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View article: Human Brain Cell‐Type‐Specific Aging Clocks Based on Single‐Nuclei Transcriptomics
Human Brain Cell‐Type‐Specific Aging Clocks Based on Single‐Nuclei Transcriptomics Open
Aging is the primary risk factor for most neurodegenerative diseases, yet the cell‐type‐specific progression of brain aging remains poorly understood. Here, human cell‐type‐specific transcriptomic aging clocks are developed using high‐qual…
View article: Improving face age prediction by using multiple-angle photos
Improving face age prediction by using multiple-angle photos Open
Face photo-based age provides a cost-effective and readily accessible tool for biological age studies. However, face photo age models were usually trained on a single front-view photo per subject. Here, we hypothesized that face photo-base…
View article: CpGeneAge: multi-omics aging clocks associated with Nf-κB signaling pathway in aging
CpGeneAge: multi-omics aging clocks associated with Nf-κB signaling pathway in aging Open
Aging clocks have emerged as the primary tools for measuring biological aging and have been developed for a wide range of single-omic measurements. Epigenetic aging clocks showed high accuracy in age prediction, however, their biological i…
View article: Organ Specificity and Commonality of Epigenetic Aging in Low‐ and High‐Running Capacity Rats
Organ Specificity and Commonality of Epigenetic Aging in Low‐ and High‐Running Capacity Rats Open
Epigenetic drift, which is gradual age‐related changes in DNA methylation patterns, plays a significant role in aging and age‐related diseases. However, the relationship between exercise, epigenetics, and aging, and the molecular mechanism…
View article: Face photo-based age acceleration predicts all-cause mortality and differs among occupations
Face photo-based age acceleration predicts all-cause mortality and differs among occupations Open
While scientists argue what aging is and what drives aging, it is widely accepted that our face changes drastically with age and that mortality increases in late life. We hypothesize that people of the same age can be biologically older th…
View article: Associations of epigenetic aging and COVID- 19: A 3-year longitudinal study
Associations of epigenetic aging and COVID- 19: A 3-year longitudinal study Open
Aging and COVID- 19 are known to influence DNA methylation, potentially affecting the rate of aging and the risk of disease. The physiological functions of 54 volunteers—including maximal oxygen uptake (VO₂ max), grip strength, and vertica…
View article: Innovation in Suicidology: Artificial Intelligence-Based Risk Assessment
Innovation in Suicidology: Artificial Intelligence-Based Risk Assessment Open
Introduction The use of artificial intelligence (AI) in suicide risk assessment is gaining prominence as AI algorithms are capable of processing and analyzing large volumes of data quickly. Suicide risk assessments are traditionally carrie…
View article: Human brain cell-type-specific aging clocks based on single-nuclei transcriptomics
Human brain cell-type-specific aging clocks based on single-nuclei transcriptomics Open
Aging is the primary risk factor for most neurodegenerative diseases, yet the cell-type-specific progression of brain aging remains poorly understood. Here, we developed human cell-type-specific transcriptomic aging clocks using high-quali…
View article: Machine learning prediction of breast cancer local recurrence localization, and distant metastasis after local recurrences
Machine learning prediction of breast cancer local recurrence localization, and distant metastasis after local recurrences Open
Local recurrences (LR) can occur within residual breast tissue, chest wall, skin, or newly formed scar tissue. Artificial intelligence (AI) technologies can extract a wide range of tumor features from large datasets helping in oncological …
View article: Disagreement on foundational principles of biological aging
Disagreement on foundational principles of biological aging Open
To gain insight into how researchers of aging perceive the process they study, we conducted a survey among experts in the field. While highlighting some common features of aging, the survey exposed broad disagreement on the foundational is…
View article: Slowed epigenetic aging in Olympic champions compared to non-champions
Slowed epigenetic aging in Olympic champions compared to non-champions Open
The lifestyle patterns of top athletes are highly disciplined, featuring strict exercise regimens, nutrition plans, and mental preparation, often beginning at a young age. Recently, it was shown that physically active individuals exhibit s…
View article: Profiling the transcriptomic age of single-cells in humans
Profiling the transcriptomic age of single-cells in humans Open
