Cristina B. Lorenzini
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View article: Neuraminidase is a host‐directed approach to regulate neutrophil responses in sepsis and COVID‐19
Neuraminidase is a host‐directed approach to regulate neutrophil responses in sepsis and COVID‐19 Open
Background and Purpose Neutrophil overstimulation plays a crucial role in tissue damage during severe infections. Because pathogen‐derived neuraminidase (NEU) stimulates neutrophils, we investigated whether host NEU can be targeted to regu…
View article: Elongated neutrophil-derived structures are blood-borne microparticles formed by rolling neutrophils during sepsis
Elongated neutrophil-derived structures are blood-borne microparticles formed by rolling neutrophils during sepsis Open
Rolling neutrophils form tethers with submicron diameters. Here, we report that these tethers detach, forming elongated neutrophil-derived structures (ENDS) in the vessel lumen. We studied ENDS formation in mice and humans in vitro and in …