Wensheng Zhang
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View article: Biomimetic Chlorosomes: Oxygen‐Independent Photocatalytic Nanoreactors for Efficient Combination Photoimmunotherapy
Biomimetic Chlorosomes: Oxygen‐Independent Photocatalytic Nanoreactors for Efficient Combination Photoimmunotherapy Open
Photocatalytic therapy for hypoxic tumors often suffers from inefficiencies due to its dependence on oxygen and the risk of uncontrolled activation. Inspired by the oxygen‐independent and precisely regulated photocatalytic functions of nat…
View article: AdaptGCD: Multi-Expert Adapter Tuning for Generalized Category Discovery
AdaptGCD: Multi-Expert Adapter Tuning for Generalized Category Discovery Open
Different from the traditional semi-supervised learning paradigm that is constrained by the close-world assumption, Generalized Category Discovery (GCD) presumes that the unlabeled dataset contains new categories not appearing in the label…
View article: ERK5 promotes autocrine expression to sustain mitogenic balance for cell fate specification in human pluripotent stem cells
ERK5 promotes autocrine expression to sustain mitogenic balance for cell fate specification in human pluripotent stem cells Open
View article: Leveraging Senescent Cancer Cell Membrane to Potentiate Cancer Immunotherapy Through Biomimetic Nanovaccine
Leveraging Senescent Cancer Cell Membrane to Potentiate Cancer Immunotherapy Through Biomimetic Nanovaccine Open
Senescent cancer cells are endowed with high immunogenic potential that has been leveraged to elicit antitumor immunity and potentially complement anticancer therapies. However, the efficacy of live senescent cancer cell‐based vaccination …
View article: Data from Comprehensive Analysis of Multiple Cohort Datasets Deciphers the Utility of Germline Single-Nucleotide Polymorphisms in Prostate Cancer Diagnosis
Data from Comprehensive Analysis of Multiple Cohort Datasets Deciphers the Utility of Germline Single-Nucleotide Polymorphisms in Prostate Cancer Diagnosis Open
Prostate cancer susceptibility is a polygenic trait. We aimed to examine the controversial diagnostic utility of single-nucleotide polymorphisms (SNP) for prostate cancer. We analyzed two datasets collected from Europeans and one from Afri…
View article: Supplementary Data from Comprehensive Analysis of Multiple Cohort Datasets Deciphers the Utility of Germline Single-Nucleotide Polymorphisms in Prostate Cancer Diagnosis
Supplementary Data from Comprehensive Analysis of Multiple Cohort Datasets Deciphers the Utility of Germline Single-Nucleotide Polymorphisms in Prostate Cancer Diagnosis Open
Text S1, Text S2, Text S3, Text S4, Figure S1, Table S1, Table S2
View article: Data from Comprehensive Analysis of Multiple Cohort Datasets Deciphers the Utility of Germline Single-Nucleotide Polymorphisms in Prostate Cancer Diagnosis
Data from Comprehensive Analysis of Multiple Cohort Datasets Deciphers the Utility of Germline Single-Nucleotide Polymorphisms in Prostate Cancer Diagnosis Open
Prostate cancer susceptibility is a polygenic trait. We aimed to examine the controversial diagnostic utility of single-nucleotide polymorphisms (SNP) for prostate cancer. We analyzed two datasets collected from Europeans and one from Afri…
View article: Supplementary Data from Comprehensive Analysis of Multiple Cohort Datasets Deciphers the Utility of Germline Single-Nucleotide Polymorphisms in Prostate Cancer Diagnosis
Supplementary Data from Comprehensive Analysis of Multiple Cohort Datasets Deciphers the Utility of Germline Single-Nucleotide Polymorphisms in Prostate Cancer Diagnosis Open
Text S1, Text S2, Text S3, Text S4, Figure S1, Table S1, Table S2
View article: PHF6 recruits BPTF to promote HIF-dependent pathway and progression in YAP-high breast cancer
