Cristiana L. Pires
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View article: Production of parsley and pennyroyal with an African catfish-based aquaponics partially fed with yellow mealworms - Tenebrio molitor
Production of parsley and pennyroyal with an African catfish-based aquaponics partially fed with yellow mealworms - Tenebrio molitor Open
Insects can be used as alternative protein/food sources. Here, a novel aquaponic system based on the African catfish (Clarias gariepinus) fed with 30% of yellow mealworms (YM) (Tenebrio molitor) as substitute feed to 100% of fish meal (FM)…
View article: Improving the Accuracy of Permeability Data to Gain Predictive Power: Assessing Sources of Variability in Assays Using Cell Monolayers
Improving the Accuracy of Permeability Data to Gain Predictive Power: Assessing Sources of Variability in Assays Using Cell Monolayers Open
The ability to predict the rate of permeation of new compounds across biological membranes is of high importance for their success as drugs, as it determines their efficacy, pharmacokinetics, and safety profile. In vitro permeability assay…
View article: Re-Use of Caco-2 Monolayers for a Higher Throughput Assessment of Drug Permeability – Methodology and Validation for Passive Permeation
Re-Use of Caco-2 Monolayers for a Higher Throughput Assessment of Drug Permeability – Methodology and Validation for Passive Permeation Open
Evaluation of drug permeability using cell monolayers is an important in vitro assay in the process of drug development, to identify compounds with favourable pharmacokinetics that may proceed to in vivo studies. When allowed to differenti…
View article: Nutrient‐efficient catfish‐based aquaponics for producing lamb's lettuce at two light intensities
Nutrient‐efficient catfish‐based aquaponics for producing lamb's lettuce at two light intensities Open
BACKGROUND Aquaponic systems are sustainable processes of managing water and nutrients for food production. An innovate nutrient‐efficient catfish‐based ( Clarias gariepinus ) aquaponics system was implemented for producing two cultivars o…
View article: Nutritive Value and Bioactivities of a Halophyte Edible Plant: Crithmum maritimum L. (Sea Fennel)
Nutritive Value and Bioactivities of a Halophyte Edible Plant: Crithmum maritimum L. (Sea Fennel) Open
Crithmum maritimum L. (sea fennel), an edible xerophyte of coastal habitats, is considered an emerging cash crop for biosaline agriculture due to its salt-tolerance ability and potential applications in the agri-food sector. Here, the nutr…
View article: Effect of Coffee on the Bioavailability of Sterols
Effect of Coffee on the Bioavailability of Sterols Open
Absorption at the intestinal epithelium is a major determinant of cholesterol levels in the organism, influencing the entry of dietary cholesterol and the excretion of endogenous cholesterol. Several strategies are currently being followed…
View article: Bioavailability and Biotransformation of Paralytic Shellfish Toxins Assessed by Permeability Assays Using Caco-2 Monolayers
Bioavailability and Biotransformation of Paralytic Shellfish Toxins Assessed by Permeability Assays Using Caco-2 Monolayers Open
Caco-2 cells are well established models of intestinal epithelium, being routinely used to evaluate toxicity and bioavailability. Although usually overlooked, Caco-2 monolayers may also be used to assess biotransformation by epithelial cel…
View article: Re-Use of Caco-2 Monolayers in Permeability Assays—Validation Regarding Cell Monolayer Integrity
Re-Use of Caco-2 Monolayers in Permeability Assays—Validation Regarding Cell Monolayer Integrity Open
Caco-2 monolayers are a common in vitro model used to evaluate human intestinal absorption. The reference protocol requires 21 days post-seeding to establish a stable and confluent cell monolayer, which is used in a single permeability ass…