Crystal R. Noell
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View article: DNA tensiometer reveals catch-bond detachment kinetics of kinesin-1, -2 and -3
DNA tensiometer reveals catch-bond detachment kinetics of kinesin-1, -2 and -3 Open
Bidirectional cargo transport by kinesin and dynein is essential for cell viability and defects are linked to neurodegenerative diseases. Computational modeling suggests that the load-dependent off-rate is the strongest determinant of whic…
View article: Author response: DNA tensiometer reveals catch-bond detachment kinetics of kinesin-1, -2 and -3
Author response: DNA tensiometer reveals catch-bond detachment kinetics of kinesin-1, -2 and -3 Open
View article: DNA tensiometer reveals catch-bond detachment kinetics of kinesin-1, -2 and -3
DNA tensiometer reveals catch-bond detachment kinetics of kinesin-1, -2 and -3 Open
Bidirectional cargo transport by kinesin and dynein is essential for cell viability and defects are linked to neurodegenerative diseases. Computational modeling suggests that the load-dependent off-rate is the strongest determinant of whic…
View article: Role of Nesprin-2 and RanBP2 in BICD2-associated brain developmental disorders
Role of Nesprin-2 and RanBP2 in BICD2-associated brain developmental disorders Open
Bicaudal D2 (BICD2) is responsible for recruiting cytoplasmic dynein to diverse forms of subcellular cargo for their intracellular transport. Mutations in the human BICD2 gene have been found to cause an autosomal dominant form of spinal m…
View article: Adaptor Proteins for Opposing Motors Interact Simultaneously to Nuclear Pore Protein Nup358
Adaptor Proteins for Opposing Motors Interact Simultaneously to Nuclear Pore Protein Nup358 Open
View article: Coiled-Coil Registry Shifts in the F684I Mutant of Bicaudal Result in Cargo-Independent Activation of Dynein Motility
Coiled-Coil Registry Shifts in the F684I Mutant of Bicaudal Result in Cargo-Independent Activation of Dynein Motility Open
View article: Adapter Proteins for Opposing Motors Interact Simultaneously with Nuclear Pore Protein Nup358
Adapter Proteins for Opposing Motors Interact Simultaneously with Nuclear Pore Protein Nup358 Open
Nup358 is a protein subunit of the nuclear pore complex that recruits the opposing microtubule motors kinesin-1 and dynein [via the dynein adaptor Bicaudal D2 (BicD2)] to the nuclear envelope. This pathway is important for positioning of t…
View article: Role of Coiled-Coil Registry Shifts in the Activation of Human Bicaudal D2 for Dynein Recruitment upon Cargo Binding
Role of Coiled-Coil Registry Shifts in the Activation of Human Bicaudal D2 for Dynein Recruitment upon Cargo Binding Open
Dynein adaptors such as Bicaudal D2 (BicD2) recognize cargo for dynein-dependent transport, and cargo-bound adaptors are required to activate dynein for processive transport, but the mechanism of action is unknown. Here we report the X-ray…
View article: Role of coiled-coil registry shifts in activation of human Bicaudal D2 for dynein recruitment upon cargo-binding
Role of coiled-coil registry shifts in activation of human Bicaudal D2 for dynein recruitment upon cargo-binding Open
SUMMARY Dynein adaptors such as Bicaudal D2 (BicD2) recognize cargo for dynein-dependent transport. BicD2-dependent transport pathways are important for brain and muscle development. Cargo-bound adaptors are required to activate dynein for…
View article: Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an <em>In Vitro</em> Kinase Assay
Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an <em>In Vitro</em> Kinase Assay Open
Cyclin-dependent kinase 1 (Cdk1) is a master controller for the cell cycle in all eukaryotes and phosphorylates an estimated 8 - 13% of the proteome; however, the number of identified targets for Cdk1, particularly in human cells is still …