Liang Zhong
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View article: Albumin-bound paclitaxel and cisplatin with radiotherapy in locally advanced oesophageal squamous cell carcinoma: a single-arm, phase II trial
Albumin-bound paclitaxel and cisplatin with radiotherapy in locally advanced oesophageal squamous cell carcinoma: a single-arm, phase II trial Open
The trial was registered at https://clinicaltrials.gov under the identifier ChiCTR1900021079 in January 2019.
View article: Spatial separation of skin and edge states in non-Hermitian double-chain systems with unidirectional coupling
Spatial separation of skin and edge states in non-Hermitian double-chain systems with unidirectional coupling Open
In non-Hermitian systems, bulk states typically localize at the same edge as edge states, rendering this phenomenon a central focus in non-Hermitian topological physics. Here, we investigate the double-chain Su–Schrieffer–Heeger model with…
View article: Multifunctionality of tissue inhibitor of metalloproteinase-1 in central nervous system diseases
Multifunctionality of tissue inhibitor of metalloproteinase-1 in central nervous system diseases Open
Central nervous system (CNS) diseases are characterized by high morbidity, long disease courses, and irreversible neurological impairment, often resulting from damage to the neurovascular unit (NVU). Tissue inhibitor of metalloproteinase-1…
View article: Prognostic value of intra-cardiac blood kinetic energy assessed by 4D flow cardiac MRI in heart failure with reduced ejection fraction
Prognostic value of intra-cardiac blood kinetic energy assessed by 4D flow cardiac MRI in heart failure with reduced ejection fraction Open
CMR 4D flow-derived peak systolic KEi is associated with adverse outcomes and has the potential to serve as a novel imaging biomarker for risk stratification in HFrEF patients.
View article: Internal carotid artery bifurcation aneurysms are probably formed to decrease the abnormally-enhanced hemodynamic stresses caused by direct flow impaction
Internal carotid artery bifurcation aneurysms are probably formed to decrease the abnormally-enhanced hemodynamic stresses caused by direct flow impaction Open
ICA bifurcation aneurysm formation is closely associated with significantly decreased hemodynamic stresses, and aneurysm formation occurs to decrease the abnormally-enhanced hemodynamic parameters on the bifurcation apex caused by direct f…
View article: Integrated management strategies for benign prostatic hyperplasia
Integrated management strategies for benign prostatic hyperplasia Open
Benign prostatic hyperplasia (BPH) is a common condition in aging men, leading to lower urinary tract symptoms (LUTS) that affect quality of life. Treatment options have evolved from invasive surgeries to a combination of pharmacological t…
View article: Deep learning-based quantification of epicardial adipose tissue volume from non-contrast computed tomography images: a multi-centre study
Deep learning-based quantification of epicardial adipose tissue volume from non-contrast computed tomography images: a multi-centre study Open
Aims Epicardial adipose tissue (EAT), located within the pericardial sac, has emerged as a biomarker for coronary artery disease (CAD) progression. This study aimed to develop and validate a deep learning-based system for automated EAT vol…
View article: Correction: The electronic stethoscope
Correction: The electronic stethoscope Open
View article: Associations Between Right Ventricular Remodeling, Exercise and Circulating Metabolites in Volume and Pressure Overload States
Associations Between Right Ventricular Remodeling, Exercise and Circulating Metabolites in Volume and Pressure Overload States Open
PAH and rTOF exhibited distinct RV remodeling, and PAH, worse exercise tolerance. Differences in circulating branched chain amino acids and one-carbon metabolites were observed among rTOF, PAH, and control subjects.
