Yongmei Liu
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View article: Association of Epigenetic Age Acceleration and Mitochondrial <scp>DNA</scp> ‐Based Aging Metrics Provides Insights Into Mechanisms of Aging‐Related Diseases
Association of Epigenetic Age Acceleration and Mitochondrial <span>DNA</span> ‐Based Aging Metrics Provides Insights Into Mechanisms of Aging‐Related Diseases Open
Investigating the interplay between mitochondrial DNA (mtDNA) variations and epigenetic aging metrics may elucidate biological mechanisms associated with age‐related diseases. We estimated epigenetic age acceleration (EAA) metrics from DNA…
View article: Robust Mixed Model Association Test for Gene-Environment Interactions
Robust Mixed Model Association Test for Gene-Environment Interactions Open
Linear mixed models (LMMs) are widely used in gene-environment interaction (GEI) studies to account for population structure and relatedness. However, genome-wide GEI tests using LMMs are computationally intensive, and model-based tests ca…
View article: Integrating genetic and transcriptomic data to identify genes underlying obesity risk loci
Integrating genetic and transcriptomic data to identify genes underlying obesity risk loci Open
View article: Genome-wide association study provides novel insight into the genetic architecture of severe obesity
Genome-wide association study provides novel insight into the genetic architecture of severe obesity Open
Severe obesity (SevO) is a primary driver of cardiovascular diseases (CVD), cardiometabolic diseases (CMD) and several cancers, with a disproportionate impact on marginalized populations. SevO is an understudied global health disease, limi…
View article: Genome-wide association study provides novel insight into the genetic architecture of severe obesity
Genome-wide association study provides novel insight into the genetic architecture of severe obesity Open
Severe obesity (SevO) is a primary driver of cardiovascular diseases (CVD), cardiometabolic diseases (CMD) and several cancers, with a disproportionate impact on marginalized populations. SevO is an understudied global health disease, limi…
View article: Racial and ethnic differences in epigenetic aging: The National Health and Nutrition Examination Survey, 1999–2002
Racial and ethnic differences in epigenetic aging: The National Health and Nutrition Examination Survey, 1999–2002 Open
Background Accelerated biological aging due to differences in socially patterned exposures has been proposed as a mechanism underlying racial and ethnic disparities in morbidity and mortality. Research exploring this hypothesis has been li…
View article: Learning Gaussian graphical models from correlated data
Learning Gaussian graphical models from correlated data Open
Gaussian Graphical Models (GGMs) are a type of network modeling that uses partial correlation rather than correlation for representing complex relationships among multiple variables. The advantage of using partial correlation is to show th…
View article: Multi-ancestry genome-wide association analyses incorporating SNP-by-psychosocial interactions identify novel loci for serum lipids
Multi-ancestry genome-wide association analyses incorporating SNP-by-psychosocial interactions identify novel loci for serum lipids Open
View article: Omic Risk Scores are Associated with COPD-related Traits Across Three Cohorts
Omic Risk Scores are Associated with COPD-related Traits Across Three Cohorts Open
Background Chronic obstructive pulmonary disease (COPD) exhibits marked heterogeneity in lung function decline, mortality, exacerbations, and other disease-related outcomes. Omic risk scores (ORS) estimate the cumulative contribution of om…
View article: Lipoprotein(a) and Heart Failure Among Black and White Participants in Atherosclerosis Risk in Communities Study, Framingham Offspring Study, and Multi‐Ethnic Study of Atherosclerosis: The Pooling Project
Lipoprotein(a) and Heart Failure Among Black and White Participants in Atherosclerosis Risk in Communities Study, Framingham Offspring Study, and Multi‐Ethnic Study of Atherosclerosis: The Pooling Project Open
Background This study investigated Lp(a) (lipoprotein(a)) levels with heart failure (HF) incidence overall and ejection fraction (EF) subtypes among Black and White participants in a pooled analysis of MESA (Multi‐Ethnic Study of Atheroscl…
View article: Epigenetic mechanisms underlying variation of IL-6, a well-established inflammation biomarker and risk factor for cardiovascular disease
Epigenetic mechanisms underlying variation of IL-6, a well-established inflammation biomarker and risk factor for cardiovascular disease Open
View article: Multi-ancestry whole genome sequencing analysis of lean body mass
Multi-ancestry whole genome sequencing analysis of lean body mass Open
Our comprehensive analysis, encompassing a large-scale WGS meta-analysis and functional investigations, reveals novel genomic loci and genes associated with lean mass traits, shedding new insights into pathways influencing muscle metabolis…
View article: Lipoprotein(a) and Risk of Incident Atherosclerotic Cardiovascular Disease: Impact of High-Sensitivity C-Reactive Protein and Risk Variability Among Human Clinical Subgroups
Lipoprotein(a) and Risk of Incident Atherosclerotic Cardiovascular Disease: Impact of High-Sensitivity C-Reactive Protein and Risk Variability Among Human Clinical Subgroups Open
Background/Objectives: Elevated lipoprotein(a) [Lp(a)] is associated with increased incidence of atherosclerotic cardiovascular disease (ASCVD). We aimed to assess the utility of Lp(a) as an ASCVD risk-enhancing factor, as recommended by t…
View article: Diabetes Mellitus Risk Prediction in the Framingham Offspring Study and Large Population Analysis
Diabetes Mellitus Risk Prediction in the Framingham Offspring Study and Large Population Analysis Open
Background: Diabetes mellitus is a major cause of death and a significant risk factor for cardiovascular disease, kidney failure, neuropathy, and retinopathy. Our objectives were to develop a diabetes risk model and apply it to a large pop…
