Cuiyun Liu
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View article: Prodrug nanoassembly technology for colorectal cancer therapy
Prodrug nanoassembly technology for colorectal cancer therapy Open
The clinical efficacy of Irinotecan is constrained by individual variability in its enzymatic conversion to the active metabolite, SN38. While direct administration of SN38 bypasses this enzymatic process and demonstrates potent anti-tumor…
View article: Mixed Metal Metal-Organic Framework Synergized with Functional Liposomes Boosts Bipolar-Driven Organic Photoelectrochemical Transistor for Highly Sensitive Biodetection
Mixed Metal Metal-Organic Framework Synergized with Functional Liposomes Boosts Bipolar-Driven Organic Photoelectrochemical Transistor for Highly Sensitive Biodetection Open
View article: The Regulation of SPRY4 Intronic Transcript 1 (SPRY4-IT1) on KIT Signaling and Imatinib Resistance of Gastrointestinal Stromal Tumor (GIST) Cells
The Regulation of SPRY4 Intronic Transcript 1 (SPRY4-IT1) on KIT Signaling and Imatinib Resistance of Gastrointestinal Stromal Tumor (GIST) Cells Open
BACKGROUND: SPRY4 intronic transcript 1 (SPRY4-IT1), is a long non-coding RNA coded by the intron of SPRY4. SPRY4 is highly expressed in gastrointestinal stromal tumor (GIST) and inhibits the tumorigenesis of GIST, but whether SPRY4-IT1 re…
View article: Advances in the study of AIE polymers
Advances in the study of AIE polymers Open
Aggregation-induced emission (AIE) can exhibit different properties in different situations, such as non-emission and highly fluorescent in the dissolved state of the molecule and in the aggregate or solid state, respectively. This propert…
View article: The function and therapeutic potential of transfer RNA-derived small RNAs in cardiovascular diseases: A review
The function and therapeutic potential of transfer RNA-derived small RNAs in cardiovascular diseases: A review Open
Transfer RNA-derived small RNAs (tsRNAs) are a class of small non-coding RNA (sncRNA) molecules derived from tRNA, including tRNA derived fragments (tRFs) and tRNA halfs (tiRNAs). tsRNAs can affect cell functions by participating in gene e…
View article: A One-Bath Strategy Replace of Conventional Beamhouse on Dispase from Bacillus Subtilis for Eco-Sustainable Leather Processing
A One-Bath Strategy Replace of Conventional Beamhouse on Dispase from Bacillus Subtilis for Eco-Sustainable Leather Processing Open
View article: Hydrothermal synthesis and electrochemical properties of Sn-based peanut shell biochar electrode materials
Hydrothermal synthesis and electrochemical properties of Sn-based peanut shell biochar electrode materials Open
Using activated-carbon-based electrodes derived from waste biomass in super-capacitor energy technologies is an essential future strategy to achieve sustainable energy and environmental protection.
View article: Fatigue Behavior and Mechanism Study on Lugs of TC18 Titanium Alloy
Fatigue Behavior and Mechanism Study on Lugs of TC18 Titanium Alloy Open
Aerospace structural components are in a complex stress state when they undertake load due to their specific geometric construction. Their fatigue behavior is quite different from the materials that undertake the standard stress state. The…
View article: Effect of Artificial Liver Support Systems on Gut Microbiota in Patients with HBV-Related Acute-on-Chronic Liver Failure
Effect of Artificial Liver Support Systems on Gut Microbiota in Patients with HBV-Related Acute-on-Chronic Liver Failure Open
Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is a rare and severe form of end-stage liver disease with high mortality; gut microbes are strongly associated with the development of this severe liver disease but the ex…
View article: Schiff base crosslinked graphene/oxidized nanofibrillated cellulose/chitosan foam: An efficient strategy for selective removal of anionic dyes
Schiff base crosslinked graphene/oxidized nanofibrillated cellulose/chitosan foam: An efficient strategy for selective removal of anionic dyes Open
View article: Cre-loxP-mediated genetic lineage tracing: Unraveling cell fate and origin in the developing heart
Cre-loxP-mediated genetic lineage tracing: Unraveling cell fate and origin in the developing heart Open