View article: Interactions between membrane-bound streptococcal alpha-enolase and human plasminogen captured through cryogenic-electron microscopy
Interactions between membrane-bound streptococcal alpha-enolase and human plasminogen captured through cryogenic-electron microscopy Open
Certain invasive strains of the Gram-positive bacterium Streptococcus pyogenes exploit human plasminogen (hPg) to promote tissue invasion and pathogenesis. hPg is a single-chain multi-modular zymogen containing five kringle domains (K1-K5)…
View article: Challenges in Deep Learning-Based Small Organ Segmentation: A Benchmarking Perspective for Medical Research with Limited Datasets
Challenges in Deep Learning-Based Small Organ Segmentation: A Benchmarking Perspective for Medical Research with Limited Datasets Open
Accurate segmentation of carotid artery structures in histopathological images is vital for advancing cardiovascular disease research and diagnosis. However, deep learning model development in this domain is constrained by the scarcity of …
View article: Enhanced biogasification of bituminous coal via modified waste activated sludge-derived biochar
Enhanced biogasification of bituminous coal via modified waste activated sludge-derived biochar Open
View article: AGGF1-primed endothelial progenitor cells alleviate ischaemia-reperfusion injury in diabetic hearts
AGGF1-primed endothelial progenitor cells alleviate ischaemia-reperfusion injury in diabetic hearts Open
A number of cardioprotective pharmacological agents are not effective in diabetic hearts. The role of AGGF1-EPCs therapy in diabetic ischaemia-reperfusion(I/R) injury and the underlying mechanism by which AGGF1 regulates EPCs under hypergl…
View article: Haemodynamic implications of cardiovascular magnetic resonance pulmonary capillary wedge pressure in acute myocardial infarction
Haemodynamic implications of cardiovascular magnetic resonance pulmonary capillary wedge pressure in acute myocardial infarction Open
Aims Cardiovascular magnetic resonance (CMR)-derived pulmonary capillary wedge pressure (PCWP) has demonstrated diagnostic and prognostic utility in heart failure patients. However, its clinical value in acute myocardial infarction (AMI) r…
View article: An integrin-based quercetin 7-rhamnoside liver-targeted delivery liposomes for intrahepatic cholestasis in pregnancy
An integrin-based quercetin 7-rhamnoside liver-targeted delivery liposomes for intrahepatic cholestasis in pregnancy Open
Intrahepatic cholestasis in pregnancy (ICP) is a characteristic disease during the perinatal period; however, its therapy remains unsatisfactory, and the pathogenesis remains unclear. The ameliorative effect of naturally occurring querceti…
View article: Estimating Soil Cd Contamination in Wheat Farmland Using Hyperspectral Data and Interpretable Stacking Ensemble Learning
Estimating Soil Cd Contamination in Wheat Farmland Using Hyperspectral Data and Interpretable Stacking Ensemble Learning Open
Soil heavy metal pollution threatens agricultural safety and human health, with Cd exceeding standards being the most common problem in contaminated farmland. The development of hyperspectral remote sensing technology has provided a novel …
View article: Spatio-temporal Dynamics and Drivers of Phytoplankton Bloom in Dongting Lake from 2014-2022
Spatio-temporal Dynamics and Drivers of Phytoplankton Bloom in Dongting Lake from 2014-2022 Open
View article: Development and external validation of a nomogram prediction model based on quantitative coronary angiography for predicting ischemic lesions: a multi-centre study
Development and external validation of a nomogram prediction model based on quantitative coronary angiography for predicting ischemic lesions: a multi-centre study Open
Objectives Quantitative coronary angiography (QCA) has significantly contributed to the diagnosis of coronary artery disease. This study aimed to construct and validate a QCA-based prediction model, represented as a nomogram, for predictin…
View article: Safety and efficacy of the neuroform EZ stent for treating intracranial atherosclerotic stenosis in the posterior circulation: a comparative study of pre-procedure and post-procedure outcomes
Safety and efficacy of the neuroform EZ stent for treating intracranial atherosclerotic stenosis in the posterior circulation: a comparative study of pre-procedure and post-procedure outcomes Open
The Neuroform EZ stent is a safe and effective treatment approach for ICAS in the posterior circulation.