Although aging clocks predicting the age of individual organisms have been extensively studied, the age of individual cells remained largely unexplored. Most recently single-cell omics clocks were developed for the mouse, however, extensiv…
View article: Organ specificity and commonality of epigenetic aging in low- and high-running capacity rats
Organ specificity and commonality of epigenetic aging in low- and high-running capacity rats Open
Background Epigenetic drift, which are gradual age-related changes in DNA methylation patterns, plays a significant role in aging and age-related diseases. However, the relationship between exercise, epigenetics, and aging and the molecula…
View article: Alterations of the gut microbiome are associated with epigenetic age acceleration and physical fitness
Alterations of the gut microbiome are associated with epigenetic age acceleration and physical fitness Open
Epigenetic clocks can measure aging and predict the incidence of diseases and mortality. Higher levels of physical fitness are associated with a slower aging process and a healthier lifespan. Microbiome alterations occur in various disease…
View article: Blood Test–Based Age Acceleration Is Inversely Associated with High-Volume Sports Activity
Blood Test–Based Age Acceleration Is Inversely Associated with High-Volume Sports Activity Open
Purpose We develop blood test–based aging clocks and examine how these clocks reflect high-volume sports activity. Methods We use blood tests and body metrics data of 421 Hungarian athletes and 283 age-matched controls (mean age, 24.1 and …
View article: Intersection clock reveals a rejuvenation event during human embryogenesis
Intersection clock reveals a rejuvenation event during human embryogenesis Open
Recent research revealed a rejuvenation event during early development of mice. Here, by examining epigenetic age dynamics of human embryogenesis, we tested whether a similar event exists in humans. For this purpose, we developed an epigen…
View article: Alterations of the gut microbiome are associated with epigenetic age acceleration and physical fitness
Alterations of the gut microbiome are associated with epigenetic age acceleration and physical fitness Open
Epigenetic clocks can measure aging and predict the incidence of diseases and mortality. Higher levels of physical fitness are associated with a slower aging process and a healthier lifespan. Microbiome alterations occur in various disease…
View article: Autonomous AI Agents Discover Aging Interventions from Millions of Molecular Profiles
Autonomous AI Agents Discover Aging Interventions from Millions of Molecular Profiles Open
Decades of publicly available molecular studies have generated millions of samples testing diverse interventions, yet these datasets were rarely analyzed for their effects on aging. Aging clocks now enable biological age estimation and lif…
View article: EPIGENETIC AGING OF THE DEMOGRAPHICALLY NONAGING NAKED MOLE RAT
EPIGENETIC AGING OF THE DEMOGRAPHICALLY NONAGING NAKED MOLE RAT Open
The naked mole-rat (NMR) is an exceptionally long-lived rodent that shows no increase of mortality with age, defining it as a demographically non-aging mammal. Here, we perform bisulfite sequencing of the blood of>100 NMRs, assessing>…
View article: Biological age is increased by stress and restored upon recovery
Biological age is increased by stress and restored upon recovery Open
Aging is classically conceptualized as an ever-increasing trajectory of damage accumulation and loss of function, leading to increases in morbidity and mortality. However, recent in vitro studies have raised the possibility of age reversal…
View article: Deterioration of the human transcriptome with age due to increasing intron retention and spurious splicing
Deterioration of the human transcriptome with age due to increasing intron retention and spurious splicing Open
Adult aging is characterized by a progressive deterioration of biological functions at physiological, cellular and molecular levels, but its damaging effects on the transcriptome are not well characterized. Here, by analyzing splicing patt…
View article: Spatial Variability of Soil Properties and Its Effect on Maize Yields within Field—A Case Study in Hungary
Spatial Variability of Soil Properties and Its Effect on Maize Yields within Field—A Case Study in Hungary Open
To better understand the potential of soils, understanding how soil properties vary over time and in-field is essential to optimize the cultivation and site-specific technologies in crop production. This article aimed at determining the wi…
View article: Emerging rejuvenation strategies—Reducing the biological age
Emerging rejuvenation strategies—Reducing the biological age Open
Several interventions have recently emerged that were proposed to reverse rather than just attenuate aging, but the criteria for what it takes to achieve rejuvenation remain controversial. Distinguishing potential rejuvenation therapies fr…