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View article: Progressing future osteoarthritis treatment toward precision medicine: integrating regenerative medicine, gene therapy and circadian biology
Progressing future osteoarthritis treatment toward precision medicine: integrating regenerative medicine, gene therapy and circadian biology Open
Osteoarthritis (OA) is marked by cartilage degradation, inflammation and varied pain. Traditional treatments such as nonsteroidal anti-inflammatory drugs primarily offer symptom relief without halting disease progression. Advances in regen…
View article: Podocalyxin and ciliary neurotrophic factor receptor are novel components of the surfaceome of chondrogenic cells
Podocalyxin and ciliary neurotrophic factor receptor are novel components of the surfaceome of chondrogenic cells Open
Background Osteoarthritis is a degenerative joint disease characterized by progressive loss of articular cartilage and limited capacity for intrinsic repair. A major barrier to developing effective regenerative strategies is the incomplete…
View article: The Inflammasome-miR Axis in Alzheimer’s Disease and Chronic Pain: Molecular Mechanisms and Therapeutic Opportunities
The Inflammasome-miR Axis in Alzheimer’s Disease and Chronic Pain: Molecular Mechanisms and Therapeutic Opportunities Open
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, synaptic dysfunction, and chronic neuroinflammation. Mounting evidence suggests that inflammasome activation plays a pivotal role in t…
View article: Hypoxic Conditions Modulate Chondrogenesis through the Circadian Clock: The Role of Hypoxia-Inducible Factor-1α
Hypoxic Conditions Modulate Chondrogenesis through the Circadian Clock: The Role of Hypoxia-Inducible Factor-1α Open
Hypoxia-inducible factor-1 (HIF-1) is a heterodimer transcription factor composed of an alpha and a beta subunit. HIF-1α is a master regulator of cellular response to hypoxia by activating the transcription of genes that facilitate metabol…
View article: Isolation and Culturing of Primary Murine Chondroprogenitor Cells: A Mammalian Model of Chondrogenesis
Isolation and Culturing of Primary Murine Chondroprogenitor Cells: A Mammalian Model of Chondrogenesis Open
Embryonic limb bud‐derived micromass cultures are valuable tools for investigating cartilage development, tissue engineering, and therapeutic strategies for cartilage‐related disorders. This collection of fine‐tuned protocols used in our l…
View article: Ion Channels As Emerging Metabolic Regulators and Therapeutic Targets in Osteoarthritis: Nav1.7 As a Recent Exemplar
Ion Channels As Emerging Metabolic Regulators and Therapeutic Targets in Osteoarthritis: Nav1.7 As a Recent Exemplar Open
Peer reviewed
View article: Isolation and Micromass Culturing of Primary Chicken Chondroprogenitor Cells for Cartilage Regeneration
Isolation and Micromass Culturing of Primary Chicken Chondroprogenitor Cells for Cartilage Regeneration Open
Much of the skeletal system develops by endochondral ossification, a process that takes place in early fetal life. This makes the early stages of chondrogenesis, i.e., when chondroprogenitor mesenchymal cells differentiate to chondroblasts…
View article: Combining biomechanical stimulation and chronobiology: a novel approach for augmented chondrogenesis?
Combining biomechanical stimulation and chronobiology: a novel approach for augmented chondrogenesis? Open
The unique structure and composition of articular cartilage is critical for its physiological function. However, this architecture may get disrupted by degeneration or trauma. Due to the low intrinsic regeneration properties of the tissue,…
View article: Ca2+-Activated K+ Channels in Progenitor Cells of Musculoskeletal Tissues: A Narrative Review
Ca2+-Activated K+ Channels in Progenitor Cells of Musculoskeletal Tissues: A Narrative Review Open
Musculoskeletal disorders represent one of the main causes of disability worldwide, and their prevalence is predicted to increase in the coming decades. Stem cell therapy may be a promising option for the treatment of some of the musculosk…
View article: The clusterin connectome: Emerging players in chondrocyte biology and putative exploratory biomarkers of osteoarthritis
The clusterin connectome: Emerging players in chondrocyte biology and putative exploratory biomarkers of osteoarthritis Open
Introduction Clusterin is a moonlighting protein that has many functions. It is a multifunctional holdase chaperone glycoprotein that is present intracellularly and extracellularly in almost all bodily fluids. Clusterin is involved in lipi…
View article: The temporal transcriptomic signature of cartilage formation
The temporal transcriptomic signature of cartilage formation Open
Chondrogenesis is a multistep process, in which cartilage progenitor cells generate a tissue with distinct structural and functional properties. Although several approaches to cartilage regeneration rely on the differentiation of implanted…
View article: Isolation of High‐Quality Total RNA from Small Animal Articular Cartilage for Next‐Generation Sequencing
Isolation of High‐Quality Total RNA from Small Animal Articular Cartilage for Next‐Generation Sequencing Open
Articular cartilage is characterized by a low density of chondrocytes surrounded by an abundant extracellular matrix (ECM) consisting of a dense mixture of collagens, proteoglycans, and glycosaminoglycans. Due to its low cellularity and hi…
