Cristian V. A. Munteanu
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View article: A novel cytotoxic anti-B7-H3 affibody with therapeutic potential in acute myeloid leukemia
A novel cytotoxic anti-B7-H3 affibody with therapeutic potential in acute myeloid leukemia Open
Introduction Acute Myeloid Leukemia (AML) is a group of very aggressive hematological malignancies, with dismal long-term survival rates and little therapeutic recourse presently. The transmembrane ligand B7-H3 is a known therapeutic targe…
View article: Fast-COLD PCR Protocol for Enrichment of TP53 R181H Variant Before Sanger Sequencing v1
Fast-COLD PCR Protocol for Enrichment of TP53 R181H Variant Before Sanger Sequencing v1 Open
This protocol describes the wet-lab steps for enrichment of mosaic TP53 R181H variant using Fast-COLD PCR program before Sanger sequencing.
View article: Ultra-High Dose Rate Ionizing Radiation for FLASH Radiotherapy Applications
Ultra-High Dose Rate Ionizing Radiation for FLASH Radiotherapy Applications Open
Radiation therapy (RT) is an essential component of curative cancer treatment. Technological advances in RT aim to make treatments more precise, efficient, and personalized. Recent FLASH-induced radiotherapeutic strategies employ ultra-hig…
View article: Toll Like Receptor 7/8 agonists antitumor effects on NK cells in murine melanoma model
Toll Like Receptor 7/8 agonists antitumor effects on NK cells in murine melanoma model Open
Background: Toll-like receptors (TLRs) are a subclass of molecules that regulate both innate and adaptive immune cells, and this ability makes them attractive targets for cancer immunotherapy. Synthetic TLR agonists, such as imidazoquinoli…
View article: Structure and function of the EDEM:PDI ERAD checkpoint complex
Structure and function of the EDEM:PDI ERAD checkpoint complex Open
The ERAD glycoprotein misfolding checkpoint complex de-mannosylates misfolded glycoproteins targeting them to retrotranslocation, ubiquitination, and proteasomal degradation. The complex comprises an Endoplasmic Reticulum-Degradation Enhan…
View article: Structure and function of the EDEM:PDI ERAD checkpoint complex
Structure and function of the EDEM:PDI ERAD checkpoint complex Open
The ERAD glycoprotein misfolding checkpoint complex de-mannosylates misfolded glycoproteins to enable retrotranslocation, ubiquitination, and proteasomal degradation. The complex comprises an Endoplasmic Reticulum-Degradation Enhancing α-M…
View article: Hybrid bio-nanoporous peptide loaded-polymer platforms with anticancer and antibacterial activities
Hybrid bio-nanoporous peptide loaded-polymer platforms with anticancer and antibacterial activities Open
pNIPAM- co -BA coatings featuring nanopore biointerfaces obtained vis laser methods incorporating magainin/melittin peptides impair bacterial growth and reduce cancer cell proliferation.
