Cristian Andrei Sarău
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View article: REACT-UTI: A 72-Hour Composite to Predict Early Non-Response and Length of Stay in Hospitalized Adults with Lower Urinary Tract Infection—A Prospective Observational Study
REACT-UTI: A 72-Hour Composite to Predict Early Non-Response and Length of Stay in Hospitalized Adults with Lower Urinary Tract Infection—A Prospective Observational Study Open
Background and Objectives: Early bedside tools that flag non-response in hospitalized adults with lower urinary tract infection (UTI) could align clinical care with antimicrobial stewardship. We evaluated REACT-UTI, a 72 h composite combin…
View article: A rare case of diffuse large B-cell lymphoma of the frontal sinus and rapid review of literature
A rare case of diffuse large B-cell lymphoma of the frontal sinus and rapid review of literature Open
Introduction: Primary lymphoma of the paranasal sinuses, especially involving the frontal sinus, is exceedingly rare. Extranodal non-Hodgkin lymphoma (NHL) located in the head and neck frequently poses diagnostic challenges because its non…
View article: Comparative Assessment of Lower Urinary Tract Infections in Hospitalized Adults from Western Romania: A Retrospective Cohort with Microbiological Analysis
Comparative Assessment of Lower Urinary Tract Infections in Hospitalized Adults from Western Romania: A Retrospective Cohort with Microbiological Analysis Open
Urinary tract infections (UTIs) remain a leading cause of healthcare-associated morbidity, particularly in patients with indwelling urinary catheters. This study aimed to compare catheter-associated (CAUTIs) and non-catheter-associated UTI…
View article: Cardio-Renal Syndrome: Latest Developments in Device-Based Therapy
Cardio-Renal Syndrome: Latest Developments in Device-Based Therapy Open
Background: Cardio-renal syndrome (CRS) is a complex condition involving bidirectional dysfunction of the heart and kidneys, in which the failure of one organ exacerbates failure in the other. Traditional pharmacologic treatments are often…
View article: Morphological and Immunohistochemical Aspects with Prognostic Implications and Therapeutic Targets of Primary Sinonasal Mucosal Melanoma: A Retrospective Study
Morphological and Immunohistochemical Aspects with Prognostic Implications and Therapeutic Targets of Primary Sinonasal Mucosal Melanoma: A Retrospective Study Open
Sinonasal mucosal melanoma originates from melanocytes and it is a rare malignancy in the sinonasal tract. It is an aggressive melanocytic neoplasm with a very poor prognosis. The symptoms are nonspecific and the diagnosis is delayed, usua…
View article: Otosclerosis under the magnifying glass
Otosclerosis under the magnifying glass Open
Otosclerosis is a bone condition affecting the stapes bone within the otic capsule, and its exact cause is still unknown. It is characterized by a lack of proper remodeling of newly formed vascular and woven bone, leading to the developmen…
View article: Olfactory Neuroblastoma—A Challenging Fine Line between Metastasis and Hematology
Olfactory Neuroblastoma—A Challenging Fine Line between Metastasis and Hematology Open
Developing in a limited space, rare tumors located at the nose and paranasal sinuses are sometimes difficult to diagnose due to their modest clinical presentation, which is uncorrelated with anatomopathological diversity. This limits the p…
View article: Granulomatosis with Polyangiitis (GPA)—A Multidisciplinary Approach of a Case Report
Granulomatosis with Polyangiitis (GPA)—A Multidisciplinary Approach of a Case Report Open
Granulomatosis with polyangiitis is an atypical, multisystem disease with unknown etiology that generally affects both genders equally, with a predominance in the Caucasian racial group for individuals in their fourth decade. The disease a…
View article: Development and Preliminary Characterization of Polyester-Urethane Microparticles Used in Curcumin Drug Delivery System for Oropharyngeal Cancer
Development and Preliminary Characterization of Polyester-Urethane Microparticles Used in Curcumin Drug Delivery System for Oropharyngeal Cancer Open
Background and Objectives: Curcumin (Cc) as an active substance is known for its anti-inflammatory, anticoagulant, antioxidant, and anti-carcinogenic effects, together with its role in cholesterol regulation, and its use in different gastr…
View article: Synthesis and Characterization of Bioactive Magnetic Nanoparticles from the Perspective of Hyperthermia Applications
