Cristina Bertocchi
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View article: Extracellular matrix protein signaling promotes multi-step cancer vasculogenic mimicry formation
Extracellular matrix protein signaling promotes multi-step cancer vasculogenic mimicry formation Open
View article: MODELING CELL MIGRATORY PERSISTENCE THROUGH TEMPORAL CORRELATIONS AND ANGULAR NOISE
MODELING CELL MIGRATORY PERSISTENCE THROUGH TEMPORAL CORRELATIONS AND ANGULAR NOISE Open
The persistence of cell migration is a fundamental property of motile behavior, enabling cells to maintain directionality while adapting to fluctuations and external cues. This feature underlies essential processes such as development, imm…
View article: AI-assisted imaging screening reveals mechano-molecular tissue organizers and network of signaling hubs
AI-assisted imaging screening reveals mechano-molecular tissue organizers and network of signaling hubs Open
Cadherin-mediated adhesions are crucial mechanical and signaling hubs that connect cells within a tissue and probe the mechanics of the surrounding environment. They constitute a physical link between the actin cytoskeleton of neighboring …
View article: Alternative molecular mechanisms for force transmission at adherens junctions via β-catenin-vinculin interaction
Alternative molecular mechanisms for force transmission at adherens junctions via β-catenin-vinculin interaction Open
View article: Illumination Power, Stability, and Linearity Measurements for Confocal, Widefield and Multiphoton Microscopes v1
Illumination Power, Stability, and Linearity Measurements for Confocal, Widefield and Multiphoton Microscopes v1 Open
To obtain accurate, reproducible, and interpretable data when conducting imaging experiments, it is critical to consider external factors affecting data acquisition at various steps of the experimental workflow. Illumination power and stab…
View article: Community-developed checklists for publishing images and image analyses
Community-developed checklists for publishing images and image analyses Open
View article: Community-developed checklists for publishing images and image analyses.
Community-developed checklists for publishing images and image analyses. Open
Images document scientific discoveries and are prevalent in modern biomedical research. Microscopy imaging in particular is currently undergoing rapid technological advancements. However for scientists wishing to publish the obtained image…
View article: VolumePeeler: a novel FIJI plugin for geometric tissue peeling to improve visualization and quantification of 3D image stacks
VolumePeeler: a novel FIJI plugin for geometric tissue peeling to improve visualization and quantification of 3D image stacks Open
View article: Protocol for extracting live blastoderm cells from embryos of annual killifish
Protocol for extracting live blastoderm cells from embryos of annual killifish Open
View article: Molecular Insights on Shigellosis: How the Interaction Between Invasin IpaA and Vinculin Hijacks Cellular Mechanotransduction
Molecular Insights on Shigellosis: How the Interaction Between Invasin IpaA and Vinculin Hijacks Cellular Mechanotransduction Open
With 270 million infections annually and nearly half a million death a year, shigellosis is a severe intestinal infection caused by bacteria of the Shigella family. Appearance and spread of drug-resistant strains renewed global concerns fo…
View article: A computational framework for testing hypotheses of the minimal mechanical requirements for cell aggregation using early annual killifish embryogenesis as a model
A computational framework for testing hypotheses of the minimal mechanical requirements for cell aggregation using early annual killifish embryogenesis as a model Open
Introduction: Deciphering the biological and physical requirements for the outset of multicellularity is limited to few experimental models. The early embryonic development of annual killifish represents an almost unique opportunity to inv…
View article: Community-developed checklists for publishing images and image analysis
Community-developed checklists for publishing images and image analysis Open
Images document scientific discoveries and are prevalent in modern biomedical research. Microscopy imaging in particular is currently undergoing rapid technological advancements. However for scientists wishing to publish the obtained image…
View article: Palmitic acid control of ciliogenesis modulates insulin signaling in hypothalamic neurons through an autophagy-dependent mechanism
Palmitic acid control of ciliogenesis modulates insulin signaling in hypothalamic neurons through an autophagy-dependent mechanism Open
View article: Mechanoautophagy: Synergies Between Autophagy and Cell Mechanotransduction at Adhesive Complexes
Mechanoautophagy: Synergies Between Autophagy and Cell Mechanotransduction at Adhesive Complexes Open
