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View article: Lymphocyte Profile Analysis in Lymph Node Puncture Fluid of Mediastinal Reactive Lymphadenopathy and Its Value in Differential Diagnosis with Tuberculous Lymphadenitis
Lymphocyte Profile Analysis in Lymph Node Puncture Fluid of Mediastinal Reactive Lymphadenopathy and Its Value in Differential Diagnosis with Tuberculous Lymphadenitis Open
A total of 41 TBLA cases and 45 RL cases were included. Compared with the TBLA group, the RL group exhibited increased proportions of CD4⁺ T cells and B cells, and decreased proportions of CD8⁺ T cells, natural killer (NK) cells, and natur…
View article: Biomechanical Mechanisms of Early Gait Training on Knee Cartilage Degeneration After Anterior Cruciate Ligament Reconstruction：a protocol for RCT
Biomechanical Mechanisms of Early Gait Training on Knee Cartilage Degeneration After Anterior Cruciate Ligament Reconstruction：a protocol for RCT Open
ObjectiveThe primary objective of this study is to investigate the effects and biomechanical mechanisms of early gait retraining (GRT) on knee cartilage degeneration following anterior cruciate ligament reconstruction (ACLR).MethodsThis st…
View article: A Comparative Evaluation of Harmonic Analysis and Neural Networks for Sea Level Prediction in the Northern South China Sea
A Comparative Evaluation of Harmonic Analysis and Neural Networks for Sea Level Prediction in the Northern South China Sea Open
Long-term sea level variations in the northern South China Sea (SCS) are known to significantly impact coastal ecosystems and socio-economic activities. To improve sea level prediction accuracy, four models—harmonic analysis and three arti…
View article: Deep learning algorithms from histopathological images stratify molecular subtypes for leiomyosarcoma: a proof-and-concept diagnostic study
Deep learning algorithms from histopathological images stratify molecular subtypes for leiomyosarcoma: a proof-and-concept diagnostic study Open
Background: The leiomyosarcoma (LMS) is the most common soft tissue sarcoma, and its molecular subtypes were identified with therapeutic sensitivity and prognosis. We aimed to develop and validate deep learning (DL) algorithms to stratify …
View article: Characterization of Walls Are Thin 1 Family in Cucumis sativus and Functional Identification of CsWAT1-20 in Response to Podosphaera xanthii
Characterization of Walls Are Thin 1 Family in Cucumis sativus and Functional Identification of CsWAT1-20 in Response to Podosphaera xanthii Open
Cucumber (Cucumis sativus) is an economically important vegetable but powdery mildew (caused by Podosphaera xanthii) limits cucumber production. The WALLS ARE THIN1 (WAT1) gene is crucial for regulating secondary cell wall thickness and is…
View article: Polarization-sensitive symmetry-protected bound states in the continuum in Dirac semimetal metasurface: a comparative study and application to refractive index sensing
Polarization-sensitive symmetry-protected bound states in the continuum in Dirac semimetal metasurface: a comparative study and application to refractive index sensing Open
We have designed an actively tunable, polarization-sensitive, symmetry-protected quasi-BIC metasurface based on Dirac semimetals (DS), featuring a silicon dioxide (SiO 2 ) substrate and a resonant unit of three DS strips. A comparative stu…
View article: Development and Validation of a Nomogram Prediction Model for Moderate-to-Severe Acute Radiation Dermatitis in Patients with Breast Cancer: A Retrospective Study
Development and Validation of a Nomogram Prediction Model for Moderate-to-Severe Acute Radiation Dermatitis in Patients with Breast Cancer: A Retrospective Study Open
Aims/Background Acute radiation dermatitis is the most common complication of radiotherapy in patients with breast cancer, with mild severity relieved by symptomatic treatment and moderate-to-severe severity leading to compromised skin int…
View article: Effects of traditional Chinese medicine on symptoms of patients with spleen and stomach deficiency-related tinnitus
Effects of traditional Chinese medicine on symptoms of patients with spleen and stomach deficiency-related tinnitus Open
BACKGROUND Tinnitus affects 10%-30% of the population. Recent evidence suggests that tinnitus is associated with spleen deficiency. However, compared with kidney deficiency-related tinnitus, less research has been conducted on the impact o…
View article: Efficacy and safety of early prone position in postoperative cardiac surgery adults with acute respiratory distress syndrome: a single-center retrospective cohort study
Efficacy and safety of early prone position in postoperative cardiac surgery adults with acute respiratory distress syndrome: a single-center retrospective cohort study Open
Early PP treatment is effective and safe for patients with moderate to severe ARDS after cardiac surgery and it is even safe in a subgroup placed with IABP.