The Cre-loxP-mediated genetic lineage tracing system is essential for constructing the fate mapping of single-cell progeny or cell populations. Understanding the structural hierarchy of cardiac progenitor cells facilitates unraveling cell …
View article: Research on the Application of Online and Offline Mixed Teaching Mode of Marketing Course Based on the BOPPPS Model
Research on the Application of Online and Offline Mixed Teaching Mode of Marketing Course Based on the BOPPPS Model Open
BOPPPS teaching fully integrates the advantages of online self-study and offline courses. This kind of teaching has been widely used in college education, and has proved to have a positive effect on improving students’ ability to solve pro…
View article: MicroRNA-485-3p Promotes the Inflammatory Response and Extracellular Matrix Deposition by Activating Wnt/β-Catenin Signaling in Human Airway Smooth Muscle Cells
MicroRNA-485-3p Promotes the Inflammatory Response and Extracellular Matrix Deposition by Activating Wnt/β-Catenin Signaling in Human Airway Smooth Muscle Cells Open
The aim of this study was to study the effects of microRNA (miR)-485-3p on the inflammatory response and extracellular matrix deposition of human airway smooth muscle cells (HASMCs). The levels of miR-485-3p and WIF1 in peripheral blood of…
View article: Mechanical Properties and Microstructural Evolution of Cansas-Iii Sic Fibers after Thermal Exposure in Different Atmospheres
Mechanical Properties and Microstructural Evolution of Cansas-Iii Sic Fibers after Thermal Exposure in Different Atmospheres Open
View article: Analysis and calculation of sediment scouring rate at different locations of storm sewer
Analysis and calculation of sediment scouring rate at different locations of storm sewer Open
To explore the migration differences of sediments at the front, middle, and end sections of a storm sewer when scoured by water, and further evaluate the pollution load, the scouring process of sediments at different locations of a storm s…
View article: Dexamethasone promotes the endoplasmic reticulum stress response of bone marrow mesenchymal stem cells by activating the PERK‐Nrf2 signaling pathway
Dexamethasone promotes the endoplasmic reticulum stress response of bone marrow mesenchymal stem cells by activating the PERK‐Nrf2 signaling pathway Open
The pathogenesis of steroid‐induced avascular necrosis of femoral head (SANFH) is complex, and there is a lack of effective early prevention method. The aim of the present study was to evaluate the effect of dexamethasone (DEX) on the biol…
View article: Circular RNAs act as regulators of autophagy in cancer
Circular RNAs act as regulators of autophagy in cancer Open
View article: Impact of the Gut Microbiome on the Progression of Hepatitis B Virus Related Acute-on-Chronic Liver Failure
Impact of the Gut Microbiome on the Progression of Hepatitis B Virus Related Acute-on-Chronic Liver Failure Open
The relationship between the progression of hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) and the gut microbiota is poorly understood, and an HBV-ACLF-related microbiome has yet to be identified. In this study alterat…
View article: Regulation of K+ Conductance by a Hydrogen Bond in Kv2.1, Kv2.2, and Kv1.2 Channels
Regulation of K+ Conductance by a Hydrogen Bond in Kv2.1, Kv2.2, and Kv1.2 Channels Open
The slow inactivation of voltage-gated potassium (Kv) channels plays an important role in controlling cellular excitability. Recently, the two hydrogen bonds (H-bonds) formed by W434-D447 and T439-Y445 have been reported to control the slo…
View article: Knockdown of 91 H Suppresses the Tumorigenesis of Osteosarcoma via Inducing Methylation of CDK4 Promoter
Knockdown of 91 H Suppresses the Tumorigenesis of Osteosarcoma via Inducing Methylation of CDK4 Promoter Open
Background: Osteosarcoma is the most leading primary malignancy of the bone in adolescents all over the world. Long non-coding RNA (lncRNA) 91 H has been reported to participated in multiple cancers. Meanwhile, lncRNA 91 H has been proved …
View article: The Emerging Roles of Autophagy-Related MicroRNAs in Cancer
The Emerging Roles of Autophagy-Related MicroRNAs in Cancer Open
Autophagy is a conserved catabolic process involving the degradation and recycling of damaged biomacromolecules or organelles through lysosomal-dependent pathways and plays a crucial role in maintaining cell homeostasis. Consequently, abno…
