Cristina Maccalli
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View article: The role of immune checkpoints in modulating cancer stem cells anti-tumor immune responses: implications and perspectives in cancer therapy
The role of immune checkpoints in modulating cancer stem cells anti-tumor immune responses: implications and perspectives in cancer therapy Open
View article: 250 Umbilical cord blood-derived CD19-CAR-T cells exhibit effective anti-tumor activity and demonstrate a low profile of pro-inflammatory and allograft rejection
250 Umbilical cord blood-derived CD19-CAR-T cells exhibit effective anti-tumor activity and demonstrate a low profile of pro-inflammatory and allograft rejection Open
View article: Editorial: Community series in biomarkers in the era of cancer immunotherapy: zooming in from periphery to tumor microenvironment, volume II
Editorial: Community series in biomarkers in the era of cancer immunotherapy: zooming in from periphery to tumor microenvironment, volume II Open
View article: The integrative genomic and functional immunological analyses of colorectal cancer initiating cells to modulate stemness properties and the susceptibility to immune responses
The integrative genomic and functional immunological analyses of colorectal cancer initiating cells to modulate stemness properties and the susceptibility to immune responses Open
Our study demonstrates that the modulation of miRNA-15a in CICs not only suppresses the tumorigenic properties but also enhances their visibility to the immune system by upregulating antigen presentation and reducing immunomodulatory molec…
View article: 551 Expression profiling of the inhibitory checkpoints by colorectal cancer stem cells
551 Expression profiling of the inhibitory checkpoints by colorectal cancer stem cells Open
View article: Stressed target cancer cells drive nongenetic reprogramming of CAR T cells and solid tumor microenvironment
Stressed target cancer cells drive nongenetic reprogramming of CAR T cells and solid tumor microenvironment Open
The poor efficacy of chimeric antigen receptor T-cell therapy (CAR T) for solid tumors is due to insufficient CAR T cell tumor infiltration, in vivo expansion, persistence, and effector function, as well as exhaustion, intrinsic target ant…
View article: Unlocking the secrets: exploring the influence of the aryl hydrocarbon receptor and microbiome on cancer development
Unlocking the secrets: exploring the influence of the aryl hydrocarbon receptor and microbiome on cancer development Open
View article: P065 The evolution of inflammatory bowel disease can be monitored through multi-omics characterization of gut tissues
P065 The evolution of inflammatory bowel disease can be monitored through multi-omics characterization of gut tissues Open
Background The aim of the study is to dissect the mechanisms associated with the evolution of Inflammatory Bowel Disease (IBD), including Crohn’s Disease (CD) and Ulcerative Colitis (UC) in both pediatric and adult patients, along with the…
View article: 226 ‘Off-the-shelf’ CD19-CAR-T cells generated from umbilical cord blood display superior anti-tumor fitness and lower pro-inflammatory activity as compared to peripheral blood-derived engineered T cells
226 ‘Off-the-shelf’ CD19-CAR-T cells generated from umbilical cord blood display superior anti-tumor fitness and lower pro-inflammatory activity as compared to peripheral blood-derived engineered T cells Open
Background The principal goal of this study is to generate 'off-the-shelf' CD19-CAR-T cells utilizing umbilical cord blood (UCB) as source of T lymphocytes and characterize through multi-omics their phenotype and functional properties. Met…
View article: Progress and harmonization of gene editing to treat human diseases: Proceeding of COST Action CA21113 GenE-HumDi
Progress and harmonization of gene editing to treat human diseases: Proceeding of COST Action CA21113 GenE-HumDi Open
View article: Review of: "Targeting Cancer Cell Signaling Using Precision Oncology Towards a Holistic Approach to Cancer Therapeutics"
Review of: "Targeting Cancer Cell Signaling Using Precision Oncology Towards a Holistic Approach to Cancer Therapeutics" Open
View article: Stressed target cancer cells drive nongenetic reprogramming of CAR T cells and solid tumor microenvironment