View article: 653 | EFFECTIVENESS AND GENOMIC LANDSCAPE OF FRONT‐LINE POLATUZUMAB‐BASED REGIMENS IN DIFFUSE LARGE B‐CELL LYMPHOMA: A REAL‐WORLD SINGLE‐CENTER STUDY ON TP53‐MUTATED SUBGROUPS
653 | EFFECTIVENESS AND GENOMIC LANDSCAPE OF FRONT‐LINE POLATUZUMAB‐BASED REGIMENS IN DIFFUSE LARGE B‐CELL LYMPHOMA: A REAL‐WORLD SINGLE‐CENTER STUDY ON TP53‐MUTATED SUBGROUPS Open
View article: ThinkSwitcher: When to Think Hard, When to Think Fast
ThinkSwitcher: When to Think Hard, When to Think Fast Open
Large reasoning models (LRMs) excel at solving complex tasks by leveraging long chain-of-thought (CoT) reasoning. However, this often leads to overthinking on simple tasks, resulting in unnecessary computational overhead. We observe that L…
View article: Precision Agriculture for Dragon Fruit: A Novel Approach Based on Nighttime Light Remote Sensing
Precision Agriculture for Dragon Fruit: A Novel Approach Based on Nighttime Light Remote Sensing Open
The dragon fruit industry holds significant market potential and is crucial for rural economic development. However, a comprehensive understanding and precise technical approach for analyzing the spatiotemporal dynamics of dragon fruit agr…
View article: Cardiovascular magnetic resonance imaging markers of ageing: a multi-centre, cross-sectional cohort study
Cardiovascular magnetic resonance imaging markers of ageing: a multi-centre, cross-sectional cohort study Open
Aims Cardiac ageing involves a series of anatomical and physiological changes contributing to a decline in overall performance. Cardiac magnetic resonance (CMR) provides comprehensive structural and functional assessment for detecting age-…
View article: FuseRL: Dense Preference Optimization for Heterogeneous Model Fusion
FuseRL: Dense Preference Optimization for Heterogeneous Model Fusion Open
Heterogeneous model fusion enhances the performance of LLMs by integrating the knowledge and capabilities of multiple structurally diverse models. However, existing approaches often rely solely on selecting the best output for each prompt …
View article: Characterization and cross-reactivity assessment of group-29 allergens originating from Dermatophagoides pteronyssinus, Dermatophagoides farinae, and Tyrophagus putrescentiae
Characterization and cross-reactivity assessment of group-29 allergens originating from Dermatophagoides pteronyssinus, Dermatophagoides farinae, and Tyrophagus putrescentiae Open
Objective: To characterize the group-29 allergens from Dermatophagoides (D.) pteronyssinus and investigate their ability to cross-react with other group-29 allergens from D. pteronyssinus as well as those from D. farinae and Tyrophagus put…
View article: AGGF1-primed endothelial progenitor cells alleviate ischaemia-reperfusion injury in diabetic hearts
AGGF1-primed endothelial progenitor cells alleviate ischaemia-reperfusion injury in diabetic hearts Open
A number of cardioprotective pharmacological agents are not effective in diabetic hearts. The role of AGGF1-EPCs therapy in diabetic ischaemia-reperfusion（I/R） injury and the underlying mechanism by which AGGF1 regulates EPCs under hypergl…
View article: Wnt Inhibition Safeguards Porcine Embryonic Stem Cells From the Acquisition of Extraembryonic Endoderm Cell Fates
Wnt Inhibition Safeguards Porcine Embryonic Stem Cells From the Acquisition of Extraembryonic Endoderm Cell Fates Open
Porcine embryonic stem cells (ESCs) are excellent models for exploring embryogenesis, producing genetically enhanced farm animals, and improving breeding. Various chemicals have been applied to generate porcine ESCs from embryos, which dif…
View article: FuseChat-3.0: Preference Optimization Meets Heterogeneous Model Fusion
FuseChat-3.0: Preference Optimization Meets Heterogeneous Model Fusion Open
We introduce FuseChat-3.0, a suite of large language models (LLMs) developed by integrating the strengths of heterogeneous source LLMs into more compact target LLMs. Our source models include the powerful Gemma-2-27B-it, Mistral-Large-Inst…
View article: The research progress and future directions in the pathophysiological mechanisms of type 2 diabetes mellitus from the perspective of precision medicine
The research progress and future directions in the pathophysiological mechanisms of type 2 diabetes mellitus from the perspective of precision medicine Open
Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder characterized by pathophysiological mechanisms such as insulin resistance and β -cell dysfunction. Recent advancements in T2DM research have unveiled intricate multi-level reg…
View article: Harnessing oleaginous protist Schizochytrium for docosahexaenoic acid: Current technologies in sustainable production and food applications
Harnessing oleaginous protist Schizochytrium for docosahexaenoic acid: Current technologies in sustainable production and food applications Open
Docosahexaenoic acid (DHA) exerts versatile roles in nutrition supplementation and numerous health disorders prevention. Global consumption demand for DHA has also been consistently increasing with enhanced health awareness. Oleaginous mar…