Cristián Vilos
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View article: Zeolite Nanoparticles Loaded with 2-Methoxystradiol as a Novel Drug Delivery System for the Prostate Cancer Therapy
Zeolite Nanoparticles Loaded with 2-Methoxystradiol as a Novel Drug Delivery System for the Prostate Cancer Therapy Open
The estrogen metabolite 2-methoxyestradiol (2ME) is a promissory anticancer drug mainly because of its pro-apoptotic properties in cancer cells. However, the therapeutic use of 2ME has been hampered due to its low solubility and bioavailab…
View article: The Human Dermis as a Target of Nanoparticles for Treating Skin Conditions
The Human Dermis as a Target of Nanoparticles for Treating Skin Conditions Open
Skin has a preventive role against any damage raised by harmful microorganisms and physical and chemical assaults from the external environment that could affect the body’s internal organs. Dermis represents the main section of the skin, a…
View article: Potassium Channels as a Target for Cancer Therapy: Current Perspectives
Potassium Channels as a Target for Cancer Therapy: Current Perspectives Open
Potassium (K+) channels are highly regulated membrane proteins that control the potassium ion flux and respond to different cellular stimuli. These ion channels are grouped into three major families, Kv (voltage-gated K+ channel), Kir (inw…
View article: Development of a PHBV nanoparticle as a peptide vehicle for NOD1 activation
Development of a PHBV nanoparticle as a peptide vehicle for NOD1 activation Open
NOD1 is an intracellular receptor that, when activated, induces gene expression of pro-inflammatory factors promoting macrophages and neutrophils recruitment at the infection site. However, iE-DAP, the dipeptide agonist that promotes this …
View article: The Critical Role of Oxidative Stress in Sarcopenic Obesity
The Critical Role of Oxidative Stress in Sarcopenic Obesity Open
Sarcopenic obesity (SO) is a combination of obesity and sarcopenia that primarily develops in older people. Patients with SO have high fat mass, low muscle mass, low muscle strength, and low physical function. SO relates to metabolic syndr…
View article: Active acetylcholine receptors prevent the atrophy of skeletal muscles and favor reinnervation
Active acetylcholine receptors prevent the atrophy of skeletal muscles and favor reinnervation Open
Denervation of skeletal muscles induces severe muscle atrophy, which is preceded by cellular alterations such as increased plasma membrane permeability, reduced resting membrane potential and accelerated protein catabolism. The factors tha…
View article: COMPUTATIONAL STUDY OF HYBRID PLA-PEG NANOPARTICLES AS ANTIPLATELET DRUG CARRIERS
COMPUTATIONAL STUDY OF HYBRID PLA-PEG NANOPARTICLES AS ANTIPLATELET DRUG CARRIERS Open
In recent years, the use of drug delivery systems based on polymeric nanoparticles (NPs) has generated innovative strategies for several diseases1,2. Polylactic acid (PLA) is one of the most commonly used polymers for the synthesis of NPs3…
View article: Nanotechnology in Preclinical and Clinical Drug Development
Nanotechnology in Preclinical and Clinical Drug Development Open
Nanotechnology is generating a strong impact in preclinical and clinical drug development. The diversity of current nanotechnologies offers a broad platform used to enhance the performance of drug discovery screening, to develop sensitive …
View article: Atomic-level characterization and cilostazol affinity of poly(lactic acid) nanoparticles conjugated with differentially charged hydrophilic molecules
Atomic-level characterization and cilostazol affinity of poly(lactic acid) nanoparticles conjugated with differentially charged hydrophilic molecules Open
Nanotherapeutics is a promising field for numerous diseases and represents the forefront of modern medicine. In the present work, full atomistic computer simulations were applied to study poly(lactic acid) (PLA) nanoparticles conjugated wi…
View article: Role of Oxidative Stress as Key Regulator of Muscle Wasting during Cachexia
Role of Oxidative Stress as Key Regulator of Muscle Wasting during Cachexia Open
Skeletal muscle atrophy is a pathological condition mainly characterized by a loss of muscular mass and the contractile capacity of the skeletal muscle as a consequence of muscular weakness and decreased force generation. Cachexia is defin…
View article: Bioinspired Heparin Nanosponge Prepared by Photo-crosslinking for Controlled Release of Growth Factors
Bioinspired Heparin Nanosponge Prepared by Photo-crosslinking for Controlled Release of Growth Factors Open
Growth factors have great therapeutic potential for various disease therapy and tissue engineering applications. However, their clinical efficacy is hampered by low bioavailability, rapid degradation in vivo and non-specific biodistributio…
View article: Angiogenesis and Tumor Progression Inhibition of Cyclooxygenase-2 Selective Inhibitor Celecoxib Associated with Poly (lactic-co-glycolic acid) in Tumor Cell Line Resistant to Chemotherapy
Angiogenesis and Tumor Progression Inhibition of Cyclooxygenase-2 Selective Inhibitor Celecoxib Associated with Poly (lactic-co-glycolic acid) in Tumor Cell Line Resistant to Chemotherapy Open
© 2017, Universidad de la Frontera. All rights reserved. Although, antineoplastic therapies have now been developed reduction of tumor progression, it is necessary to find new therapeutic alternatives to suppress angiogenesis. Thus celecox…
View article: Targeted Nanoparticles for Colorectal Cancer
Targeted Nanoparticles for Colorectal Cancer Open
Colorectal cancer (CRC) is highly prevalent worldwide, and despite notable progress in treatment still leads to significant morbidity and mortality. The use of nanoparticles as a drug delivery system has become one of the most promising st…
View article: Targeted Interleukin-10 Nanotherapeutics Developed with a Microfluidic Chip Enhance Resolution of Inflammation in Advanced Atherosclerosis
Targeted Interleukin-10 Nanotherapeutics Developed with a Microfluidic Chip Enhance Resolution of Inflammation in Advanced Atherosclerosis Open
Inflammation is an essential protective biological response involving a coordinated cascade of signals between cytokines and immune signaling molecules that facilitate return to tissue homeostasis after acute injury or infection. However, …