Cristina Airoldi
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View article: Advanced NMR Screening: Unveiling Bioactive Compounds in Complex Molecular Mixtures
Advanced NMR Screening: Unveiling Bioactive Compounds in Complex Molecular Mixtures Open
Nuclear magnetic resonance (NMR) spectroscopy represents an indispensable analytical tool for the structural and functional characterization of complex molecular mixtures, with significant applications in metabolomics, natural product disc…
View article: A modular model integrating metabolism, growth, and cell cycle predicts that fermentation is required to modulate cell size in yeast populations
A modular model integrating metabolism, growth, and cell cycle predicts that fermentation is required to modulate cell size in yeast populations Open
For unicellular organisms, the reproduction rate and growth are crucial fitness determinants and functional manifestations of the organism genotype. Using the budding yeast Saccharomyces cerevisiae as a model organism, we integrated metabo…
View article: Xanthohumol destabilizes the structure of amyloid-β (Aβ) oligomers and promotes the formation of high-molecular-weight amorphous aggregates
Xanthohumol destabilizes the structure of amyloid-β (Aβ) oligomers and promotes the formation of high-molecular-weight amorphous aggregates Open
This study provides a comprehensive structural analysis of prenylflavonoids (PFs) interaction with Aβ1-42 oligomers, revealing their potential to modulate amyloid peptide aggregation pathways. Among the tested PFs, xanthohumol (XN), isoxan…
View article: Multi-pathway blood biomarkers to target and monitor multidimensional prevention of cognitive and functional decline (nested in the IN-TeMPO study framed within the world-wide FINGERS network)
Multi-pathway blood biomarkers to target and monitor multidimensional prevention of cognitive and functional decline (nested in the IN-TeMPO study framed within the world-wide FINGERS network) Open
Background As the population ages, the identification of preventive strategies able to delay cognitive and functional decline associated with aging represents a major challenge. To date, multidimensional approaches seem to be effective in …
View article: Clustering Zwitterionic Amino Acids at the Upper Rim of Cone Calix[4]arene Triggers the Selective Recognition of Gram‐Negative Bacterial Envelope
Clustering Zwitterionic Amino Acids at the Upper Rim of Cone Calix[4]arene Triggers the Selective Recognition of Gram‐Negative Bacterial Envelope Open
Eleven calix[4]arene ligands, bearing zwitterionic α‐amino acids or charged ammonium or sulfonate/carboxylate groups, are synthesized and screened for the binding to the envelopes of three bacterial strain representatives of Gram‐positive,…
View article: Mechanistic and Structural Insights on Difluoromethyl-1,3,4-oxadiazole Inhibitors of HDAC6
Mechanistic and Structural Insights on Difluoromethyl-1,3,4-oxadiazole Inhibitors of HDAC6 Open
Histone deacetylase 6 (HDAC6) is increasingly recognized for its potential in targeted disease therapy. This study delves into the mechanistic and structural nuances of HDAC6 inhibition by difluoromethyl-1,3,4-oxadiazole (DFMO) derivatives…
View article: Cell-Free and In Vivo Characterization of the Inhibitory Activity of <i>Lavado</i> Cocoa Flavanols on the Amyloid Protein Ataxin-3: Toward New Approaches against Spinocerebellar Ataxia Type 3
Cell-Free and In Vivo Characterization of the Inhibitory Activity of <i>Lavado</i> Cocoa Flavanols on the Amyloid Protein Ataxin-3: Toward New Approaches against Spinocerebellar Ataxia Type 3 Open
Spinocerebellar ataxia type 3 (SCA3) is a neurodegenerative disorder characterized by ataxia and other neurological manifestations, with a poor prognosis and a lack of effective therapies. The amyloid aggregation of the ataxin-3 protein is…
View article: A modular model integrating metabolism, growth, and cell cycle predicts that fermentation is required to modulate cell size in yeast populations
A modular model integrating metabolism, growth, and cell cycle predicts that fermentation is required to modulate cell size in yeast populations Open
Summary For unicellular organisms, the reproduction rate and growth are crucial determinants of fitness and, therefore, essential functional manifestations of the organism genotype. Using the budding yeast Saccharomyces cerevisiae as a mod…
View article: Adjuvant Effect of Cinnamon Polyphenolic Components in Colorectal Cancer Cell Lines
