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View article: Diffusion Tractography Biomarker for Epilepsy Severity in Children With Drug‐Resistant Epilepsy
Diffusion Tractography Biomarker for Epilepsy Severity in Children With Drug‐Resistant Epilepsy Open
Objective To develop a novel deep‐learning model of clinical DWI tractography that can accurately predict the general assessment of epilepsy severity (GASE) in pediatric drug‐resistant epilepsy (DRE) and test if it can screen diverse neuro…
View article: Newly diagnosed glioblastoma IDHwt patients treated with radiation, nivolumab, and BMS-986205
Newly diagnosed glioblastoma IDHwt patients treated with radiation, nivolumab, and BMS-986205 Open
This phase I trial evaluated the IDO1 enzyme inhibitor, BMS-986205, with radiation (RT) and nivolumab treatment in newly diagnosed patients with GBM IDHwt. Cohort A received RT + nivolumab with escalating BMS-986205 doses in MGMT unmethyla…
View article: Feasibility and Potential Diagnostic Value of Noncontrast Brain MRI in Nonsedated Children With Sturge-Weber Syndrome and Healthy Siblings
Feasibility and Potential Diagnostic Value of Noncontrast Brain MRI in Nonsedated Children With Sturge-Weber Syndrome and Healthy Siblings Open
Background Postcontrast magnetic resonance imaging (MRI), obtained under anesthesia, is often used to evaluate brain parenchymal and vascular abnormalities in young children, including those with Sturge-Weber syndrome. However, anesthesia …
View article: Quantification of enlarged deep medullary vein volumes in Sturge-Weber syndrome
Quantification of enlarged deep medullary vein volumes in Sturge-Weber syndrome Open
EDMVs were detected in the SWS-affected atrophic hemispheres reliably while avoiding calcified regions. The approach can be used to quantify enlarged deep cerebral veins in the human brain, which may provide a potential marker of cerebral …
View article: The First Human Application of an F-18-Labeled Tryptophan Analog for PET Imaging of Cancer
The First Human Application of an F-18-Labeled Tryptophan Analog for PET Imaging of Cancer Open
View article: The First Human Application of an F-18-labeled Tryptophan Analog for PET Imaging of Cancer
The First Human Application of an F-18-labeled Tryptophan Analog for PET Imaging of Cancer Open
Purpose. Preclinical studies showed the tryptophan analog PET radiotracer 1-(2- 18 F-fluoroethyl)-L-tryptophan ( 18 F-FETrp) to accumulate in various tumors, including gliomas, and being metabolized via the immunosuppressive kynurenine pat…
View article: Longitudinal imaging in Kleefstra syndrome—Brief report and literature review
Longitudinal imaging in Kleefstra syndrome—Brief report and literature review Open
Background Kleefstra syndrome (KS) is a rare genetic condition affecting the euchromatic histone methyltransferase 1 ( EHMT1 ) gene, typically presenting with developmental delay, generalized hypotonia, distinctive facial dysmorphisms, and…
View article: Automated radiosynthesis of 1‐(2‐[<sup>18</sup>F]fluoroethyl)‐L‐tryptophan ([<sup>18</sup>F]FETrp) for positron emission tomography (PET) imaging of cancer in humans
Automated radiosynthesis of 1‐(2‐[<sup>18</sup>F]fluoroethyl)‐L‐tryptophan ([<sup>18</sup>F]FETrp) for positron emission tomography (PET) imaging of cancer in humans Open
The radiotracer 1‐(2‐[ 18 F]fluoroethyl)‐L‐tryptophan (L‐[ 18 F]FETrp or [ 18 F]FETrp) is a substrate of indoleamine 2,3‐dioxygenase, the initial and key enzyme of the kynurenine pathway associated with tumoral immune resistance. In precli…
View article: Deep Venous Remodeling in Unilateral Sturge-Weber Syndrome: Robust Hemispheric Differences and Clinical Correlates
Deep Venous Remodeling in Unilateral Sturge-Weber Syndrome: Robust Hemispheric Differences and Clinical Correlates Open
View article: Multi-Scale Deep Learning of Clinically Acquired Multi-Modal MRI Improves the Localization of Seizure Onset Zone in Children With Drug-Resistant Epilepsy
Multi-Scale Deep Learning of Clinically Acquired Multi-Modal MRI Improves the Localization of Seizure Onset Zone in Children With Drug-Resistant Epilepsy Open
