Crosby D. Rock
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View article: Reirradiation of Utracentrally Located Thoracic Tumors Using a 10-Fraction Hypofractionated Stereotactic Body Radiation Therapy Course: A Detailed Dosimetric Analysis
Reirradiation of Utracentrally Located Thoracic Tumors Using a 10-Fraction Hypofractionated Stereotactic Body Radiation Therapy Course: A Detailed Dosimetric Analysis Open
The current investigation is the first to provide detailed cumulative dosimetric data from a cohort of patients comprised entirely of ultracentrally located thoracic tumors. Despite unfavorable anatomic tumor location, given an intimate as…
View article: Income level and treatment selection in prostate cancer: analysis of a North Carolina population-based cohort
Income level and treatment selection in prostate cancer: analysis of a North Carolina population-based cohort Open
Background Disparities in treatment selection based on socioeconomic status for prostate cancer exist. However, the association between patient-level income with treatment selection priorities and treatment received has not been studied. M…
View article: Prospective metrological validation of multifrequency bioelectrical impedance analysis against volumetric imaging to identify sarcopenia in head and neck cancer patients undergoing radiation therapy
Prospective metrological validation of multifrequency bioelectrical impedance analysis against volumetric imaging to identify sarcopenia in head and neck cancer patients undergoing radiation therapy Open
Importance Depleted skeletal muscle mass (sarcopenia) is associated with decreased survival and cancer control in head and neck cancer patients treated with radiotherapy. There is a need for validated measures of body composition that can …
View article: Radiation-Induced Hypothyroidism After Radical Intensity Modulated Radiation Therapy for Oropharyngeal Carcinoma
Radiation-Induced Hypothyroidism After Radical Intensity Modulated Radiation Therapy for Oropharyngeal Carcinoma Open
Volume and Dmean of the TG are important predictors of clinical RHT and shall be integrated into normal tissue complication probability models for RHT. Dmean and thyroid volume should be considered during the IMRT plan optimization in OPC …
View article: Machine Learning Applications in Head and Neck Radiation Oncology: Lessons From Open-Source Radiomics Challenges
Machine Learning Applications in Head and Neck Radiation Oncology: Lessons From Open-Source Radiomics Challenges Open
Radiomics leverages existing image datasets to provide non-visible data extraction via image post-processing, with the aim of identifying prognostic, and predictive imaging features at a sub-region of interest level. However, the applicati…
View article: Epithelial-Mesenchymal Transition Markers in Breast Cancer and Pathological Responseafter Neoadjuvant Chemotherapy
Epithelial-Mesenchymal Transition Markers in Breast Cancer and Pathological Responseafter Neoadjuvant Chemotherapy Open
The association between pathologic complete response (pCR) following to neoadjuvant chemotherapy (NAC) and the improved survival in breast cancer has been previously reported. The aim of this study was is to explore the expression of sever…
View article: Matched computed tomography segmentation and demographic data for oropharyngeal cancer radiomics challenges
Matched computed tomography segmentation and demographic data for oropharyngeal cancer radiomics challenges Open
Cancers arising from the oropharynx have become increasingly more studied in the past few years, as they are now epidemic domestically. These tumors are treated with definitive (chemo)radiotherapy, and have local recurrence as a primary mo…
View article: Additional file 2: Table S2. of Long-term patient reported outcomes following radiation therapy for oropharyngeal cancer: cross-sectional assessment of a prospective symptom survey in patients â Ľ65Â years old
Additional file 2: Table S2. of Long-term patient reported outcomes following radiation therapy for oropharyngeal cancer: cross-sectional assessment of a prospective symptom survey in patients â Ľ65Â years old Open
Proportions of patients reporting severe (â Ľ7) rating for the 22 MDASI-HN symptom items by clinical subgroups of interest. (DOCX 17Â kb)
View article: MK-8776, a novel chk1 kinase inhibitor, radiosensitizes p53-defective human tumor cells
MK-8776, a novel chk1 kinase inhibitor, radiosensitizes p53-defective human tumor cells Open
Radiotherapy is commonly used to treat a variety of solid tumors but improvements in the therapeutic ratio are sorely needed. The aim of this study was to assess the Chk1 kinase inhibitor, MK-8776, for its ability to radiosensitize human t…