PHF6 recruits BPTF to promote HIF-dependent pathway and progression in YAP-high breast cancer Open
Background Aberrant epigenetic remodeling events contribute to progression and metastasis of breast cancer (Bca). The specific mechanims that epigenetic factors rely on to mediate tumor aggressiveness remain unclear. We aimed to elucidate …
View article: Quantifying the Contributions of Environmental Factors to Prostate Cancer and Detecting Risk-Related Diet Metrics and Racial Disparities
Quantifying the Contributions of Environmental Factors to Prostate Cancer and Detecting Risk-Related Diet Metrics and Racial Disparities Open
The relevance of nongenetic factors to prostate cancer (PCa) has been elusive. We aimed to quantify the contributions of environmental factors to PCa and identify risk-related diet metrics and relevant racial disparities. We performed a un…
View article: A transcriptomic signature for prostate cancer relapse prediction identified from the differentially expressed genes between TP53 mutant and wild-type tumors
A transcriptomic signature for prostate cancer relapse prediction identified from the differentially expressed genes between TP53 mutant and wild-type tumors Open
For prostate cancer (PCa) patients, biochemical recurrence (BCR) is the first sign of disease relapse and the subsequent metastasis. TP53 mutations are relatively prevalent in advanced PCa forms. We aimed to utilize this knowledge to ident…
View article: LncRNA ITGB2-AS1 promotes the progression of clear cell renal cell carcinoma by modulating miR-328-5p/HMGA1 axis
LncRNA ITGB2-AS1 promotes the progression of clear cell renal cell carcinoma by modulating miR-328-5p/HMGA1 axis Open
Clear cell renal cell carcinoma (ccRCC) is the most common histologic subtype of renal cell carcinoma and long non-coding RNAs (lncRNAs) play important roles in the progression of ccRCC. In this study, we aim to explore the potential funct…
View article: Comprehensive Analysis of Multiple Cohort Datasets Deciphers the Utility of Germline Single-Nucleotide Polymorphisms in Prostate Cancer Diagnosis
Comprehensive Analysis of Multiple Cohort Datasets Deciphers the Utility of Germline Single-Nucleotide Polymorphisms in Prostate Cancer Diagnosis Open
Prostate cancer susceptibility is a polygenic trait. We aimed to examine the controversial diagnostic utility of single-nucleotide polymorphisms (SNP) for prostate cancer. We analyzed two datasets collected from Europeans and one from Afri…
View article: Quantitative Proteomic Profiling Identifies a Potential Novel Chaperone Marker in Resistant Breast Cancer
Quantitative Proteomic Profiling Identifies a Potential Novel Chaperone Marker in Resistant Breast Cancer Open
Development of aromatase inhibitor resistant breast cancer among postmenopausal women continues to be a major clinical obstacle. Previously, our group demonstrated that as breast cancer cells transition from hormone-dependent to hormone-in…
View article: Gene expression analysis reveals a pitfall in the molecular research of prostate tumors relevant to Gleason score
Gene expression analysis reveals a pitfall in the molecular research of prostate tumors relevant to Gleason score Open
Gleason score (GS) is a powerful prognostic factor in prostate cancer (PCa). A GS-7 tumor typically has the primary Gleason (architectural) pattern and secondary prevalent one being graded with 3 and 4 (or 4 and 3), respectively. Due to th…
View article: SEER and Gene Expression Data Analysis Deciphers Racial Disparity Patterns in Prostate Cancer Mortality and the Public Health Implication
SEER and Gene Expression Data Analysis Deciphers Racial Disparity Patterns in Prostate Cancer Mortality and the Public Health Implication Open
View article: Genetic structure, gene flow pattern, and association analysis of superior germplasm resources in domesticated upland cotton (Gossypium hirsutum L.)