View article: New panel of biomarkers to discriminate between amelanotic and melanotic metastatic melanoma
New panel of biomarkers to discriminate between amelanotic and melanotic metastatic melanoma Open
Melanoma is a form of skin cancer that can rapidly invade distant organs. A distinctive feature of melanomas is their pigmentation status, as melanin is present in most skin melanomas, whilst many metastatic tumors could become amelanotic.…
View article: Defining the altered glycoproteomic space of the early secretory pathway by class I mannosidase pharmacological inhibition
Defining the altered glycoproteomic space of the early secretory pathway by class I mannosidase pharmacological inhibition Open
N-glycosylation is a key process for various biological functions like protein folding, maturation and sorting for the conventional secretory compartment, cell-cell communication and immune response. This is usually accomplished by a compl…
View article: Structural Investigation of Betulinic Acid Plasma Metabolites by Tandem Mass Spectrometry
Structural Investigation of Betulinic Acid Plasma Metabolites by Tandem Mass Spectrometry Open
Betulinic acid (BA) has been extensively studied in recent years mainly for its antiproliferative and antitumor effect in various types of cancers. Limited data are available regarding the pharmacokinetic profile of BA, particularly its me…
View article: A Study on Repositioning Nalidixic Acid via Lanthanide Complexation: Synthesis, Characterization, Cytotoxicity and DNA/Protein Binding Studies
A Study on Repositioning Nalidixic Acid via Lanthanide Complexation: Synthesis, Characterization, Cytotoxicity and DNA/Protein Binding Studies Open
“Drug repositioning” is a modern strategy used to uncover new applications for out-of-date drugs. In this context, nalidixic acid, the first member of the quinolone class with limited use today, has been selected to obtain nine new metal c…
View article: Gangliosidome of a Human Hippocampus in Temporal Lobe Epilepsy Resolved by High-Resolution Tandem Mass Spectrometry
Gangliosidome of a Human Hippocampus in Temporal Lobe Epilepsy Resolved by High-Resolution Tandem Mass Spectrometry Open
In this study, we developed a high-resolution tandem mass spectrometry (HR MS) approach to assess presumed changes in gangliosidome of a human hippocampus affected by temporal lobe epilepsy (TLE) in comparison with a normal hippocampus. Ga…
View article: MO635: Early Diabetic Kidney Disease in Type 2 Diabetes Mellitus Patients is Associated with A Particular Ganglioside Profile, Identified by High-Resolution Tandem Mass Spectrometry<b>:</b>A Pilot Study
MO635: Early Diabetic Kidney Disease in Type 2 Diabetes Mellitus Patients is Associated with A Particular Ganglioside Profile, Identified by High-Resolution Tandem Mass Spectrometry<b>:</b>A Pilot Study Open
BACKGROUND AND AIMS Metabolic biomarkers are of high importance for the identification of early renal involvement in the course of type 2 diabetes mellitus (DM). Gangliosides, which are complex cell type-specific glycosphingolipids, consis…
View article: High-Resolution Tandem Mass Spectrometry Identifies a Particular Ganglioside Pattern in Early Diabetic Kidney Disease of Type 2 Diabetes Mellitus Patients
High-Resolution Tandem Mass Spectrometry Identifies a Particular Ganglioside Pattern in Early Diabetic Kidney Disease of Type 2 Diabetes Mellitus Patients Open
Considering the valuable information provided by glycosphingolipids as molecular markers and the limited data available for their detection and characterization in patients suffering from Type 2 diabetic kidney disease (DKD), we developed …
View article: PULMONARY FINDINGS SUGGESTS COXIELLA BURNETII INFECTION TO A PATIENT WITH HEPATITIS
PULMONARY FINDINGS SUGGESTS COXIELLA BURNETII INFECTION TO A PATIENT WITH HEPATITIS Open
On 23th of July 2019 a 63y old man, was admitted for acute hepatitis with low-grade fever, myalgia, fatigue, jaundice. Farmer (grows crops, and tends to farm animals). He was known to have a non-replicative chronic B hepatitis virus infect…
View article: Trojan horse treatment based on PEG-coated extracellular vesicles to deliver doxorubicin to melanoma <i>in vitro</i> and <i>in vivo</i>
Trojan horse treatment based on PEG-coated extracellular vesicles to deliver doxorubicin to melanoma <i>in vitro</i> and <i>in vivo</i> Open
