Wenguo Cui
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View article: Combined M1 macrophage inhibition and thermotherapy for controlled fibroplasia and accelerated wound repair via an oxygenating ROS-responsive hydrogel
Combined M1 macrophage inhibition and thermotherapy for controlled fibroplasia and accelerated wound repair via an oxygenating ROS-responsive hydrogel Open
Wound healing remains a major clinical challenge, as hypoxia, oxidative stress, and immune dysregulation collectively impede tissue regeneration. To overcome these multifactorial barriers, we developed an injectable hydrogel (FH-PMC-T) by …
View article: Influence of Micro- and Nanoscale Cues on Immune Factors Secretion: Implications for Immunomodulation
Influence of Micro- and Nanoscale Cues on Immune Factors Secretion: Implications for Immunomodulation Open
Immune factors secreted by immune cells play a pivotal role in orchestrating inflammatory responses and facilitating tissue regeneration. Fiber dressings, owing to their extracellular matrix–like architecture and tunable physical propertie…
View article: 3D printed scaffolds regulated by neural-bone metabolic coupling promote bone unit regeneration
3D printed scaffolds regulated by neural-bone metabolic coupling promote bone unit regeneration Open
The bone unit (BU) is a multicellular functional unit composed of neuromodulatory networks, bone tissue, and functional blood vessels. As a functional extension of bone regeneration, the BU coordinates neural signal, regeneration of the ci…
View article: Electrosensitive Heterogeneous Short Fibers via Acousto‐Electric Coupling for Sequential Bone Regeneration in Infectious Defects
Electrosensitive Heterogeneous Short Fibers via Acousto‐Electric Coupling for Sequential Bone Regeneration in Infectious Defects Open
The disruption of dynamic equilibrium between antimicrobial and osteogenic processes, caused by the heterogeneous electro‐sensitivity of bacteria and host cells, is central to the high failure rate in repairing infected bone defects. This …
View article: Integrated ‘Shield‐Spear’ Biological Patch for Fibrosis‐Free Bladder Reconstruction
Integrated ‘Shield‐Spear’ Biological Patch for Fibrosis‐Free Bladder Reconstruction Open
Bladder reconstruction without fibrosis remains a global challenge. Current bladder defect treatments primarily focus on repair at the level of vascularization, failing to balance healing and excessive collagen deposition, and neglecting t…
View article: Quercetin attenuates tendon stem/progenitor cell senescence and promotes aged tendon repair via AKT/NF-κB/NLRP3-mediated mitophagy activation
Quercetin attenuates tendon stem/progenitor cell senescence and promotes aged tendon repair via AKT/NF-κB/NLRP3-mediated mitophagy activation Open
Our findings suggest quercetin could alleviate senescent phenotypes in TSPCs through AKT-mediated mitochondrial stabilization and SASP suppression. The DPH@QUE delivery system enables effective translation of these anti-aging effects into …
View article: A multicellular self-organized probiotic platform for oral delivery enhances intestinal colonization
A multicellular self-organized probiotic platform for oral delivery enhances intestinal colonization Open
Stable gut colonization of probiotics is essential for sustained therapeutic effects, however traditional oral probiotic supplements often fail to adapt to the gut environment. Here, based on the observation that multicellular microcolonie…
View article: Supramolecular Lubricating Hydrogel Microspheres Reshape Damaged Matrix Regeneration
Supramolecular Lubricating Hydrogel Microspheres Reshape Damaged Matrix Regeneration Open
Supramolecular lubrication refers to lubricant supplementation utilizing intermolecular noncovalent interactions to remodel lubrication structure at biological interfaces. The previous studies found that lubrication supplementation is clos…
View article: Three-stage sequential targeted nasal drops for correcting abnormal mitochondrial division in microglia
Three-stage sequential targeted nasal drops for correcting abnormal mitochondrial division in microglia Open