View article: The Spatial Impact of Innovation Efficiency on Green Development
The Spatial Impact of Innovation Efficiency on Green Development Open
Innovation and green development are important aspects of a country’s economic and social development. Exploring the impact of innovation on green development from a spatial perspective can help local governments suggest measures to promot…
View article: Multi-Response Optimization and Experimental Investigation of the Influences of Various Coolant Conditions on the Milling of Alloy 20
Multi-Response Optimization and Experimental Investigation of the Influences of Various Coolant Conditions on the Milling of Alloy 20 Open
This study investigates the machining processes of Alloy 20 under different cooling conditions: Minimum Quantity Lubrication (MQL), Carbon Dioxide (CO2), and the hybrid MQL + CO2 approach. The research focuses on optimizing the cutting par…
View article: Cryoprotective Activity of Different Characterized Fractions Isolated from Enzymatic Hydrolysates of Croceine Croaker (Pseudosciaena crocea)
Cryoprotective Activity of Different Characterized Fractions Isolated from Enzymatic Hydrolysates of Croceine Croaker (Pseudosciaena crocea) Open
In this study, ultrafiltration fractions (3 k Da, HMH) and solid-phase extraction fractions (hydrophilic hydrolysate, HIH; hydrophobic hydrolysate, HOH) from trypsin hydrolysate purified from croceine croaker (Pseudosciaena crocea) isolate…
View article: The model for predicting the central lymph node metastasis in cN0 papillary thyroid microcarcinoma with Hashimoto’s thyroiditis
The model for predicting the central lymph node metastasis in cN0 papillary thyroid microcarcinoma with Hashimoto’s thyroiditis Open
Background The relationship between Hashimoto’s thyroiditis (HT) and papillary thyroid microcarcinoma (PTMC) is controversial. These include central lymph node metastasis (CLNM), which affects the prognosis of PTMC patients. This study aim…
View article: A bilevel programming model for cross-regional energy coordination mechanism to relieve China’s atmospheric pollution
A bilevel programming model for cross-regional energy coordination mechanism to relieve China’s atmospheric pollution Open
The research motivation comes from the fact that the vigorously promoted 'coal to gas'policy under the pressure of China's Ministry of Environmental Protection(MEP) has led to severe gas shortage in many regions. This study explores a cros…
View article: Recycling of Aluminosilicate-Based Solid Wastes through Alkali-Activation: Preparation, Characterization, and Challenges
Recycling of Aluminosilicate-Based Solid Wastes through Alkali-Activation: Preparation, Characterization, and Challenges Open
Recycling aluminosilicate-based solid wastes is imperative to realize the sustainable development of constructions. By using alkali activation technology, aluminosilicate-based solid wastes, such as furnace slag, fly ash, red mud, and most…
View article: Research on the Collaborative Teaching Model of “One Lesson, Multiple Teachers” in China Based on the OBE Concept
Research on the Collaborative Teaching Model of “One Lesson, Multiple Teachers” in China Based on the OBE Concept Open
From a policy orientation perspective, China is increasingly focusing on the quality of talent cultivation and reform of teaching models. There is a gear effect between the OBE (Outcome Based Education) concept and the collaborative teachi…
View article: Knowledge Maps Analysis of Language Poverty Alleviation Research in China Based on the CiteSpace Method
Knowledge Maps Analysis of Language Poverty Alleviation Research in China Based on the CiteSpace Method Open
Poverty is a global problem, and in order to eliminate it, China has enacted a variety of policies, and the cause of poverty alleviation and reduction has achieved world-renowned success. At the same time, China's language poverty alleviat…
