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View article: IRF2 degradation tunes the innate immune response
IRF2 degradation tunes the innate immune response Open
Summary The transcription factor IRF2 protects against skin inflammation in mice and humans but, paradoxically, promotes pyroptosis by inducing Gsdmd . How IRF2 activates some proinflammatory genes, but suppresses others is unclear. We sho…
View article: Issue Information
Issue Information Open
s Corporate Citizenship initiative seeks to address the environmental, social, economic, and ethical challenges faced in our business and which are important to our diverse stakeholder groups.Since launching the initiative, we have focused…
View article: Stress granules are shock absorbers that prevent excessive innate immune responses to dsRNA
Stress granules are shock absorbers that prevent excessive innate immune responses to dsRNA Open
View article: Stress granules are shock absorbers that prevent excessive innate immune responses to dsRNA
Stress granules are shock absorbers that prevent excessive innate immune responses to dsRNA Open
Summary Proper defense against microbial infection depends on the controlled activation of the immune system. This is particularly important for the RIG-I-like receptors (RLRs), which recognize viral dsRNA and initiate antiviral innate imm…
View article: Filament-like Assemblies of Intracellular Nucleic Acid Sensors: Commonalities and Differences
Filament-like Assemblies of Intracellular Nucleic Acid Sensors: Commonalities and Differences Open
View article: N6-Methyladenosine Modification Controls Circular RNA Immunity
N6-Methyladenosine Modification Controls Circular RNA Immunity Open
View article: The effect of HIV-1 Vif polymorphisms on A3G anti-viral activity in an in vivo mouse model
The effect of HIV-1 Vif polymorphisms on A3G anti-viral activity in an in vivo mouse model Open
Humans encode seven APOBEC3 proteins (A–H), with A3G, 3F and 3H as the major factors restricting HIV-1 replication. HIV-1, however, encodes Vif, which counteracts A3 proteins by chaperoning them to the proteasome where they are degraded. V…
View article: The FDA-Approved Oral Drug Nitazoxanide Amplifies Host Antiviral Responses and Inhibits Ebola Virus
The FDA-Approved Oral Drug Nitazoxanide Amplifies Host Antiviral Responses and Inhibits Ebola Virus Open
View article: Ubiquitin-Dependent and -Independent Roles of E3 Ligase RIPLET in Innate Immunity
Ubiquitin-Dependent and -Independent Roles of E3 Ligase RIPLET in Innate Immunity Open
View article: Ubiquitin-dependent and -independent roles of E3 ligase RIPLET in innate immunity
Ubiquitin-dependent and -independent roles of E3 ligase RIPLET in innate immunity Open
The conventional view posits that E3 ligases function primarily through conjugating ubiquitin (Ub) to their substrate molecules. We report here that RIPLET, an essential E3 ligase in antiviral immunity, promotes the antiviral signaling act…
View article: Antiviral Immunity and Circular RNA: No End in Sight
Antiviral Immunity and Circular RNA: No End in Sight Open
View article: The effect of HIV-1 Vif polymorphisms on A3G anti-viral activity in an in vivo mouse model
The effect of HIV-1 Vif polymorphisms on A3G anti-viral activity in an in vivo mouse model Open
Humans encode seven APOBEC3 proteins (A-H), with A3G, 3F and 3H as the major factors restricting HIV-1 replication. HIV-1, however, encodes Vif, which counteracts A3 proteins by chaperoning them to the proteasome where they are degraded. V…