Abnormal mitochondrial division in microglia significantly impacts central nervous system (CNS) diseases. However, treating CNS diseases through microglial mitochondria presents several challenges: intracerebral delivery of drugs, microgli…
View article: Aging‐Regulating Microspheres for Enhancing Mitochondrial Biogenesis in Early Senescence and Clearing Late Senescent Cells
Aging‐Regulating Microspheres for Enhancing Mitochondrial Biogenesis in Early Senescence and Clearing Late Senescent Cells Open
Targeting senescent cells represents a promising strategy for treating degenerative diseases. Within the senescent microenvironment of degenerating tissues, two distinct types of senescent cells coexist: early senescent cells, characterize…
View article: Surface‐Bound Gene‐Functionalized Injectable Short Fibers via Reversing Collagen Aging for Inhibiting Intervertebral Disc Degeneration
Surface‐Bound Gene‐Functionalized Injectable Short Fibers via Reversing Collagen Aging for Inhibiting Intervertebral Disc Degeneration Open
Collagen aging, which results from senescent nucleus pulposus (NP) cells, is a key factor in intervertebral disc degeneration (IDD). Traditional therapies that target the removal of senescent cells fail to address the underlying problem of…
View article: The Application of Microfluidic Chips in Primary Urological Cancer: Recent Advances and Future Perspectives
The Application of Microfluidic Chips in Primary Urological Cancer: Recent Advances and Future Perspectives Open
The research of primary urological cancers, including bladder cancer (BCa), prostate cancer (PCa), and renal cancer (RCa), has developed rapidly. Microfluidic technology provides a good variety of benefits compared to the heterogeneity of …
View article: Apoptotic Bodies Restore NAD and Mitochondrial Homeostasis in Fibroblasts
Apoptotic Bodies Restore NAD and Mitochondrial Homeostasis in Fibroblasts Open
Fibrotic skin diseases are characterized by excessive fibroblast proliferation and pathological extracellular matrix deposition. As a pivotal coenzyme in cellular energetics, NAD homeostasis perturbation is implicated in fibrosis. Multiple…
View article: Decursin‐Loaded Nanovesicles Target Macrophages Driven by the Pathological Process of Atherosclerosis
Decursin‐Loaded Nanovesicles Target Macrophages Driven by the Pathological Process of Atherosclerosis Open
Atherosclerosis (AS) is a major pathological factor contributing to the mortality associated with ischemic heart disease and is driven primarily by macrophage‐mediated lipid accumulation and inflammatory processes. Conventional cardiovascu…
View article: Ultrasound‐Driven Electric Conversion Hydrogel Coating Enhances Macrophage Efferocytosis for Non‐Invasive Skin Expansion
Ultrasound‐Driven Electric Conversion Hydrogel Coating Enhances Macrophage Efferocytosis for Non‐Invasive Skin Expansion Open
Skin soft‐tissue expansion, a key technique for tissue regeneration, promotes tissue repair by applying sustained mechanical tension. However, prolonged tension leads to the accumulation of apoptotic cells and impaired macrophage efferocyt…
View article: Manipulation of Oxygen Tension in Damaged Regions via Hypoxia‐Induced IPN Hydrogel Microspheres for Intervertebral Disc Regeneration
Manipulation of Oxygen Tension in Damaged Regions via Hypoxia‐Induced IPN Hydrogel Microspheres for Intervertebral Disc Regeneration Open
Disruption of low oxygen tension homeostasis during intervertebral disc degeneration inhibits endogenous stem cell viability and function, posing a challenge for endogenous regeneration. Here, to achieve sustained hypoxia manipulation, con…
View article: Stable and Integrated Nanocellulose‐Covered Stents via In Situ Microbial Synthesis
Stable and Integrated Nanocellulose‐Covered Stents via In Situ Microbial Synthesis Open
Membrane covering stents are gaining significant importance in the management of intracavitary diseases, particularly in cases where bare metal stents are inappropriate, such as those involving intracavitary tumors and leaks. It is becomin…