Csenge Koppány
YOU?
Author Swipe
View article: Revisiting the Role of the Leucine Plug/Valve in the Human ABCG2 Multidrug Transporter
Revisiting the Role of the Leucine Plug/Valve in the Human ABCG2 Multidrug Transporter Open
In the human ABCG2 (ATP Binding Casette transporter G2/BCRP/MXR) multidrug transporter, a so-called “leucin plug/valve” (a.a. L554/L555) has been suggested to facilitate substrate exit and the coupling of drug transport to ATPase activity.…
View article: Revisiting the Role of the Leucine Plug/Valve in the Human ABCG2 Multidrug Transporter
Revisiting the Role of the Leucine Plug/Valve in the Human ABCG2 Multidrug Transporter Open
In the human ABCG2 multidrug transporter a so called “leucin plug/valve” (aa. L554/L555) has been suggested to determine substrate exit and coupling of drug transport to ATPase activity. In this work we have analyzed the effect…
View article: Nanomolar Inhibitors of Glycogen Phosphorylase Based on β-<scp>d</scp>-Glucosaminyl Heterocycles: A Combined Synthetic, Enzyme Kinetic, and Protein Crystallography Study
Nanomolar Inhibitors of Glycogen Phosphorylase Based on β-<span>d</span>-Glucosaminyl Heterocycles: A Combined Synthetic, Enzyme Kinetic, and Protein Crystallography Study Open
Aryl substituted 1-(β-d-glucosaminyl)-1,2,3-triazoles as well as C-β-d-glucosaminyl 1,2,4-triazoles and imidazoles were synthesized and tested as inhibitors against muscle and liver isoforms of glycogen phosphorylase (GP). While the N-β-d-…