The present study investigates the effectiveness of a deep learning neural network for non-invasively localizing the seizure onset zone (SOZ) using multi-modal MRI data that are clinically acquired from children with drug-resistant epileps…
View article: Diffusion tractography predicts propagated high‐frequency activity during epileptic spasms
Diffusion tractography predicts propagated high‐frequency activity during epileptic spasms Open
Objective To determine the structural networks that constrain propagation of ictal oscillations during epileptic spasm events, and compare the observed propagation patterns across patients with successful or unsuccessful surgical outcomes.…
View article: Prostate-Specific Membrane Antigen as Target for Neuroimaging of Central Nervous System Tumors
Prostate-Specific Membrane Antigen as Target for Neuroimaging of Central Nervous System Tumors Open
Introduction. Positron emission tomography (PET) imaging with prostate-specific membrane antigen- (PSMA-) binding tracers has been found incidentally to demonstrate uptake in CNS tumors. Following the encouraging findings of several such c…
View article: TAMI-15. PROSTATE SPECIFIC MEMBRANE ANTIGEN EXPRESSION IN GLIOBLASTOMA TUMOR AND ENDOTHELIAL CELLS
TAMI-15. PROSTATE SPECIFIC MEMBRANE ANTIGEN EXPRESSION IN GLIOBLASTOMA TUMOR AND ENDOTHELIAL CELLS Open
INTRODUCTION Prostate specific membrane antigen (PSMA) has emerged in recent years as a potential target for PET imaging of CNS tumors. Originally studied for imaging in prostate cancer, it was incidentally found to have selective uptake i…
View article: Another strong argument for the early, aggressive management of seizures to optimize neuro-cognitive outcome in Sturge-Weber syndrome
Another strong argument for the early, aggressive management of seizures to optimize neuro-cognitive outcome in Sturge-Weber syndrome Open
View article: Consensus Statement for the Management and Treatment of Sturge-Weber Syndrome: Neurology, Neuroimaging, and Ophthalmology Recommendations
Consensus Statement for the Management and Treatment of Sturge-Weber Syndrome: Neurology, Neuroimaging, and Ophthalmology Recommendations Open
Children with a high-risk facial port-wine birthmark (PWB) should be referred to a pediatric neurologist and a pediatric ophthalmologist for baseline evaluation and periodic follow-up. In newborns and infants with a high-risk PWB and no hi…
View article: Deep reasoning neural network analysis to predict language deficits from psychometry‐driven DWI connectome of young children with persistent language concerns
Deep reasoning neural network analysis to predict language deficits from psychometry‐driven DWI connectome of young children with persistent language concerns Open
This study investigated whether current state‐of‐the‐art deep reasoning network analysis on psychometry‐driven diffusion tractography connectome can accurately predict expressive and receptive language scores in a cohort of young children …
View article: Prediction of baseline expressive and receptive language function in children with focal epilepsy using diffusion tractography-based deep learning network
Prediction of baseline expressive and receptive language function in children with focal epilepsy using diffusion tractography-based deep learning network Open
View article: Multicenter Research Data of Epilepsy Management in Patients With Sturge-Weber Syndrome
Multicenter Research Data of Epilepsy Management in Patients With Sturge-Weber Syndrome Open
View article: Comparison of Amino Acid PET to Advanced and Emerging MRI Techniques for Neurooncology Imaging: A Systematic Review of the Recent Studies
Comparison of Amino Acid PET to Advanced and Emerging MRI Techniques for Neurooncology Imaging: A Systematic Review of the Recent Studies Open
Introduction. Standard neuroimaging protocols for brain tumors have well-known limitations. The clinical use of additional modalities including amino acid PET (aaPET) and advanced MRI (aMRI) techniques (including DWI, PWI, and MRS) is emer…
View article: Molecular Imaging of Brain Tumor-Associated Epilepsy
Molecular Imaging of Brain Tumor-Associated Epilepsy Open
Epilepsy is a common clinical manifestation and a source of significant morbidity in patients with brain tumors. Neuroimaging has a pivotal role in neuro-oncology practice, including tumor detection, differentiation, grading, treatment gui…