Genetic structure, gene flow pattern, and association analysis of superior germplasm resources in domesticated upland cotton (Gossypium hirsutum L.) Open
View article: Progress in Synthesis of <i>N</i>-Sulfonyl-1,2,3-triazole and Its Application in Organic Synthesis
Progress in Synthesis of <i>N</i>-Sulfonyl-1,2,3-triazole and Its Application in Organic Synthesis Open
N-Sulfonyl-1,2,3-triazole, an important class of five-membered nitrogen-containing organic compounds, has been found processing widespread application in the synthesis of various nitrogen-containing organic compounds, especially heterocycl…
View article: Cinnamaldehyde causes apoptosis of myeloid‑derived suppressor cells through the activation of TLR4
Cinnamaldehyde causes apoptosis of myeloid‑derived suppressor cells through the activation of TLR4 Open
Malignant tumors are among the most life-threatening diseases in the world. Although many different types of antitumor agents are available, severe side effects and toxicity limit their applications. Myeloid-derived suppressor cells (MDSCs…
View article: Resequencing core accessions of a pedigree identifies derivation of genomic segments and key agronomic trait loci during cotton improvement
Resequencing core accessions of a pedigree identifies derivation of genomic segments and key agronomic trait loci during cotton improvement Open
Summary Upland cotton ( Gossypium hirsutum ) is the world's largest source of natural fibre and dominates the global textile industry. Hybrid cotton varieties exhibit strong heterosis that confers high fibre yields, yet the genome‐wide eff…
View article: Abstract QS29: Study of the Retinochoroidal Circulation with Fluorescein Angiography in a Rodent Orthotopic Whole Eye Transplantation Model
Abstract QS29: Study of the Retinochoroidal Circulation with Fluorescein Angiography in a Rodent Orthotopic Whole Eye Transplantation Model Open
PURPOSE: Whole eye transplantation (WET) could potentially provide a viable optical system to people worldwide with irreversible vision loss. As a first step toward realizing this goal, we have developed an orthotopic model for whole eye t…
View article: Comparative Chloroplast Genomics of Gossypium Species: Insights Into Repeat Sequence Variations and Phylogeny
Comparative Chloroplast Genomics of Gossypium Species: Insights Into Repeat Sequence Variations and Phylogeny Open
Cotton is one of the most economically important fiber crop plants worldwide. The genus Gossypium contains a single allotetraploid group (AD) and eight diploid genome groups (A-G and K). However, the evolution of repeat sequences in…
View article: MicroRNA-19 contributes to the malignant phenotypes of osteosarcoma in vitro by targeting Pax6
MicroRNA-19 contributes to the malignant phenotypes of osteosarcoma in vitro by targeting Pax6 Open
This study was conducted to detect the expression of miR-19 and Pax6 (Paired box protein 6) in human osteosarcoma cells and the effects on biological characteristics of osteosarcoma cells. Quantitative real-time polymerase chain reaction w…
View article: Eugenol triggers CD11b<sup>+</sup>Gr1<sup>+</sup>myeloid-derived suppressor cell apoptosis<i>via</i>endogenous apoptosis pathway
Eugenol triggers CD11b<sup>+</sup>Gr1<sup>+</sup>myeloid-derived suppressor cell apoptosis<i>via</i>endogenous apoptosis pathway Open
To study the effect and underlying molecular mechanism of eugenol on CD11b+Gr1+myeloid-derived suppressor cells (MDSCs).
View article: Racial disparities in patient survival and tumor mutation burden, and the association between tumor mutation burden and cancer incidence rate
Racial disparities in patient survival and tumor mutation burden, and the association between tumor mutation burden and cancer incidence rate Open
View article: A polysaccharide derived from Lentinus edodes impairs the immunosuppressive function of myeloid-derived suppressor cells via the p38 pathways
A polysaccharide derived from Lentinus edodes impairs the immunosuppressive function of myeloid-derived suppressor cells via the p38 pathways Open
MPSSS may reverse the function of the MSC2 cells through p38 activation and ERK suppression and provide a novel anti-cancer strategy by targeting myeloid immune suppressor cells.
View article: Mutant TP53 disrupts age-related accumulation patterns of somatic mutations in multiple cancer types
Mutant TP53 disrupts age-related accumulation patterns of somatic mutations in multiple cancer types Open
View article: Integrative Genomics and Transcriptomics Analysis Reveals Potential Mechanisms for Favorable Prognosis of Patients with HPV-Positive Head and Neck Carcinomas
Integrative Genomics and Transcriptomics Analysis Reveals Potential Mechanisms for Favorable Prognosis of Patients with HPV-Positive Head and Neck Carcinomas Open
View article: Highly and moderately aggressive mouse ovarian cancer cell lines exhibit differential gene expression
Highly and moderately aggressive mouse ovarian cancer cell lines exhibit differential gene expression Open
View article: Hyperinsulinemia enhances interleukin-17-induced inflammation to promote prostate cancer development in obese mice through inhibiting glycogen synthase kinase 3-mediated phosphorylation and degradation of interleukin-17 receptor
Hyperinsulinemia enhances interleukin-17-induced inflammation to promote prostate cancer development in obese mice through inhibiting glycogen synthase kinase 3-mediated phosphorylation and degradation of interleukin-17 receptor Open
Interleukin-17 (IL-17) plays important roles in inflammation, autoimmune diseases, and some cancers. Obese people are in a chronic inflammatory state with increased serum levels of IL-17, insulin, and insulin-like growth factor 1 (IGF1). H…