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View article: mRNA-LNP vaccine-induced CD8+ T cells protect mice from lethal SARS-CoV-2 infection in the absence of specific antibodies
mRNA-LNP vaccine-induced CD8+ T cells protect mice from lethal SARS-CoV-2 infection in the absence of specific antibodies Open
The role of CD8+ T cells in SARS-CoV-2 pathogenesis or mRNA-LNP vaccine-induced protection from lethal COVID-19 is unclear. Using mouse-adapted SARS-CoV-2 virus (MA30) in C57BL/6 mice, we show that CD8+ T cells are unnecessary for the intr…
A bipartite NLS motif mediates the nuclear import of Drosophila moesin Open
The ERM protein family, which consists of three closely related proteins in vertebrates, ezrin, radixin, and moesin (ERM), is an ancient and important group of cytoplasmic actin-binding and organizing proteins. With their FERM domain, ERMs…
View article: Expression and purification of the receptor‐binding domain of <scp>SARS‐CoV</scp>‐2 spike protein in mammalian cells for immunological assays
Expression and purification of the receptor‐binding domain of <span>SARS‐CoV</span>‐2 spike protein in mammalian cells for immunological assays Open
The receptor‐binding domain (RBD) of the spike glycoprotein of SARS‐CoV‐2 virus mediates the interaction with the host cell and is required for virus internalization. It is, therefore, the primary target of neutralizing antibodies. The rec…
Assessment of a quadrivalent nucleoside-modified mRNA vaccine that protects against group 2 influenza viruses Open
Combined vaccine formulations targeting not only hemagglutinin but also other influenza virus antigens could form the basis for a universal influenza virus vaccine that has the potential to elicit long-lasting, broadly cross-reactive immun…
Parallel import mechanisms ensure the robust nuclear localization of actin in Drosophila Open
Actin, as an ancient and fundamental protein, participates in various cytoplasmic as well as nuclear functions in eukaryotic cells. Based on its manifold tasks in the nucleus, it is a reasonable assumption that the nuclear presence of acti…
The nuclear activity of the actin‐binding Moesin protein is necessary for gene expression in <i>Drosophila</i> Open
Ezrin–Radixin–Moesin (ERM) proteins play an essential role in the cytoplasm by cross‐linking actin filaments with plasma membrane proteins. Research has identified the nuclear localization of ERMs, as well as the involvement of a single Dr…