View article: Experiment and fitting calculation of migration critical velocity of small-sized sediment particles erosion in rainwater pipeline
Experiment and fitting calculation of migration critical velocity of small-sized sediment particles erosion in rainwater pipeline Open
The migration critical velocity of small-sized sediment particles was investigated through experiments under different particle sizes, pipe wall roughness, and sediment thickness. Such experiments were carried out to simulate the erosion p…
View article: Stepwise Ethanol-Water Fractionation of Enzymatic Hydrolysis Lignin to Improve Its Performance as a Cationic Dye Adsorbent
Stepwise Ethanol-Water Fractionation of Enzymatic Hydrolysis Lignin to Improve Its Performance as a Cationic Dye Adsorbent Open
In this work, lignin fractionation is proposed as an effective approach to reduce the heterogeneity of lignin and improve the adsorption and recycle performances of lignin as a cationic dye adsorbent. By stepwise dissolution of enzymatic h…
View article: lncRNA SNHG7 sponges miR‐425 to promote proliferation, migration, and invasion of hepatic carcinoma cells via Wnt/β‐catenin/EMT signalling pathway
lncRNA SNHG7 sponges miR‐425 to promote proliferation, migration, and invasion of hepatic carcinoma cells via Wnt/β‐catenin/EMT signalling pathway Open
Increasing evidence has indicated the important roles of long noncoding RNA small nucleolar RNA host gene 7 (SNHG7) in tumourigenesis as a potential oncogene. However, the function of SNHG7 in hepatic carcinoma remains unclear. In the pres…
View article: Identification of Extrachromosomal Linear microDNAs Interacted with microRNAs in the Cell Nuclei
Identification of Extrachromosomal Linear microDNAs Interacted with microRNAs in the Cell Nuclei Open
Extrachromosomal DNA exists in two forms: Covalently closed circular and linear. While diverse types of circular extrachromosomal DNA have been identified with validated in vivo functions, little is known about linear extrachromosomal DNA.…
View article: Reactive Oxygen Species Related Noncoding RNAs as Regulators of Cardiovascular Diseases
Reactive Oxygen Species Related Noncoding RNAs as Regulators of Cardiovascular Diseases Open
Reactive oxygen species (ROS) are a class of reactive molecules that have been implicated in a variety of cardiovascular diseases, accompanied by disorder of multiple signaling events. As cardiomyocytes maintain abundant of mitochondria, w…
View article: Flavone-based natural product agents as new lysine-specific demethylase 1 inhibitors exhibiting cytotoxicity against breast cancer cells in vitro
Flavone-based natural product agents as new lysine-specific demethylase 1 inhibitors exhibiting cytotoxicity against breast cancer cells in vitro Open
View article: Prostaglandin E2 increases migration and proliferation of human glioblastoma cells by activating transient receptor potential melastatin 7 channels
Prostaglandin E2 increases migration and proliferation of human glioblastoma cells by activating transient receptor potential melastatin 7 channels Open
Recent studies showed that both prostaglandin E2 ( PGE 2) and transient receptor potential melastatin 7 ( TRPM 7) play important roles in migration and proliferation of human glioblastoma cells. In this study, we tested the association bet…
View article: Graphene Oxide Reinforced Alginate/PVA Double Network Hydrogels for Efficient Dye Removal
Graphene Oxide Reinforced Alginate/PVA Double Network Hydrogels for Efficient Dye Removal Open
Dually crosslinked graphene oxide reinforced alginate/polyvinyl alcohol (PVA) double network (DN) hydrogels were prepared via a facile freeze/thaw method followed by soaking in a Ca2+ solution. The morphology and structure of the hydrogels…
View article: Synthesis and Characterization of Ampholytic Flocculant CPCTS-g-P (CTA-DMDAAC) and Its Flocculation Properties for Microcystis Aeruginosa Removal
Synthesis and Characterization of Ampholytic Flocculant CPCTS-g-P (CTA-DMDAAC) and Its Flocculation Properties for Microcystis Aeruginosa Removal Open
The ampholytic chitosan based flocculant carboxylated chitosan graft-(3-chloro-2-hydroxypropyl) trimethylammonium chloride-dimethyl diallyl ammonium chloride (CPCTS-g-P (CTA-DMDAAC)) was synthesized by photo polymerization using carboxylat…