Cristina Murga
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View article: G Protein-Coupled Receptor Kinases Take Central Stage
G Protein-Coupled Receptor Kinases Take Central Stage Open
The relevance of the family of G protein-coupled receptor kinases (GRKs) is based on its key participation in the regulation and intracellular dynamics of the largest family of membrane receptors, namely G protein-coupled receptors (GPCRs)…
View article: Connecting nutritional deprivation and pubertal inhibition via GRK2-mediated repression of kisspeptin actions in GnRH neurons
Connecting nutritional deprivation and pubertal inhibition via GRK2-mediated repression of kisspeptin actions in GnRH neurons Open
View article: Cardiac GRK2 Protein Levels Show Sexual Dimorphism during Aging and Are Regulated by Ovarian Hormones
Cardiac GRK2 Protein Levels Show Sexual Dimorphism during Aging and Are Regulated by Ovarian Hormones Open
Cardiovascular disease (CVD) risk shows a clear sexual dimorphism with age, with a lower incidence in young women compared to age-matched men. However, this protection is lost after menopause. We demonstrate that sex-biased sensitivity to …
View article: GRK2 regulates GLP-1R-mediated early phase insulin secretion in vivo
GRK2 regulates GLP-1R-mediated early phase insulin secretion in vivo Open
View article: Additional file 2 of GRK2 regulates GLP-1R-mediated early phase insulin secretion in vivo
Additional file 2 of GRK2 regulates GLP-1R-mediated early phase insulin secretion in vivo Open
Additional file 2. Data and results supporting the conclusions of this article.
View article: Myeloid GRK2 Regulates Obesity-Induced Endothelial Dysfunction by Modulating Inflammatory Responses in Perivascular Adipose Tissue
Myeloid GRK2 Regulates Obesity-Induced Endothelial Dysfunction by Modulating Inflammatory Responses in Perivascular Adipose Tissue Open
Perivascular adipose tissue (PVAT) is increasingly being regarded as an important endocrine organ that directly impacts vessel function, structure, and contractility in obesity-associated diseases. We uncover here a role for myeloid G prot…
View article: G protein–coupled receptor kinase 2 at crossroads of metabolic and cardiovascular diseases
G protein–coupled receptor kinase 2 at crossroads of metabolic and cardiovascular diseases Open
View article: GRK2 levels in myeloid cells modulate adipose-liver crosstalk in high fat diet-induced obesity
GRK2 levels in myeloid cells modulate adipose-liver crosstalk in high fat diet-induced obesity Open
View article: Autophagy mediates hepatic GRK2 degradation to facilitate glucagon‐induced metabolic adaptation to fasting
Autophagy mediates hepatic GRK2 degradation to facilitate glucagon‐induced metabolic adaptation to fasting Open
The liver plays a key role during fasting to maintain energy homeostasis and euglycemia via metabolic processes mainly orchestrated by the insulin/glucagon ratio. We report here that fasting or calorie restriction protocols in C57BL6 mice …
View article: Sex Differences in High Fat Diet-Induced Metabolic Alterations Correlate with Changes in the Modulation of GRK2 Levels
Sex Differences in High Fat Diet-Induced Metabolic Alterations Correlate with Changes in the Modulation of GRK2 Levels Open
A differential sex-related sensitivity has been reported in obesity and insulin resistance-related cardio-metabolic diseases, with a lower incidence of these pathologies being observed in young females when compared to age-matched males. H…
View article: G Protein-Coupled Receptor Kinase 2 (GRK2) as a Potential Therapeutic Target in Cardiovascular and Metabolic Diseases
G Protein-Coupled Receptor Kinase 2 (GRK2) as a Potential Therapeutic Target in Cardiovascular and Metabolic Diseases Open
G protein-coupled receptor kinase 2 (GRK2) is a central signaling node involved in the modulation of many G protein-coupled receptors (GPCRs) and also displaying regulatory functions in other cell signaling routes. GRK2 levels and activity…
View article: Phosphorylation of p38 by GRK2 at the Docking Groove Unveils a Novel Mechanism for Inactivating p38MAPK
Phosphorylation of p38 by GRK2 at the Docking Groove Unveils a Novel Mechanism for Inactivating p38MAPK Open
View article: Obesity-induced cardiac lipid accumulation in adult mice is modulated by G protein-coupled receptor kinase 2 levels
Obesity-induced cardiac lipid accumulation in adult mice is modulated by G protein-coupled receptor kinase 2 levels Open
View article: Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1
Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1 Open
Significance Chronic pain represents a massive therapeutic challenge that requires understanding of underlying mechanisms to develop novel treatments. We show that genetic deletion of the Rap1 guanine-nucleotide exchange factor Epac1 prote…
View article: Molecular physiopathology of obesity-related diseases: multi-organ integration by GRK2
Molecular physiopathology of obesity-related diseases: multi-organ integration by GRK2 Open
Obesity is a worldwide problem that has reached epidemic proportions both in developed and developing countries. The excessive accumulation of fat poses a risk to health since it favours the development of metabolic alterations including i…
View article: Mecanismos moleculares de comunicación entre células: claves para el diseño de nuevos fármacos y la medicina personalizada
Mecanismos moleculares de comunicación entre células: claves para el diseño de nuevos fármacos y la medicina personalizada Open
View article: <i>Science Signaling</i> Podcast: 21 July 2015
<i>Science Signaling</i> Podcast: 21 July 2015 Open
Removing the kinase GRK2 prevents some of the metabolic consequences of a high-fat diet.
View article: Reversal of diet-induced obesity and insulin resistance by inducible genetic ablation of GRK2
Reversal of diet-induced obesity and insulin resistance by inducible genetic ablation of GRK2 Open
Inhibiting a protein involved in insulin and adrenergic signaling may improve metabolic disorders.