Cells are exposed and respond to various mechanical forces and physical cues stemming from their environment. This interaction has been seen to differentially regulate various cellular processes for maintenance of homeostasis, of which aut…
View article: Junctional ER Organization Affects Mechanotransduction at Cadherin-Mediated Adhesions
Junctional ER Organization Affects Mechanotransduction at Cadherin-Mediated Adhesions Open
Cadherin-mediated adhesions (also known as adherens junctions) are adhesive complexes that connect neighboring cells in a tissue. While the role of the actin cytoskeleton in withstanding tension at these sites of contact is well documented…
View article: Mechanobiology of Autophagy: The Unexplored Side of Cancer
Mechanobiology of Autophagy: The Unexplored Side of Cancer Open
Proper execution of cellular function, maintenance of cellular homeostasis and cell survival depend on functional integration of cellular processes and correct orchestration of cellular responses to stresses. Cancer transformation is a com…
View article: Mechanobiology of Autophagy: The Unexplored Side of Cancer
Mechanobiology of Autophagy: The Unexplored Side of Cancer Open
Proper execution of cellular function, maintenance of cellular homeostasis and cell survival depend on functional integration of cellular processes and correct orchestration of cellular responses to stresses.Cancer transformation is a comm…
View article: Author Correction: Single-cell analysis of EphA clustering phenotypes to probe cancer cell heterogeneity
Author Correction: Single-cell analysis of EphA clustering phenotypes to probe cancer cell heterogeneity Open
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
View article: Author Correction: Single-cell analysis of EphA clustering phenotypes to probe cancer cell heterogeneity
Author Correction: Single-cell analysis of EphA clustering phenotypes to probe cancer cell heterogeneity Open
View article: Single-cell analysis of EphA clustering phenotypes to probe cancer cell heterogeneity
Single-cell analysis of EphA clustering phenotypes to probe cancer cell heterogeneity Open
View article: Palmitic acid reduces the autophagic flux in hypothalamic neurons by impairing autophagosome-lysosome fusion and endolysosomal dynamics
Palmitic acid reduces the autophagic flux in hypothalamic neurons by impairing autophagosome-lysosome fusion and endolysosomal dynamics Open
High-fat diet (HFD)-induced obesity is associated with increased cancer risk. Long-term feeding with HFD increases the concentration of the saturated fatty acid palmitic acid (PA) in the hypothalamus. We previously showed that, in hypothal…
View article: Microfluidics for Cells and Other Organisms
Microfluidics for Cells and Other Organisms Open
Microfluidics-based devices play an important role in creating realistic microenvironments in which cell cultures can thrive. They can, for example, be used to monitor drug toxicity and perform medical diagnostics, and be in a static-, per…
View article: Mechanical Roles of Vinculin/β-catenin interaction in Adherens Junction
Mechanical Roles of Vinculin/β-catenin interaction in Adherens Junction Open
Summary Mechanical force transmission through the adherens junctions (AJs) are highly regulated processes essential for multicellular organization of tissues. AJ proteins such as E-cadherin, α-catenin, and vinculin have been shown to be se…
View article: Single-cell analysis of EphA clustering phenotypes to probe cancer cell heterogeneity
Single-cell analysis of EphA clustering phenotypes to probe cancer cell heterogeneity Open
Eph receptors, a family of receptor tyrosine kinases, play a crutial role in the assembly and maintenance of healthy tissues. Dysfunction in Eph signaling are causally and correlatively associated with cancer progression. In breast cancer …
View article: Integrating Microfabrication into Biological Investigations: the Benefits of Interdisciplinarity
Integrating Microfabrication into Biological Investigations: the Benefits of Interdisciplinarity Open
The advent of micro and nanotechnologies, such as microfabrication, have impacted scientific research and contributed to meaningful real-world applications, to a degree seen during historic technological revolutions. Some key areas benefit…
View article: Nanoscale architecture of cadherin-based cell adhesions
Nanoscale architecture of cadherin-based cell adhesions Open
View article: Probing the Nanoscale Architecture of Cadherin-Based Adhesions by Superresolution Microscopy
Probing the Nanoscale Architecture of Cadherin-Based Adhesions by Superresolution Microscopy Open
View article: Gap geometry dictates epithelial closure efficiency
Gap geometry dictates epithelial closure efficiency Open
View article: Regulation of epithelial cell organization by tuning cell–substrate adhesion
Regulation of epithelial cell organization by tuning cell–substrate adhesion Open
Combining live cell imaging, particle image velocimetry and numerical simulations, we show the role of extracellular matrix and intercellular adhesion on the expansion of epithelial cells.