Cristiana Caliceti
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View article: Upcycling of Citrus Waste by Natural Deep Eutectic Solvents: Green Extraction of Bioactive Compounds with Antioxidant and Regenerative Properties on Human Keratinocytes
Upcycling of Citrus Waste by Natural Deep Eutectic Solvents: Green Extraction of Bioactive Compounds with Antioxidant and Regenerative Properties on Human Keratinocytes Open
Background: The citrus processing industry generates over 40 million tons of waste annually, representing a significant environmental challenge. Citrus by-products are rich in bioactive compounds with proven health benefits. This study aim…
View article: The Role of Antioxidant Compounds from Citrus Waste in Modulating Neuroinflammation: A Sustainable Solution
The Role of Antioxidant Compounds from Citrus Waste in Modulating Neuroinflammation: A Sustainable Solution Open
In normal conditions, neuroinflammation induces microglia and astrocyte activation to maintain brain homeostasis. However, excessive or prolonged neuroinflammation can inflict harmful damage on brain tissue. Numerous factors can trigger ch…
View article: Anti-Inflammatory, Antioxidant and Antibacterial Properties of Tomato Skin and Pomegranate Peel Extracts: A Sustainable Approach for Oral Health Care
Anti-Inflammatory, Antioxidant and Antibacterial Properties of Tomato Skin and Pomegranate Peel Extracts: A Sustainable Approach for Oral Health Care Open
Agricultural food waste and by-products could provide high-value compounds that positively affect human and environmental health, thus representing promising ingredients for cosmeceutical products. This study explores the biological activi…
View article: Sulfated Bile Acids in Serum as Potential Biomarkers of Disease Severity and Mortality in COVID-19
Sulfated Bile Acids in Serum as Potential Biomarkers of Disease Severity and Mortality in COVID-19 Open
The fight against coronavirus disease 2019 (COVID-19) continues. Since the pandemic’s onset, several biomarkers have been proposed to assess the diagnosis and prognosis of this disease. This research aimed to identify potential disease sev…
View article: From Waste to Health: Olive Mill Wastewater for Cardiovascular Disease Prevention
From Waste to Health: Olive Mill Wastewater for Cardiovascular Disease Prevention Open
Waste from the agri-food chain represents a valuable reservoir of organic compounds with health-promoting properties. Momast Plus 30 Bio (MP30B) is a derivative obtained from olive-oil wastewater. Its enrichment in hydroxytyrosol (HT) via …
View article: Promising Effects of Novel Supplement Formulas in Preventing Skin Aging in 3D Human Keratinocytes
Promising Effects of Novel Supplement Formulas in Preventing Skin Aging in 3D Human Keratinocytes Open
Dietary intervention is considered a safe preventive strategy to slow down aging. This study aimed to evaluate the protective effects of a commercially available supplement and six simpler formulations against DNA damage in 3D human kerati…
View article: Bile Acids and Bilirubin Role in Oxidative Stress and Inflammation in Cardiovascular Diseases
Bile Acids and Bilirubin Role in Oxidative Stress and Inflammation in Cardiovascular Diseases Open
Bile acids (BAs) and bilirubin, primarily known for their role in lipid metabolism and as heme catabolite, respectively, have been found to have diverse effects on various physiological processes, including oxidative stress and inflammatio…
View article: Emerging Microfluidic Tools for Simultaneous Exosomes and Cargo Biosensing in Liquid Biopsy: New Integrated Miniaturized FFF-Assisted Approach for Colon Cancer Diagnosis
Emerging Microfluidic Tools for Simultaneous Exosomes and Cargo Biosensing in Liquid Biopsy: New Integrated Miniaturized FFF-Assisted Approach for Colon Cancer Diagnosis Open
The early-stage diagnosis of cancer is a crucial clinical need. The inadequacies of surgery tissue biopsy have prompted a transition to a less invasive profiling of molecular biomarkers from biofluids, known as liquid biopsy. Exosomes are …
View article: Treatment with PCSK9 Inhibitor Evolocumab Improves Vascular Oxidative Stress and Arterial Stiffness in Hypercholesterolemic Patients with High Cardiovascular Risk
Treatment with PCSK9 Inhibitor Evolocumab Improves Vascular Oxidative Stress and Arterial Stiffness in Hypercholesterolemic Patients with High Cardiovascular Risk Open
Atherosclerosis and atherosclerotic-related cardiovascular diseases (ASCVD) are characterized by high serum levels of low-density lipoprotein cholesterol (LDL-C) that can promote the generation of reactive oxygen species (ROS). To answer t…
View article: Agri-Food Waste from Apple, Pear, and Sugar Beet as a Source of Protective Bioactive Molecules for Endothelial Dysfunction and Its Major Complications
Agri-Food Waste from Apple, Pear, and Sugar Beet as a Source of Protective Bioactive Molecules for Endothelial Dysfunction and Its Major Complications Open
Endothelial damage is recognized as the initial step that precedes several cardiovascular diseases (CVD), such as atherosclerosis, hypertension, and coronary artery disease. It has been demonstrated that the best treatment for CVD is preve…
View article: New Insights into Bile Acids Related Signaling Pathways in the Onset of Colorectal Cancer
New Insights into Bile Acids Related Signaling Pathways in the Onset of Colorectal Cancer Open
Colorectal cancer (CRC) ranks as the second among the causes of tumor death worldwide, with an estimation of 1.9 million new cases in 2020 and more than 900,000 deaths. This rate might increase by 60% over the next 10 years. These data are…
View article: Fermentation of Vaccinium floribundum Berries with Lactiplantibacillus plantarum Reduces Oxidative Stress in Endothelial Cells and Modulates Macrophages Function