View article: Deep Relational Reasoning for the Prediction of Language Impairment and Postoperative Seizure Outcome Using Preoperative DWI Connectome Data of Children With Focal Epilepsy
Deep Relational Reasoning for the Prediction of Language Impairment and Postoperative Seizure Outcome Using Preoperative DWI Connectome Data of Children With Focal Epilepsy Open
Prolonged seizures in children with focal epilepsy (FE) may impair language functions and often reoccur after surgical intervention. This study is aimed at developing a novel deep relational reasoning network to investigate whether convent…
View article: Decreased Expression of ZNF554 in Gliomas is Associated with the Activation of Tumor Pathways and Shorter Patient Survival
Decreased Expression of ZNF554 in Gliomas is Associated with the Activation of Tumor Pathways and Shorter Patient Survival Open
Zinc finger protein 554 (ZNF554), a member of the Krüppel-associated box domain zinc finger protein subfamily, is predominantly expressed in the brain and placenta in humans. Recently, we unveiled that ZNF554 regulates trophoblast invasion…
View article: Depression and tryptophan metabolism in patients with primary brain tumors: Clinical and molecular imaging correlates
Depression and tryptophan metabolism in patients with primary brain tumors: Clinical and molecular imaging correlates Open
View article: Multimodal neuroimaging of gliomatosis cerebri: a case series of four patients
Multimodal neuroimaging of gliomatosis cerebri: a case series of four patients Open
In the latest World Health Organization classification of brain tumors, gliomatosis cerebri has been redefined to varying subsets of diffuse gliomas; however, the term is still used to describe gliomas with infiltrative growth into three o…
View article: Novel Deep Learning Network Analysis of Electrical Stimulation Mapping-Driven Diffusion MRI Tractography to Improve Preoperative Evaluation of Pediatric Epilepsy
Novel Deep Learning Network Analysis of Electrical Stimulation Mapping-Driven Diffusion MRI Tractography to Improve Preoperative Evaluation of Pediatric Epilepsy Open
OBJECTIVE: To investigate the clinical utility of deep convolutional neural network (DCNN) tract classification as a new imaging tool in the preoperative evaluation of children with focal epilepsy (FE). METHODS: A DCNN tract classification…
View article: Toward a better understanding of stroke-like episodes in Sturge-Weber syndrome
Toward a better understanding of stroke-like episodes in Sturge-Weber syndrome Open
View article: Feasibility of Multimodal MRI-Based Deep Learning Prediction of High Amino Acid Uptake Regions and Survival in Patients With Glioblastoma
Feasibility of Multimodal MRI-Based Deep Learning Prediction of High Amino Acid Uptake Regions and Survival in Patients With Glioblastoma Open
Purpose: Amino acid PET has shown high accuracy for the diagnosis and prognostication of malignant gliomas, however, this imaging modality is not widely available in clinical practice. This study explores a novel end-to-end deep lea…
View article: Quantitative analysis of intracranial electrocorticography signals using the concept of statistical parametric mapping
Quantitative analysis of intracranial electrocorticography signals using the concept of statistical parametric mapping Open
View article: Fluorine-18-Labeled PET Radiotracers for Imaging Tryptophan Uptake and Metabolism: a Systematic Review
Fluorine-18-Labeled PET Radiotracers for Imaging Tryptophan Uptake and Metabolism: a Systematic Review Open
View article: P14.69 Evaluation of electric field intensity delivered by Tumor-Treating Fields therapy to PET-defined metabolic volumes in recurrent glioblastomas
P14.69 Evaluation of electric field intensity delivered by Tumor-Treating Fields therapy to PET-defined metabolic volumes in recurrent glioblastomas Open
BACKGROUND Tumor-Treating Fields (TTFields) therapy is a clinical treatment option for patients with newly-diagnosed and recurrent glioblastomas. Electric field intensities (EFIs) delivered to the tumor mass may affect treatment responses.…