View article: Heterogeneous effects of genetic variants and traits associated with fasting insulin on cardiometabolic outcomes
Heterogeneous effects of genetic variants and traits associated with fasting insulin on cardiometabolic outcomes Open
Elevated fasting insulin levels (FI), indicative of altered insulin secretion and sensitivity, may precede type 2 diabetes (T2D) and cardiovascular disease onset. In this study, we group FI-associated genetic variants based on their geneti…
View article: Cross-cohort analysis of expression and splicing quantitative trait loci in TOPMed
Cross-cohort analysis of expression and splicing quantitative trait loci in TOPMed Open
Most genetic variants associated with complex traits and diseases occur in non-coding genomic regions and are hypothesized to regulate gene expression. To understand the genetics underlying gene expression variability, we characterize 14,3…
View article: A statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies
A statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies Open
View article: Epigenome-wide association study of perceived discrimination in the Multi-Ethnic Study of Atherosclerosis (MESA)
Epigenome-wide association study of perceived discrimination in the Multi-Ethnic Study of Atherosclerosis (MESA) Open
Perceived discrimination, recognized as a chronic psychosocial stressor, has adverse consequences on health. DNA methylation (DNAm) may be a potential mechanism by which stressors get embedded into the human body at the molecular level and…
View article: Outcome-Driven Deep Clustering with Applications in Clinical Research
Outcome-Driven Deep Clustering with Applications in Clinical Research Open
View article: MultiLogicNMR(er): A Benchmark and Neural-Symbolic Framework for Non-monotonic Reasoning with Multiple Extensions
MultiLogicNMR(er): A Benchmark and Neural-Symbolic Framework for Non-monotonic Reasoning with Multiple Extensions Open
View article: Subclinical Vascular Disorders in Relation to Cognitive Decline and Impairment: The Multi‐Ethnic Study of Atherosclerosis
Subclinical Vascular Disorders in Relation to Cognitive Decline and Impairment: The Multi‐Ethnic Study of Atherosclerosis Open
Background Vascular disorders are proposed as modifiable risk factors for dementia; yet, physiologic mechanisms connecting vascular disorders to cognitive impairment remain unknown. We examined subclinical cardiovascular measures to determ…
View article: miR-450b-5p promotes development of endometriosis by inhibiting the GABPA/HOXD10 axis
miR-450b-5p promotes development of endometriosis by inhibiting the GABPA/HOXD10 axis Open
View article: Proteome-wide association studies for blood lipids and comparison with transcriptome-wide association studies
Proteome-wide association studies for blood lipids and comparison with transcriptome-wide association studies Open
View article: Machine learning‐based clustering identifies obesity subgroups with differential multi‐omics profiles and metabolic patterns
Machine learning‐based clustering identifies obesity subgroups with differential multi‐omics profiles and metabolic patterns Open
Objective Individuals living with obesity are differentially susceptible to cardiometabolic diseases. We hypothesized that an integrative multi‐omics approach might improve identification of subgroups of individuals with obesity who have d…
View article: Whole-genome sequencing in 333,100 individuals reveals rare non-coding single variant and aggregate associations with height
Whole-genome sequencing in 333,100 individuals reveals rare non-coding single variant and aggregate associations with height Open
View article: Integrating Genetic and Transcriptomic Data to Identify Genes Underlying Obesity Risk Loci
Integrating Genetic and Transcriptomic Data to Identify Genes Underlying Obesity Risk Loci Open
Genome-wide association studies (GWAS) have identified numerous body mass index (BMI) loci. However, most underlying mechanisms from risk locus to BMI remain unknown. Leveraging omics data through integrative analyses could provide more co…
View article: Vascular function and skeletal fragility: a study of tonometry, brachial hemodynamics, and bone microarchitecture
Vascular function and skeletal fragility: a study of tonometry, brachial hemodynamics, and bone microarchitecture Open
Osteoporosis and cardiovascular disease frequently occur together in older adults; however, a causal relationship between these 2 common conditions has not been established. By the time clinical cardiovascular disease develops, it is often…
View article: Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People With Type 2 Diabetes
Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People With Type 2 Diabetes Open
OBJECTIVE To identify genetic risk factors for incident cardiovascular disease (CVD) among people with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS We conducted a multiancestry time-to-event genome-wide association study for incident…
View article: <b>Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People with Type 2 Diabetes Mellitus</b>
<b>Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People with Type 2 Diabetes Mellitus</b> Open
OBJECTIVE To identify genetic risk factors for incident cardiovascular disease (CVD) among people with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS We conducted a multi-ancestry time-to-event genome-wide association study for inciden…
View article: <b>Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People with Type 2 Diabetes Mellitus</b>
<b>Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People with Type 2 Diabetes Mellitus</b> Open
OBJECTIVE To identify genetic risk factors for incident cardiovascular disease (CVD) among people with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS We conducted a multi-ancestry time-to-event genome-wide association study for inciden…