Adjuvant Effect of Cinnamon Polyphenolic Components in Colorectal Cancer Cell Lines Open
Colorectal cancer (CRC) is the second-leading cause of cancer death, with a worldwide incidence rate constantly increasing; thus, new strategies for its prevention or treatment are needed. Here, we describe the adjuvant effect of the polyp…
View article: Antarctic Soil Metabolomics: A Pilot Study
Antarctic Soil Metabolomics: A Pilot Study Open
In Antarctica, ice-free areas can be found along the coast, on mountain peaks, and in the McMurdo Dry Valleys, where microorganisms well-adapted to harsh conditions can survive and reproduce. Metabolic analyses can shed light on the surviv…
View article: CCDC 2203474: Experimental Crystal Structure Determination
CCDC 2203474: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Masthead - Full issue pdf
Masthead - Full issue pdf Open
of the Local Organizing Committee IUPAC|CHAINS 2023 I t will still take a few more months before I can officially welcome you to IUPAC|CHAINS 2023, but since the preparations are already in full swing, it feels like we are getting close to…
View article: <b> 1 <sup>st</sup> Italian-French International Conference on Magnetic Resonance in Milan, 2022 </b>
<b> 1 <sup>st</sup> Italian-French International Conference on Magnetic Resonance in Milan, 2022 </b> Open
View article: Cheese-whey permeate improves the fitness of Escherichia coli cells during recombinant protein production
Cheese-whey permeate improves the fitness of Escherichia coli cells during recombinant protein production Open
View article: Conformationally Restricted β‐Sheet Breaker Peptides Incorporating Cyclic α‐Methylisoserine Sulfamidates
Conformationally Restricted β‐Sheet Breaker Peptides Incorporating Cyclic α‐Methylisoserine Sulfamidates Open
Peptides containing variations of the β‐amyloid hydrophobic core and five‐membered sulfamidates derived from β‐amino acid α‐methylisoserine have been synthesized and fully characterized in the gas phase, solid state and in aqueous solution…
View article: Alzheimer's Disease Prevention through Natural Compounds: Cell- Free, In Vitro, and In Vivo Dissection of Hop (Humulus lupulus L.) Multitarget Activity
Alzheimer's Disease Prevention through Natural Compounds: Cell- Free, In Vitro, and In Vivo Dissection of Hop (Humulus lupulus L.) Multitarget Activity Open
The relevant social and economic costs associated with aging and neurodegenerative diseases, particularly Alzheimer’s disease (AD), entail considerable efforts to develop effective preventive and therapeutic strategies. The search for natu…
View article: Alzheimer’s Disease Prevention through Natural Compounds: Cell-Free<i>, In Vitro</i>, and <i>In Vivo</i> Dissection of Hop (<i>Humulus lupulus</i> L.) Multitarget Activity
Alzheimer’s Disease Prevention through Natural Compounds: Cell-Free<i>, In Vitro</i>, and <i>In Vivo</i> Dissection of Hop (<i>Humulus lupulus</i> L.) Multitarget Activity Open
The relevant social and economic costs associated with aging and neurodegenerative diseases, particularly Alzheimer's disease (AD), entail considerable efforts to develop effective preventive and therapeutic strategies. The search for natu…
View article: NMR-Driven Identification of Cinnamon Bud and Bark Components With Anti-Aβ Activity
NMR-Driven Identification of Cinnamon Bud and Bark Components With Anti-Aβ Activity Open
The anti-Alzheimer disease (AD) activity reported for an aqueous cinnamon bark extract prompted us to investigate and compare the anti-amyloidogenic properties of cinnamon extracts obtained from both bark and bud, the latter being a very l…
View article: Green and Roasted Coffee Extracts Inhibit Interferon-β Release in LPS-Stimulated Human Macrophages
Green and Roasted Coffee Extracts Inhibit Interferon-β Release in LPS-Stimulated Human Macrophages Open
The anti-inflammatory activity of coffee extracts is widely recognized and supported by experimental evidence, in both in vitro and in vivo settings, mainly murine models. Here, we investigated the immunomodulatory properties of coffee ext…
View article: SMA libraries for metabolite NMR-based identification and quantification in cinnamon extracts
SMA libraries for metabolite NMR-based identification and quantification in cinnamon extracts Open
Metabolite libraries built from NMR spectra for the metabolomics analysis of cinnamon extracts, using the Simple Mixture Analysis (SMA) tool implemented in MestreNova 14.1 software.
