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View article: Real-life reliability of plasma pTau181, Aβ <sub>42</sub> /Aβ <sub>40</sub> , and pTau181/Aβ <sub>42</sub> measured by Lumipulse G600II in predicting cerebrospinal fluid amyloid status
Real-life reliability of plasma pTau181, Aβ <sub>42</sub> /Aβ <sub>40</sub> , and pTau181/Aβ <sub>42</sub> measured by Lumipulse G600II in predicting cerebrospinal fluid amyloid status Open
Background Alzheimer's disease (AD) is the most common neurodegenerative dementia, with diagnosis traditionally reliant on clinical criteria. Cerebrospinal fluid (CSF) biomarkers like pTau181 and Aβ 42 /Aβ 40 ratio significantly improve di…
View article: Central Nervous System Disorders with Auto-Antibodies in People Living with HIV
Central Nervous System Disorders with Auto-Antibodies in People Living with HIV Open
People living with HIV (PLWH) may present atypical neurological complications. Recently, autoimmune manifestations of the central nervous system (CNS) have been described. We retrospectively described the features of PLWH presenting with a…
View article: Changes in Cerebrospinal Fluid, Liver and Intima-media-thickness Biomarkers in Patients with HIV-associated Neurocognitive Disorders Randomized to a Less Neurotoxic Treatment Regimen
Changes in Cerebrospinal Fluid, Liver and Intima-media-thickness Biomarkers in Patients with HIV-associated Neurocognitive Disorders Randomized to a Less Neurotoxic Treatment Regimen Open
The prevalence of neurocognitive impairment in people living with HIV is estimated between 30 and 50%. The pathogenesis of HIV-associated neurocognitive disorders is complex and multifactorial. Aim of the study was to measure the change in…
View article: A Novel <i>PSEN1</i> Variant Leading to Posterior Cortical Atrophy: A Case Report
A Novel <i>PSEN1</i> Variant Leading to Posterior Cortical Atrophy: A Case Report Open
We describe a 52-year-old patient with a progressive visuospatial disorder and apraxia. Neuropsychological assessment, neuroradiological findings, and Alzheimer’s disease (AD) core biomarker assay on cerebrospinal fluid led to a diagnosis …
View article: Cerebrospinal fluid CXCL13 identifies a subgroup of people living with HIV with prominent intrathecal synthesis, immune activation, and neurocognitive impairment regardless of effective antiretroviral therapy
Cerebrospinal fluid CXCL13 identifies a subgroup of people living with HIV with prominent intrathecal synthesis, immune activation, and neurocognitive impairment regardless of effective antiretroviral therapy Open
Background Plasma C-X-C-motif chemokine ligand-13 (CXCL13) has been linked to disease progression and mortality in people living with HIV (PLWH) and is a candidate target for immune-based strategies for HIV cure. Its role in central nervou…
View article: Patterns of Cerebrospinal Fluid Alzheimer’s Dementia Biomarkers in People Living with HIV: Cross-Sectional Study on Associated Factors According to Viral Control, Neurological Confounders and Neurocognition
Patterns of Cerebrospinal Fluid Alzheimer’s Dementia Biomarkers in People Living with HIV: Cross-Sectional Study on Associated Factors According to Viral Control, Neurological Confounders and Neurocognition Open
People living with HIV (PLWH) age with an excess burden of comorbidities that may increase the incidence of age-related complications. There is controversy surrounding the hypothesis that HIV can accelerate neurodegeneration and Alzheimer’…
View article: Low cerebrospinal fluid Amyloid-βeta 1–42 in patients with tuberculous meningitis
Low cerebrospinal fluid Amyloid-βeta 1–42 in patients with tuberculous meningitis Open
View article: Blood–Brain Barrier Impairment in Patients Living with HIV: Predictors and Associated Biomarkers
Blood–Brain Barrier Impairment in Patients Living with HIV: Predictors and Associated Biomarkers Open
Despite the substantial changes resulting from the introduction of combination antiretroviral therapy (cART), the prevalence of HIV-associated neurocognitive disorders (HAND) remains substantial. Blood–brain barrier impairment (BBBi) is a …
View article: Low Cerebrospinal Fluid Beta Amyloid1-42 in Patients with Tuberculous Meningitis
Low Cerebrospinal Fluid Beta Amyloid1-42 in Patients with Tuberculous Meningitis Open
Background Tuberculous meningitis (TBM) is an important disease leading to morbidity, disability and mortality that primarily affects children and immune-depressed patients. Specific neuromarkers predicting outcomes, severity and inflammat…
View article: Low Cerebrospinal Fluid Beta Amyloid1-42 in Patients with Tubercoulous Meningitis
Low Cerebrospinal Fluid Beta Amyloid1-42 in Patients with Tubercoulous Meningitis Open
Introduction Tubercolous meningitis (TBM) is an important disease leading to morbidity, disability and mortality that primarily affects children and immune-depressed patients. Specific neuromarkers predicting outcomes, severity and inflamm…
View article: Dual antiretroviral therapies are effective and safe regimens in the central nervous system of neurologically symptomatic people living with HIV
Dual antiretroviral therapies are effective and safe regimens in the central nervous system of neurologically symptomatic people living with HIV Open
Objective: Aim of this study was to compare cerebrospinal fluid (CSF) virological control, biomarkers and neurocognition of neurologically symptomatic patients on dual antiretroviral therapies (dual therapy) vs. 2 nucleoside reverse transc…
View article: Presence of Epstein–Barr virus DNA in cerebrospinal fluid is associated with greater HIV RNA and inflammation
Presence of Epstein–Barr virus DNA in cerebrospinal fluid is associated with greater HIV RNA and inflammation Open
Objective: The current study aimed to investigate whether cerebrospinal fluid (CSF) Epstein–Barr virus (EBV) or cytomegalovirus (CMV) DNA was associated with viral, inflammatory and neuronal damage biomarkers in people living with HIV (PLW…
View article: Clinical and neuropathological phenotype associated with the novel V189I mutation in the prion protein gene
Clinical and neuropathological phenotype associated with the novel V189I mutation in the prion protein gene Open
View article: Epstein-Barr Virus May Contribute to Central Nervous System Involvement in HIV-positive Individuals
Epstein-Barr Virus May Contribute to Central Nervous System Involvement in HIV-positive Individuals Open
Epstein-Barr virus (EBV) often accesses the central nervous system (CNS) where it may lead to blood brain barrier (BBB) integrity disruption, facilitating the migration of immune cells into brain parenchyma. Our aim was to study the associ…
View article: A large genomic deletion leads to enhancer adoption by the lamin B1 gene: a second path to autosomal dominant adult-onset demyelinating leukodystrophy (ADLD)
A large genomic deletion leads to enhancer adoption by the lamin B1 gene: a second path to autosomal dominant adult-onset demyelinating leukodystrophy (ADLD) Open
Chromosomal rearrangements with duplication of the lamin B1 (LMNB1) gene underlie autosomal dominant adult-onset demyelinating leukodystrophy (ADLD), a rare neurological disorder in which overexpression of LMNB1 causes progressive central …