Synthesis and Characterization of Bioactive Magnetic Nanoparticles from the Perspective of Hyperthermia Applications Open
Magnetic iron oxide nanoparticles were obtained for the first time via the green chemistry approach, starting from two aqueous extracts of wormwood (Artemisia absinthium L.), both leaf and stems. In order to obtain magnetic nanoparticles s…
View article: Chemical and Antimicrobial Characterization of Mentha piperita L. and Rosmarinus officinalis L. Essential Oils and In Vitro Potential Cytotoxic Effect in Human Colorectal Carcinoma Cells
Chemical and Antimicrobial Characterization of Mentha piperita L. and Rosmarinus officinalis L. Essential Oils and In Vitro Potential Cytotoxic Effect in Human Colorectal Carcinoma Cells Open
Colorectal cancer is one of the most frequently diagnosed forms of cancer, and the therapeutic solutions are frequently aggressive requiring improvements. Essential oils (EOs) are secondary metabolites of aromatic plants with important pha…
View article: Assessment of the In Vitro Cytotoxic Profile of Two Broad-Spectrum Antibiotics—Tetracycline and Ampicillin—On Pharyngeal Carcinoma Cells
Assessment of the In Vitro Cytotoxic Profile of Two Broad-Spectrum Antibiotics—Tetracycline and Ampicillin—On Pharyngeal Carcinoma Cells Open
Background and Objectives: In spite of the fact that antibiotics are considered to be the cornerstone of modern medicine, their use in the treatment of cancer remains controversial. In the present study, the main objective was to examine t…
View article: Laryngeal malignancies – epidemiological data and particularities of the cases diagnosed in Western Romania (October 2016–July 2020)
Laryngeal malignancies – epidemiological data and particularities of the cases diagnosed in Western Romania (October 2016–July 2020) Open
In the last decade, the incidence and mortality associated with laryngeal malignancies has experienced an unfavorable evolution in Romania, in terms of this pathology the country that has become the leader, among the European Union (EU)-27…
View article: A Combination of Two Probiotics, Lactobacillus sporogenes and Clostridium butyricum, Inhibits Colon Cancer Development: An In Vitro Study
A Combination of Two Probiotics, Lactobacillus sporogenes and Clostridium butyricum, Inhibits Colon Cancer Development: An In Vitro Study Open
Cancer remains a leading cause of death worldwide and, even though several advances have been made in terms of specific treatment, the late-stage detection and the associated side effects of the conventional drugs sustain the search for be…
View article: Nicotine Exerts Cytotoxic Effects in a Panel of Healthy Cell Lines and Strong Irritating Potential on Blood Vessels
Nicotine Exerts Cytotoxic Effects in a Panel of Healthy Cell Lines and Strong Irritating Potential on Blood Vessels Open
The use of tobacco products is a major global public health issue, as it is the leading cause of preventable death worldwide. In addition, nicotine (NIC) is a key component of electronic and conventional cigarettes. Although nicotine’s add…
View article: Fortuitous discovery of melanomas in the ENT Department – a histopathological and immunohistochemical study
Fortuitous discovery of melanomas in the ENT Department – a histopathological and immunohistochemical study Open
The melanoma, having its origin in the melanocyte cells, is one of the most aggressive forms of skin cancer in the world with one of the highest rates of brain metastasis. The incidence of cutaneous melanoma in the Mediterranean countries …
View article: Silver Nanocolloids Loaded with Betulinic Acid with Enhanced Antitumor Potential: Physicochemical Characterization and In Vitro Evaluation
Silver Nanocolloids Loaded with Betulinic Acid with Enhanced Antitumor Potential: Physicochemical Characterization and In Vitro Evaluation Open
Betulinic acid (BA), a natural compound with various health benefits including selective antitumor activity, has a limited applicability in vivo due to its poor water solubility and bioavailability. Thus, this study focused on obtaining a …
View article: Morphological Variations of Posterior Segmental Artery of the Single Renal Artery. Study on corrosion casts
Morphological Variations of Posterior Segmental Artery of the Single Renal Artery. Study on corrosion casts Open
On a total of 150 renal corrosion casts were examined the posterior branch and the artery of renal posterior segment. For the origin of the posterior branch, there have been highlighted three morphological types, namely: Type I, bifurcatio…