View article: Cross-Linking Effects Dictate the Preference of Galectins to Bind LacNAc-Decorated HPMA Copolymers
Cross-Linking Effects Dictate the Preference of Galectins to Bind LacNAc-Decorated HPMA Copolymers Open
The interaction of multi-LacNAc (Galβ1-4GlcNAc)-containing N-(2-hydroxypropyl) methacrylamide (HPMA) copolymers with human galectin-1 (Gal-1) and the carbohydrate recognition domain (CRD) of human galectin-3 (Gal-3) was analyzed using NMR …
View article: Tubulin binding potentially clears up Bortezomib and Carfilzomib differential neurotoxic effect
Tubulin binding potentially clears up Bortezomib and Carfilzomib differential neurotoxic effect Open
Proteasome inhibitors (PIs) represent the gold standard in the treatment of multiple myeloma. Among PIs, Bortezomib (BTZ) is frequently used as first line therapy, but peripheral neuropathy (PN), occurring approximately in 50% of patients,…
View article: Phytotoxicity, nematicidal activity and chemical constituents of Peucedanum ostruthium (L.) W.D.J.Koch (Apiaceae)
Phytotoxicity, nematicidal activity and chemical constituents of Peucedanum ostruthium (L.) W.D.J.Koch (Apiaceae) Open
View article: Targeting GRP receptor: Design, synthesis and preliminary biological characterization of new non-peptide antagonists of bombesin
Targeting GRP receptor: Design, synthesis and preliminary biological characterization of new non-peptide antagonists of bombesin Open
View article: The Multi-Level Mechanism of Action of a Pan-Ras Inhibitor Explains its Antiproliferative Activity on Cetuximab-Resistant Cancer Cells
The Multi-Level Mechanism of Action of a Pan-Ras Inhibitor Explains its Antiproliferative Activity on Cetuximab-Resistant Cancer Cells Open
Ras oncoproteins play a crucial role in the onset, maintenance, and progression of the most common and deadly human cancers. Despite extensive research efforts, only a few mutant-specific Ras inhibitors have been reported. We show that cmp…
View article: Bombesin structure in presence of SDS micelles
Bombesin structure in presence of SDS micelles Open
Structure of bombesin peptide calculated in presence of 150 mM SDS micelles at pH 7.0, 25°C. Structure was determinded by NMR spectroscopy and SA-MD. Data clearly show that, under these experimental conditions, bombesin adopts a α-helix st…
View article: Synthesis, Molecular Modeling and Biological Evaluation of Metabolically Stable Analogues of the Endogenous Fatty Acid Amide Palmitoylethanolamide
Synthesis, Molecular Modeling and Biological Evaluation of Metabolically Stable Analogues of the Endogenous Fatty Acid Amide Palmitoylethanolamide Open
Palmitoylethanolamide (PEA) belongs to the class of N-acylethanolamine and is an endogenous lipid potentially useful in a wide range of therapeutic areas; products containing PEA are licensed for use in humans as a nutraceutical, a food su…
View article: Structural Basis of Inhibition of the Pioneer Transcription Factor NF-Y by Suramin
Structural Basis of Inhibition of the Pioneer Transcription Factor NF-Y by Suramin Open
NF-Y is a transcription factor (TF) comprising three subunits (NF-YA, NF-YB, NF-YC) that binds with high specificity to the CCAAT sequence, a widespread regulatory element in gene promoters of prosurvival, cell-cycle-promoting, and metabol…
View article: Correction to: Different phytotoxic effect of Lolium multiflorum Lam. leaves against Echinochloa oryzoides (Ard.) Fritsch and Oryza sativa L.
Correction to: Different phytotoxic effect of Lolium multiflorum Lam. leaves against Echinochloa oryzoides (Ard.) Fritsch and Oryza sativa L. Open
View article: SMA libraries for metabolite identification and quantification in cocoa extracts
SMA libraries for metabolite identification and quantification in cocoa extracts Open
Metabolite libraries built from NMR spectra for natural, lavado and commercial cocoa and for two extraction procedures (hydroalcoholic and Soxhlet), using the Simple Mixture Analysis (SMA) tool implemented in MestreNova 12.4 software.