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View article: Novel Quaternary Ammonium Salt‐Linked STING Agonist Antibody‐Drug Conjugate: Synergistic Activation of Tumor Immunity with Mitigated Off‐Target Toxicity
Novel Quaternary Ammonium Salt‐Linked STING Agonist Antibody‐Drug Conjugate: Synergistic Activation of Tumor Immunity with Mitigated Off‐Target Toxicity Open
Immune‐stimulating antibody conjugate (ISACs) incorporating STING agonists as payloads leverage both the targeting capability of the Fab region and the Fc region‐mediated tumor antigen‐dependent immune activation. Herein, a novel class of …
View article: Daurisoline Modulates the TBK1-Dependent Type I Interferon Pathway to Boost Anti-tumor Immunity via Targeting of LRP1
Daurisoline Modulates the TBK1-Dependent Type I Interferon Pathway to Boost Anti-tumor Immunity via Targeting of LRP1 Open
A promising therapeutic approach in oncology involves immune checkpoint blockade (ICB), which stimulates anti-tumor immune responses. Nevertheless, the effectiveness of this treatment in clinical settings remains limited, underscoring the …
View article: Lactobacillus delbrueckii subsp. bulgaricus 1.0207 Exopolysaccharides Attenuate Hydrogen Peroxide-Induced Oxidative Stress Damage in IPEC-J2 Cells through the Keap1/Nrf2 Pathway
Lactobacillus delbrueckii subsp. bulgaricus 1.0207 Exopolysaccharides Attenuate Hydrogen Peroxide-Induced Oxidative Stress Damage in IPEC-J2 Cells through the Keap1/Nrf2 Pathway Open
Lactobacillus delbrueckii subsp. bulgaricus (L. bulgaricus) is one of the most commonly employed Lactobacillus in the food industry. Exopolysaccharides (EPS) of Lactobacillus, which are known to exhibit probiotic properties, are secondary …
View article: Investigation on chemically modified carbon black in enhancing asphalt performance
Investigation on chemically modified carbon black in enhancing asphalt performance Open
Asphalt is still regarded as the most common raw material for road paving. In the pursuit of more long-term sustainability and the creation of durable and resilient pavements, researchers are diligently exploring high-quality asphalt. The …
View article: The study on the conductivity of TCNQ-modified 2D conjugated metal sulfur-dilute nanosheets
The study on the conductivity of TCNQ-modified 2D conjugated metal sulfur-dilute nanosheets Open
Metal-organic frame materials are an important classification of new materials in metal-organic materials, and it is also the most popular area of research. Since the constituent bonds of the metal-organic framework are that the metal ions…
View article: Citrate-Assisted One-Pot Hydrothermal Preparation of Carbonated Hydroxyapatite Microspheres
Citrate-Assisted One-Pot Hydrothermal Preparation of Carbonated Hydroxyapatite Microspheres Open
Carbonated hydroxyapatite (CHA) microspheres have aroused wide concern in biofields because of their excellent biological and surface properties. However, the facile preparation of CHA microspheres from organic compounds, especially the mi…
View article: Raddeanin A Enhances Mitochondrial DNA‐cGAS/STING Axis‐Mediated Antitumor Immunity by Targeting Transactive Responsive DNA‐Binding Protein 43
Raddeanin A Enhances Mitochondrial DNA‐cGAS/STING Axis‐Mediated Antitumor Immunity by Targeting Transactive Responsive DNA‐Binding Protein 43 Open
Immune checkpoint therapies (ICT) have achieved unprecedented efficacy in multiple cancer treatments, but are still limited by low clinical response rates. Identification of immunogenic cell death (ICD)‐inducing drugs that can induce tumor…
View article: Preparation and Characterization of Hydroxyapatite Nanotubes
Preparation and Characterization of Hydroxyapatite Nanotubes Open
As the key mineral component of human bones, hydroxyapatite (HA) has grasped much attention due to its outstanding biocompatibility, bioactivity and osteoconductive properties. Among different morphologies of HA materials, the special stru…
View article: Effects of Graphite Particle Content and Holding Time on the Microstructure and Mechanical Properties of the Graphite/AZ91D Composite
Effects of Graphite Particle Content and Holding Time on the Microstructure and Mechanical Properties of the Graphite/AZ91D Composite Open