View article: Cyclic uniaxial mechanical load enhances chondrogenesis through entraining the molecular circadian clock
Cyclic uniaxial mechanical load enhances chondrogenesis through entraining the molecular circadian clock Open
The biomechanical environment plays a key role in regulating cartilage formation, but the current understanding of mechanotransduction pathways in chondrogenic cells is incomplete. Among the combination of external factors that control cho…
View article: The temporal transcriptomic signature of cartilage formation
The temporal transcriptomic signature of cartilage formation Open
Chondrogenesis is a multistep process, in which cartilage progenitor cells generate a tissue with distinct structural and functional properties. Although several approaches to cartilage regeneration rely on the differentiation of implanted…
View article: Structural and magnetic characterisation of a biocompatible magnetic nanoparticle assembly
Structural and magnetic characterisation of a biocompatible magnetic nanoparticle assembly Open
Magnetic nanoparticles have several promising biomedical applications. One example is the magnetic nanoparticle-based hyperthermia, where the magnetic nanoparticles absorbed by the tumor cells are subjected to alternating magnetic field to…
View article: Cyclic uniaxial mechanical load enhances chondrogenesis through entraining the molecular circadian clock
Cyclic uniaxial mechanical load enhances chondrogenesis through entraining the molecular circadian clock Open
The biomechanical environment plays a key role in regulating cartilage formation, but current understanding of mechanotransduction pathways in chondrogenic cells is incomplete. Amongst the combination of external factors that control chond…
View article: Analysis of Gene Expression Patterns of Epigenetic Enzymes Dnmt3a, Tet1 and Ogt in Murine Chondrogenic Models
Analysis of Gene Expression Patterns of Epigenetic Enzymes Dnmt3a, Tet1 and Ogt in Murine Chondrogenic Models Open
We investigated the gene expression pattern of selected enzymes involved in DNA methylation and the effects of the DNA methylation inhibitor 5-azacytidine during in vitro and in vivo cartilage formation. Based on the data of a PCR array pe…
View article: Dielectrophoresis as a Tool to Reveal the Potential Role of Ion Channels and Early Electrophysiological Changes in Osteoarthritis
Dielectrophoresis as a Tool to Reveal the Potential Role of Ion Channels and Early Electrophysiological Changes in Osteoarthritis Open
Diseases such as osteoarthritis (OA) are commonly characterized at the molecular scale by gene expression and subsequent protein production; likewise, the effects of pharmaceutical interventions are typically characterized by the effects o…
View article: Transcriptome‐based screening of ion channels and transporters in a migratory chondroprogenitor cell line isolated from late‐stage osteoarthritic cartilage
Transcriptome‐based screening of ion channels and transporters in a migratory chondroprogenitor cell line isolated from late‐stage osteoarthritic cartilage Open
Chondrogenic progenitor cells (CPCs) may be used as an alternative source of cells with potentially superior chondrogenic potential compared to mesenchymal stem cells (MSCs), and could be exploited for future regenerative therapies targeti…
View article: Modulation of DNA Methylation Influences Cartilage Formation in Murine Chondrogenic Models
Modulation of DNA Methylation Influences Cartilage Formation in Murine Chondrogenic Models Open
The aim of this study was to investigate the role of DNA methylation in the regulation of in vitro and in vivo cartilage formation. Based on the data of an RNA chip-assay performed on chondrifying BMP2-overexpressing C3H10T1/2 cells, the r…
View article: Transcriptome-based screening of ion channels and transporters in a migratory chondroprogenitor cell line isolated from late-stage osteoarthritic cartilage
Transcriptome-based screening of ion channels and transporters in a migratory chondroprogenitor cell line isolated from late-stage osteoarthritic cartilage Open
Chondrogenic progenitor cells (CPCs) may be used as an alternative source of cells with potentially superior chondrogenic potential compared to mesenchymal stem cells (MSCs), and could be exploited for future regenerative therapies targeti…
View article: Clusterin secretion is attenuated by the proinflammatory cytokines interleukin‐1β and tumor necrosis factor‐α in models of cartilage degradation
Clusterin secretion is attenuated by the proinflammatory cytokines interleukin‐1β and tumor necrosis factor‐α in models of cartilage degradation Open
The protein clusterin has been implicated in the molecular alterations that occur in articular cartilage during osteoarthritis (OA). Clusterin exists in two isoforms with opposing functions, and their roles in cartilage have not been explo…
View article: Clusterin secretion is attenuated by pro-inflammatory cytokines in culture models of cartilage degradation
Clusterin secretion is attenuated by pro-inflammatory cytokines in culture models of cartilage degradation Open
Proteomic studies have implicated clusterin as a potential biomarker of osteoarthritis (OA). However, there are two isoforms of clusterin with opposing functions, and their roles in OA have not previously been clarified. The secreted form …