Stressed target cancer cells drive nongenetic reprogramming of CAR T cells and solid tumor microenvironment Open
The poor efficacy of chimeric antigen receptor T-cell therapy (CAR T) for solid tumors is due to insufficient CAR T cell tumor infiltration, in vivo expansion, persistence, and effector function, as well as exhaustion, intrinsic target ant…
View article: Exploring the Role of microRNAs in Glioma Progression, Prognosis, and Therapeutic Strategies
Exploring the Role of microRNAs in Glioma Progression, Prognosis, and Therapeutic Strategies Open
Gliomas, which arise from glial cells in the brain, remain a significant challenge due to their location and resistance to traditional treatments. Despite research efforts and advancements in healthcare, the incidence of gliomas has risen …
View article: Deciphering the complexities of cancer cell immune evasion: Mechanisms and therapeutic implications
Deciphering the complexities of cancer cell immune evasion: Mechanisms and therapeutic implications Open
View article: The Role of miRNAs in the Progression and Prognosis of Gliomas
The Role of miRNAs in the Progression and Prognosis of Gliomas Open
Gliomas, which arise from glial cells in the brain, remain a significant challenge due to their location and resistance to traditional treatments. Despite research efforts and advancements in healthcare, the incidence of gliomas has risen …
View article: Supplementary Data from Immunobiological Characterization of Cancer Stem Cells Isolated from Glioblastoma Patients
Supplementary Data from Immunobiological Characterization of Cancer Stem Cells Isolated from Glioblastoma Patients Open
Supplementary Data from Immunobiological Characterization of Cancer Stem Cells Isolated from Glioblastoma Patients
View article: Supplementary material from Exploiting B-cell Receptor Stereotypy to Design Tailored Immunotherapy in Chronic Lymphocytic Leukemia
Supplementary material from Exploiting B-cell Receptor Stereotypy to Design Tailored Immunotherapy in Chronic Lymphocytic Leukemia Open
Supplementary methods, Supplementary Figure 1, Supplementary Figure 2, Supplementary Figure 3, Supplementary Figure 4, Supplementary Table 1, Supplementary Table 2, Supplementary Table 3, Supplementary Table 4 Supplementary References
View article: Data from Induction of Both CD8<sup>+</sup> and CD4<sup>+</sup> T-Cell–Mediated Responses in Colorectal Cancer Patients by Colon Antigen-1
Data from Induction of Both CD8<sup>+</sup> and CD4<sup>+</sup> T-Cell–Mediated Responses in Colorectal Cancer Patients by Colon Antigen-1 Open
Purpose: Colon antigen-1 (COA-1) was recently identified as a novel antigen of colorectal cancer encoded by the UBXD5 gene. Here, we evaluated whether a specific T-cell-mediated response directed against this molecule can occ…
View article: Supplementary Data from Induction of Both CD8<sup>+</sup> and CD4<sup>+</sup> T-Cell–Mediated Responses in Colorectal Cancer Patients by Colon Antigen-1
Supplementary Data from Induction of Both CD8<sup>+</sup> and CD4<sup>+</sup> T-Cell–Mediated Responses in Colorectal Cancer Patients by Colon Antigen-1 Open
Supplementary Data from Induction of Both CD8+ and CD4+ T-Cell–Mediated Responses in Colorectal Cancer Patients by Colon Antigen-1
View article: Data from NKG2D-Mediated Antitumor Activity by Tumor-Infiltrating Lymphocytes and Antigen-Specific T-Cell Clones Isolated from Melanoma Patients
Data from NKG2D-Mediated Antitumor Activity by Tumor-Infiltrating Lymphocytes and Antigen-Specific T-Cell Clones Isolated from Melanoma Patients Open
Purpose: The role of NKG2D receptor in antitumor immunosurveillance has not been completely clarified. We addressed this issue by investigating the involvement of this receptor in tumor-specific immunologic response in melanoma pati…
View article: Data from Immunobiological Characterization of Cancer Stem Cells Isolated from Glioblastoma Patients
Data from Immunobiological Characterization of Cancer Stem Cells Isolated from Glioblastoma Patients Open
Purpose: Cancer stem cells (CSC) have been isolated from human tumors, including glioblastoma multiforme (GBM). The aims of this study were the immunobiological characterization of GBM CSCs and the assessment of whether these cells …
View article: Data from Immunobiological Characterization of Cancer Stem Cells Isolated from Glioblastoma Patients