The effects of Grp (graphite particles) addition and holding time on the microstructure and mechanical properties of the Grp/AZ91D composite were investigated in this work. The results indicated that the distribution of Grp in the matrix w…
View article: Effects of Alkali Stress on the Growth and Menaquinone-7 Metabolism of Bacillus subtilis natto
Effects of Alkali Stress on the Growth and Menaquinone-7 Metabolism of Bacillus subtilis natto Open
Menaquinone-7 (MK-7) is an important vitamin K 2 , synthesized from the menaquinone parent ring and seven isoprene side chains. Presently, the synthesis of MK-7 stimulated by environmental stress primarily focuses on oxygen stress, while t…
View article: Co<sub>2</sub>O<sub>3</sub>/Co<sub>2</sub>N<sub>0.67</sub> nanoparticles encased in honeycomb-like N, P, O-codoped carbon framework derived from corncob as efficient ORR electrocatalysts
Co<sub>2</sub>O<sub>3</sub>/Co<sub>2</sub>N<sub>0.67</sub> nanoparticles encased in honeycomb-like N, P, O-codoped carbon framework derived from corncob as efficient ORR electrocatalysts Open
We develop a honey-comb-like N, P-codoped carbon framework derived from corncob as efficient ORR electrocatalysts.
View article: New Technique for Detecting Cracked Teeth and Evaluating the Crack Depth by Contrast-enhanced Cone Beam Computed Tomography: an in Vitro Study
New Technique for Detecting Cracked Teeth and Evaluating the Crack Depth by Contrast-enhanced Cone Beam Computed Tomography: an in Vitro Study Open
Background: Develop a new technique based on contrast-enhanced cone beam computed tomography (CBCT) to improve the detection of cracked teeth and the accuracy of crack depth evaluation in vitro. Methods: We developed an in vitro artificial…
View article: Hybrid van der Waals heterojunction based on two-dimensional materials
Hybrid van der Waals heterojunction based on two-dimensional materials Open
Since the discovery of graphene, two-dimensional (2D) layered materials have always been the focus of material research. The layers of 2D materials are covalent bonds, and the layers are weakly bonded to adjacent layers through van der Waa…
View article: Effect of F Functional Modification on the Stability and Electronic Structure of Borene
Effect of F Functional Modification on the Stability and Electronic Structure of Borene Open
Since the discovery of graphene, two-dimensional materials have quickly won widespread attention in the academic community. Borene is a two-dimensional isomer of boron and the lightest element Dirac material. It becomes the latest and prom…
View article: One-Dimensional Bimetallic Lantern Complex
One-Dimensional Bimetallic Lantern Complex Open
As the scale of microelectronic circuit devices approaches the atomic limit, the study of molecular-based wires and magnets has become more prevalent. Lantern (or paddle-wheel) complexes with conventional {O(S),O} donor building block came…
View article: Antiaging Property and Mechanism of Phase‐Change Asphalt with PEG as an Additive
Antiaging Property and Mechanism of Phase‐Change Asphalt with PEG as an Additive Open
In this study, phase‐change asphalt was prepared with polyethylene glycol (PEG‐1000) as a modifier. The short‐ and long‐term antiaging performances were characterized by rolling‐thin‐film‐oven (RTFOT) and pressure‐aging vessel (PAV) tests,…
View article: Transport and Photoelectric Properties of 2D Silicene/MX<sub>2</sub> (M = Mo, W; X = S, Se) Heterostructures
Transport and Photoelectric Properties of 2D Silicene/MX<sub>2</sub> (M = Mo, W; X = S, Se) Heterostructures Open
The transport and photoelectric properties of four two-dimensional (2D) silicene/MX2 (M = Mo, W; X = S, Se) heterostructures have been investigated by employing density functional theory, nonequilibrium Green's function, and Keldysh nonequ…
View article: Tunable transport and optoelectronic properties of monolayer black phosphorus by grafting PdCl<sub>2</sub>quantum dots
Tunable transport and optoelectronic properties of monolayer black phosphorus by grafting PdCl<sub>2</sub>quantum dots Open
The photoelectric properties of the coordination functionalized monolayer black phosphorus by PdCl2quantum dots are revealed for the first time.