View article: Protective effect of alirocumab, a PCSK9 inhibitor, on the sciatic nerve of rats with diabetic peripheral neuropathy
Protective effect of alirocumab, a PCSK9 inhibitor, on the sciatic nerve of rats with diabetic peripheral neuropathy Open
Dyslipidemia has been considered a risk factor for diabetic peripheral neuropathy. Proprotein convertase subtilisin-like/Kexin 9 inhibitor (PCSK9) inhibitors are a new type of lipid-lowering drug currently in clinical use. The role of PCSK…
View article: ISG15 accelerates acute kidney injury and the subsequent AKI-to-CKD transition by promoting TGFβR1 ISGylation
ISG15 accelerates acute kidney injury and the subsequent AKI-to-CKD transition by promoting TGFβR1 ISGylation Open
Rationale: Acute kidney injury (AKI) has substantial rates of mortality and morbidity, coupled with an absence of efficacious treatment options. AKI commonly transits into chronic kidney disease (CKD) and ultimately culminates in end-stage…
View article: Effectiveness of tele-rehabilitation after total hip replacement: a systematic review and meta-analysis of randomized controlled trials
Effectiveness of tele-rehabilitation after total hip replacement: a systematic review and meta-analysis of randomized controlled trials Open
In this systematic review and meta-analysis, internet-based tele-rehabilitation and face-to-face rehabilitation had the same effect on patients after total hip replacement, and compliance was higher in the tele-rehabilitation group, but at…
View article: Research Progress on the Mechanism of Androgen Receptor Signaling Pathway in Castration-Resistant Prostate Cancer
Research Progress on the Mechanism of Androgen Receptor Signaling Pathway in Castration-Resistant Prostate Cancer Open
Prostate cancer (Pca) remains the most common malignancy worldwide in men, and the second leading cause of mortality only to lung cancer. Besides surgery, androgen deprivation therapy (ADT) is a major treatment for Pca. However, ADT leads …
View article: Risk factors predicting pathological degradation after cervical excision in cervical intraepithelial neoplasia grade II P16-positive patients over 25 years old: a cross-sectional study
Risk factors predicting pathological degradation after cervical excision in cervical intraepithelial neoplasia grade II P16-positive patients over 25 years old: a cross-sectional study Open
A higher rate of pathological downgrading after CKC was found in CINII/P16-positive patients who were aged over 25 years. Overtreatment exists in patients with CINII/P16-positive diagnosis. Independent factors for pathological downgrading …
View article: <scp>α‐Synuclein</scp> induces deficiency in clathrin‐mediated endocytosis through inhibiting synaptojanin1 expression
<span>α‐Synuclein</span> induces deficiency in clathrin‐mediated endocytosis through inhibiting synaptojanin1 expression Open
Parkinson's disease (PD) is an age‐related chronic neurological disorder, mainly characterized by the pathological feature of α‐synuclein (α‐syn) aggregation, with the exact disease pathogenesis unclear. During the onset and progression of…
View article: Supplementary Table S1. from Phase II Study of Taselisib (GDC-0032) in Combination with Fulvestrant in Patients with HER2-Negative, Hormone Receptor–Positive Advanced Breast Cancer
Supplementary Table S1. from Phase II Study of Taselisib (GDC-0032) in Combination with Fulvestrant in Patients with HER2-Negative, Hormone Receptor–Positive Advanced Breast Cancer Open
Study disposition
View article: Supplemental Methods from Phase II Study of Taselisib (GDC-0032) in Combination with Fulvestrant in Patients with HER2-Negative, Hormone Receptor–Positive Advanced Breast Cancer
Supplemental Methods from Phase II Study of Taselisib (GDC-0032) in Combination with Fulvestrant in Patients with HER2-Negative, Hormone Receptor–Positive Advanced Breast Cancer Open
Definition of adverse events of special interest (AESI)