Fermentation of Vaccinium floribundum Berries with Lactiplantibacillus plantarum Reduces Oxidative Stress in Endothelial Cells and Modulates Macrophages Function Open
Accumulating evidence suggests that high consumption of natural antioxidants promotes health by reducing oxidative stress and, thus, the risk of developing cardiovascular diseases. Similarly, fermentation of natural compounds with lactic a…
View article: Grape Pomace for Topical Application: Green NaDES Sustainable Extraction, Skin Permeation Studies, Antioxidant and Anti-Inflammatory Activities Characterization in 3D Human Keratinocytes
Grape Pomace for Topical Application: Green NaDES Sustainable Extraction, Skin Permeation Studies, Antioxidant and Anti-Inflammatory Activities Characterization in 3D Human Keratinocytes Open
Food waste is a global problem due to its environmental and economic impact, so there is great demand for the exploitation of new functional applications. The winemaking process leads to an incomplete extraction of high-value compounds, le…
View article: Effect of Lactobacillus acidophilus Fermented Broths Enriched with Eruca sativa Seed Extracts on Intestinal Barrier and Inflammation in a Co-Culture System of an Enterohemorrhagic Escherichia coli and Human Intestinal Cells
Effect of Lactobacillus acidophilus Fermented Broths Enriched with Eruca sativa Seed Extracts on Intestinal Barrier and Inflammation in a Co-Culture System of an Enterohemorrhagic Escherichia coli and Human Intestinal Cells Open
Lactic acid bacteria (LAB) “fermentates” confer a beneficial effect on intestinal function. However, the ability of new fermentations to improve LAB broth activity in preventing pathogen-induced intestinal inflammation and barrier dysfunct…
View article: New Trends in Antioxidant Compounds: A Precise Nutraceutical in Cardiometabolic Disorders
New Trends in Antioxidant Compounds: A Precise Nutraceutical in Cardiometabolic Disorders Open
Cardiometabolic disorders are among the leading causes of morbidity and mortality in the western world. The most cost-effective preventive approach still remains a personalized diet and physical activity, but novel therapeutic approaches a…
View article: The Use of Nutraceuticals to Counteract Atherosclerosis: The Role of the Notch Pathway
The Use of Nutraceuticals to Counteract Atherosclerosis: The Role of the Notch Pathway Open
Despite the currently available pharmacotherapies, today, thirty percent of worldwide deaths are due to cardiovascular diseases (CVDs), whose primary cause is atherosclerosis, an inflammatory disorder characterized by the buildup of lipid …
View article: Peptides from Cauliflower By-Products, Obtained by an Efficient, Ecosustainable, and Semi-Industrial Method, Exert Protective Effects on Endothelial Function
Peptides from Cauliflower By-Products, Obtained by an Efficient, Ecosustainable, and Semi-Industrial Method, Exert Protective Effects on Endothelial Function Open
The large amount of cauliflower industry waste represents an unexplored source of bioactive compounds. In this work, peptide hydrolysates from cauliflower leaves were characterized by combined bioanalytical approaches. Twelve peptide fract…
View article: P029 Serum bile acids profiling in IBD patients treated with anti-TNFs
P029 Serum bile acids profiling in IBD patients treated with anti-TNFs Open
Inflammatory bowel diseases (IBD), ulcerative colitis (UC) and Crohn’s disease (CD), represents chronic conditions with a deficient intestinal absorption. This study represents the first attempt to screenshot bile acids (BAs) in a large co…
View article: The fermentation with lactic acid bacteria further enhances the immunomodulatory and antioxidant properties of a Carica Papaya Linn formulation in comparison with yeast fermentation
The fermentation with lactic acid bacteria further enhances the immunomodulatory and antioxidant properties of a Carica Papaya Linn formulation in comparison with yeast fermentation Open
Background : Dietary supplements of Carica papaya Linn fermented with yeast using a biotechnological process have well recognized positive effects on immunological, hematological, inflammatory, and oxidative stress parameters, utilized a…
View article: Heart rate reduction with ivabradine in the early phase of atherosclerosis is protective in the endothelium of ApoE-deficient mice.
Heart rate reduction with ivabradine in the early phase of atherosclerosis is protective in the endothelium of ApoE-deficient mice. Open
Ivabradine, a heart rate reducing agent, protects the vascular system by unidentified mechanisms. We sought to determine the effects of the treatment with ivabradine, started before plaque formation, on early transcriptional changes and en…
View article: Comparative study of the antioxidant and immunomodulant activities between yeast and lab fermented papaya
Comparative study of the antioxidant and immunomodulant activities between yeast and lab fermented papaya Open
Background: Dietary supplements of Carica papaya Linn fermented with yeast using a biotechnological process have well recognized positive effects on immunological, hematological, inflammatory, and oxidative stress parameters, utilized as b…
View article: Role of Natural Compounds in Oxidative Stress and Inflammation Linked to Cardiometabolic Disorders: From Biochemical Aspects to Clinical Evidences
Role of Natural Compounds in Oxidative Stress and Inflammation Linked to Cardiometabolic Disorders: From Biochemical Aspects to Clinical Evidences Open
The most cost-effective preventive approach still remains diet and physical activity, also in people without a history of cardiovascular disease. However, lifestyle programs are often difficult to follow for long periods of time, and chang…