Data from Immunobiological Characterization of Cancer Stem Cells Isolated from Glioblastoma Patients Open
Purpose: Cancer stem cells (CSC) have been isolated from human tumors, including glioblastoma multiforme (GBM). The aims of this study were the immunobiological characterization of GBM CSCs and the assessment of whether these cells …
View article: Data from Exploiting B-cell Receptor Stereotypy to Design Tailored Immunotherapy in Chronic Lymphocytic Leukemia
Data from Exploiting B-cell Receptor Stereotypy to Design Tailored Immunotherapy in Chronic Lymphocytic Leukemia Open
Purpose:Approximately 30% of patients with chronic lymphocytic leukemia (CLL) can be grouped into subsets with stereotyped B-cell receptor immunoglobulin (BcR IG) displaying remarkable similarity in the heavy complementarity-determining re…
View article: Data from NKG2D-Mediated Antitumor Activity by Tumor-Infiltrating Lymphocytes and Antigen-Specific T-Cell Clones Isolated from Melanoma Patients
Data from NKG2D-Mediated Antitumor Activity by Tumor-Infiltrating Lymphocytes and Antigen-Specific T-Cell Clones Isolated from Melanoma Patients Open
Purpose: The role of NKG2D receptor in antitumor immunosurveillance has not been completely clarified. We addressed this issue by investigating the involvement of this receptor in tumor-specific immunologic response in melanoma pati…
View article: Treatment with decitabine induces the expression of stemness markers, PD-L1 and NY-ESO-1 in colorectal cancer: potential for combined chemoimmunotherapy
Treatment with decitabine induces the expression of stemness markers, PD-L1 and NY-ESO-1 in colorectal cancer: potential for combined chemoimmunotherapy Open
Background The mechanism of tumor immune escape and progression in colorectal cancer (CRC) is widely investigated in-vitro to help understand and identify agents that might play a crucial role in response to treatment and improve the overa…
View article: Data from Exploiting B-cell Receptor Stereotypy to Design Tailored Immunotherapy in Chronic Lymphocytic Leukemia
Data from Exploiting B-cell Receptor Stereotypy to Design Tailored Immunotherapy in Chronic Lymphocytic Leukemia Open
Purpose:Approximately 30% of patients with chronic lymphocytic leukemia (CLL) can be grouped into subsets with stereotyped B-cell receptor immunoglobulin (BcR IG) displaying remarkable similarity in the heavy complementarity-determining re…
View article: Data from Induction of Both CD8<sup>+</sup> and CD4<sup>+</sup> T-Cell–Mediated Responses in Colorectal Cancer Patients by Colon Antigen-1
Data from Induction of Both CD8<sup>+</sup> and CD4<sup>+</sup> T-Cell–Mediated Responses in Colorectal Cancer Patients by Colon Antigen-1 Open
Purpose: Colon antigen-1 (COA-1) was recently identified as a novel antigen of colorectal cancer encoded by the UBXD5 gene. Here, we evaluated whether a specific T-cell-mediated response directed against this molecule can occ…
View article: Supplementary Data from NKG2D-Mediated Antitumor Activity by Tumor-Infiltrating Lymphocytes and Antigen-Specific T-Cell Clones Isolated from Melanoma Patients
Supplementary Data from NKG2D-Mediated Antitumor Activity by Tumor-Infiltrating Lymphocytes and Antigen-Specific T-Cell Clones Isolated from Melanoma Patients Open
Supplementary Data from NKG2D-Mediated Antitumor Activity by Tumor-Infiltrating Lymphocytes and Antigen-Specific T-Cell Clones Isolated from Melanoma Patients
View article: Supplementary Data from Induction of Both CD8<sup>+</sup> and CD4<sup>+</sup> T-Cell–Mediated Responses in Colorectal Cancer Patients by Colon Antigen-1
Supplementary Data from Induction of Both CD8<sup>+</sup> and CD4<sup>+</sup> T-Cell–Mediated Responses in Colorectal Cancer Patients by Colon Antigen-1 Open
Supplementary Data from Induction of Both CD8+ and CD4+ T-Cell–Mediated Responses in Colorectal Cancer Patients by Colon Antigen-1
View article: Supplementary Data from NKG2D-Mediated Antitumor Activity by Tumor-Infiltrating Lymphocytes and Antigen-Specific T-Cell Clones Isolated from Melanoma Patients
Supplementary Data from NKG2D-Mediated Antitumor Activity by Tumor-Infiltrating Lymphocytes and Antigen-Specific T-Cell Clones Isolated from Melanoma Patients Open
Supplementary Data from NKG2D-Mediated Antitumor Activity by Tumor-Infiltrating Lymphocytes and Antigen-Specific T-Cell Clones Isolated from Melanoma Patients