Tailoring extracellular vesicles (EVs) as targeted drug delivery systems to enhance the therapeutic efficacy showed superior advantage over liposomal therapies. Herein, we developed a novel nanotool for targeting B16.F10 murine melanoma, b…
View article: Designed Peptide Inhibitors of STEP Phosphatase–GluA2 AMPA Receptor Interaction Enhance the Cognitive Performance in Rats
Designed Peptide Inhibitors of STEP Phosphatase–GluA2 AMPA Receptor Interaction Enhance the Cognitive Performance in Rats Open
Cognitive impairment and learning ability of the brain are directly linked to synaptic plasticity as measured in changes of long-term potentiation (LTP) and long-term depression (LTD) in animal models of brain diseases. LTD reflects a sust…
View article: Y2O3 Nanoparticles and X-ray Radiation-Induced Effects in Melanoma Cells
Y2O3 Nanoparticles and X-ray Radiation-Induced Effects in Melanoma Cells Open
The innovative strategy of using nanoparticles in radiotherapy has become an exciting topic due to the possibility of simultaneously improving local efficiency of radiation in tumors and real-time monitoring of the delivered doses. Yttrium…
View article: Trojan Horse Treatment Based on Peg-Coated Extracellular Vesicles to Deliver Doxorubicin to Melanoma in Vitro and in Vivo
Trojan Horse Treatment Based on Peg-Coated Extracellular Vesicles to Deliver Doxorubicin to Melanoma in Vitro and in Vivo Open
Tailoring extracellular vesicles (EVs) as targeted drug delivery systems to enhance the therapeutic efficacy showed superior advantage over liposomal therapies. Herein, we developed a novel nanotool for targeting B16.F10 murine melanoma, b…
View article: EDEM3 Domains Cooperate to Perform Its Overall Cell Functioning
EDEM3 Domains Cooperate to Perform Its Overall Cell Functioning Open
EDEM3 recognizes and directs misfolded proteins to the ER-associated protein degradation (ERAD) process. EDEM3 was predicted to act as lectin or as a mannosidase because of its homology with the GH47 catalytic domain of the Man1B1, but the…
View article: Rare-Earth Metal Complexes of the Antibacterial Drug Oxolinic Acid: Synthesis, Characterization, DNA/Protein Binding and Cytotoxicity Studies
Rare-Earth Metal Complexes of the Antibacterial Drug Oxolinic Acid: Synthesis, Characterization, DNA/Protein Binding and Cytotoxicity Studies Open
“Drug repositioning” is a current trend which proved useful in the search for new applications for existing, failed, no longer in use or abandoned drugs, particularly when addressing issues such as bacterial or cancer cells resistance to c…
View article: EDEM1 Drives Misfolded Protein Degradation via ERAD and Exploits ER-Phagy as Back-Up Mechanism When ERAD Is Impaired
EDEM1 Drives Misfolded Protein Degradation via ERAD and Exploits ER-Phagy as Back-Up Mechanism When ERAD Is Impaired Open
Endoplasmic reticulum (ER)-associated degradation (ERAD) is the main mechanism of targeting ER proteins for degradation to maintain homeostasis, and perturbations of ERAD lead to pathological conditions. ER-degradation enhancing α-mannosid…
View article: Functionalized Graphene Oxide Thin Films for Anti-tumor Drug Delivery to Melanoma Cells
Functionalized Graphene Oxide Thin Films for Anti-tumor Drug Delivery to Melanoma Cells Open
Since Graphene discovery, their associated derivate nanomaterials, Graphene Oxide (GO) and reduced-GO were in the forefront of continuous developments in bio-nano-technology due to unique physical-chemical properties. Although GO nano-coll…
View article: Analysis of EYA3 Phosphorylation by Src Kinase Identifies Residues Involved in Cell Proliferation
Analysis of EYA3 Phosphorylation by Src Kinase Identifies Residues Involved in Cell Proliferation Open
Eyes absent (EYA) are non-thiol-based protein tyrosine phosphatases (PTPs) that also have transcriptional co-activator functions. Their PTP activity is involved in various pathologies. Recently, we demonstrated that Src tyrosine kinase pho…
View article: New Carbocyclic Nucleosides with a Constrained Bicyclo[2.2.1]Heptane Fragment as a Glycoside Moiety
New Carbocyclic Nucleosides with a Constrained Bicyclo[2.2.1]Heptane Fragment as a Glycoside Moiety Open
Nucleosides with a norbornane fragment as sugar moiety (Figure 1) were found to have antiviral and anticancer activity [1]. [...]