 2020 Open
View article: Data for EMSL Project 51300 from May 2020
Data for EMSL Project 51300 from May 2020 Open
View article: Data for EMSL Project 51300 from May 2020
Data for EMSL Project 51300 from May 2020 Open
View article: Data for EMSL Project 51300 from May 2020
Data for EMSL Project 51300 from May 2020 Open
View article: Data for EMSL Project 51300 from May 2020
Data for EMSL Project 51300 from May 2020 Open
View article: A marine bacterial enzymatic cascade degrades the algal polysaccharide ulvan
A marine bacterial enzymatic cascade degrades the algal polysaccharide ulvan Open
View article: Specificity and mechanism of carbohydrate demethylation by cytochrome P450 monooxygenases
Specificity and mechanism of carbohydrate demethylation by cytochrome P450 monooxygenases Open
Degradation of carbohydrates by bacteria represents a key step in energy metabolism that can be inhibited by methylated sugars. Removal of methyl groups, which is critical for further processing, poses a biocatalytic challenge because enzy…
View article: Molecular recognition of the beta‐glucans laminarin and pustulan by a SusD‐like glycan‐binding protein of a marine <i>Bacteroidetes</i>
Molecular recognition of the beta‐glucans laminarin and pustulan by a SusD‐like glycan‐binding protein of a marine <i>Bacteroidetes</i> Open
Marine bacteria catabolize carbohydrate polymers of algae, which synthesize these structurally diverse molecules in ocean surface waters. Although algal glycans are an abundant carbon and energy source in the ocean, the molecular details t…
View article: Alpha‐ and beta‐mannan utilization by marine <i>Bacteroidetes</i>
Alpha‐ and beta‐mannan utilization by marine <i>Bacteroidetes</i> Open
Summary Marine microscopic algae carry out about half of the global carbon dioxide fixation into organic matter. They provide organic substrates for marine microbes such as members of the Bacteroidetes that degrade algal polysaccharides us…
View article: Adaptive mechanisms that provide competitive advantages to marine bacteroidetes during microalgal blooms
Adaptive mechanisms that provide competitive advantages to marine bacteroidetes during microalgal blooms Open
Polysaccharide degradation by heterotrophic microbes is a key process within Earth’s carbon cycle. Here, we use environmental proteomics and metagenomics in combination with cultivation experiments and biochemical characterizations to inve…
View article: The Molecular Basis of Polysaccharide Sulfatase Activity and a Nomenclature for Catalytic Subsites in this Class of Enzyme
The Molecular Basis of Polysaccharide Sulfatase Activity and a Nomenclature for Catalytic Subsites in this Class of Enzyme Open
View article: Crystal structure of a marine glycoside hydrolase family 99‐related protein lacking catalytic machinery
Crystal structure of a marine glycoside hydrolase family 99‐related protein lacking catalytic machinery Open
Algal polysaccharides of diverse structures are one of the most abundant carbon resources for heterotrophic, marine bacteria with coevolved digestive enzymes. A putative sulfo‐mannan polysaccharide utilization locus, which is conserved in …
View article: The Structure of the Toxin and Type Six Secretion System Substrate Tse2 in Complex with Its Immunity Protein
The Structure of the Toxin and Type Six Secretion System Substrate Tse2 in Complex with Its Immunity Protein Open
View article: A Second β-Hexosaminidase Encoded in the Streptococcus pneumoniae Genome Provides an Expanded Biochemical Ability to Degrade Host Glycans
A Second β-Hexosaminidase Encoded in the Streptococcus pneumoniae Genome Provides an Expanded Biochemical Ability to Degrade Host Glycans Open
An important facet of the interaction between the pathogen Streptococcus pneumoniae (pneumococcus) and its human host is the ability of this bacterium to process host glycans. To achieve cleavage of the glycosidic bonds in host glycans, S.…