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View article: An Exploration of the Antioxidative and Anti-Inflammatory Role of Lactiplantibacillus plantarum 106 via Improving Mitochondrial Function
An Exploration of the Antioxidative and Anti-Inflammatory Role of Lactiplantibacillus plantarum 106 via Improving Mitochondrial Function Open
In this present study, bioinformatics analysis and the experimental validation method were used to systematically explore the antioxidant activity and anti-inflammatory effect of Lactiplantibacillus plantarum A106, which was isolated from …
View article: HB-EGF induces mitochondrial dysfunction via estrogen hypersecretion in granulosa cells dependent on cAMP-PKA-JNK/ERK-Ca<sup>2+</sup>-FOXO1 pathway
HB-EGF induces mitochondrial dysfunction via estrogen hypersecretion in granulosa cells dependent on cAMP-PKA-JNK/ERK-Ca<sup>2+</sup>-FOXO1 pathway Open
Polycystic ovarian syndrome (PCOS) is one of the most prevalent endocrinopathies and the leading cause of anovulatory infertility, but its pathogenesis remains elusive. Although HB-EGF is involved in ovarian cancer progression, there is st…
View article: Malic enzyme 1 is important for uterine decidualization in response to progesterone/cAMP/PKA/HB‐EGF pathway
Malic enzyme 1 is important for uterine decidualization in response to progesterone/cAMP/PKA/HB‐EGF pathway Open
Malic enzyme 1 (Me1), a member of the malic enzymes involving in glycolytic pathway and citric acid cycle, is essential for the energy metabolism and maintenance of intracellular redox balance state, but its physiological role and regulato…
View article: HB-EGF Ameliorates Oxidative Stress-Mediated Uterine Decidualization Damage
HB-EGF Ameliorates Oxidative Stress-Mediated Uterine Decidualization Damage Open
HB-EGF is essential for uterine decidualization, but its antioxidant function remains largely unclear. Here, we found that HB-EGF promoted the proliferation of stromal cells followed by the accelerated transition of the cell cycle from G1 …
Additional file 3: of Lactobacillus plantarum C88 protects against aflatoxin B1-induced liver injury in mice via inhibition of NF-ÎşBâ mediated inflammatory responses and excessive apoptosis Open
The raw datas of Bax, Bcl-2 and Caspase-3 in liver. (XLSX 13 kb)
Additional file 1: of Lactobacillus plantarum C88 protects against aflatoxin B1-induced liver injury in mice via inhibition of NF-ÎşBâ mediated inflammatory responses and excessive apoptosis Open
The raw datas of biochemical parameters in serum, include ALT, AST, ALP, total cholesterol, triglycerides, total protein and albumin. (XLSX 14 kb)
Additional file 2: of Lactobacillus plantarum C88 protects against aflatoxin B1-induced liver injury in mice via inhibition of NF-κB–mediated inflammatory responses and excessive apoptosis Open
The raw datas of IL-1β, IL-6, IL-8, IL-10, IFN-γ, and TNF-α in serum. (XLSX 15 kb)
Reduction of Aflatoxin B1 Toxicity by Lactobacillus plantarum C88: A Potential Probiotic Strain Isolated from Chinese Traditional Fermented Food “Tofu” Open
In this study, we investigated the potential of Lactobacillus plantarum isolated from Chinese traditional fermented foods to reduce the toxicity of aflatoxin B1 (AFB1), and its subsequent detoxification mechanism. Among all the investigate…
View article: IGF1 regulates RUNX1 expression via IRS1/2: Implications for antler chondrocyte differentiation
IGF1 regulates RUNX1 expression via IRS1/2: Implications for antler chondrocyte differentiation Open
Although IGF1 is important for the proliferation and differentiation of chondrocytes, its underlying molecular mechanism is still unknown. Here we addressed the physiologic function of IGF1 in antler cartilage and explored the interplay of…
Genome shuffling of <i>Lactobacillus plantarum</i> C88 improves adhesion Open
Genome shuffling is an important method for rapid improvement in microbial strains for desired phenotypes. In this study, ultraviolet irradiation and nitrosoguanidine were used as mutagens to enhance the adhesion of the wild-type Lactobaci…
View article: Hmgn5 functions downstream of Hoxa10 to regulate uterine decidualization in mice
Hmgn5 functions downstream of Hoxa10 to regulate uterine decidualization in mice Open
Although Hmgn5 is involved in the regulation of cellular proliferation and differentiation, its physiological function during decidualization is still unknown. Here we showed that Hmgn5 was highly expressed in the decidual cells. Silencing…
View article: Hmgn5 functions downstream of Hoxa10 to regulate uterine decidualization in mice
Hmgn5 functions downstream of Hoxa10 to regulate uterine decidualization in mice Open
Although Hmgn5 is involved in the regulation of cellular proliferation and differentiation, its physiological function during decidualization is still unknown. Here we showed that Hmgn5 was highly expressed in the decidual cells. Silencing…
Genome shuffling of <i>Lactobacillus plantarum</i> C88 improves adhesion Open
Genome shuffling is an important method for rapid improvement in microbial strains for desired phenotypes. In this study, ultraviolet irradiation and nitrosoguanidine were used as mutagens to enhance the adhesion of the wild-type Lactobaci…