Cuifen Hou
YOU?
Author Swipe
View article: 6-Benzhydryl-4-amino-quinolin-2-ones as Potent Cannabinoid Type 1 (CB<sub>1</sub>) Receptor Inverse Agonists and Chemical Modifications for Peripheral Selectivity
6-Benzhydryl-4-amino-quinolin-2-ones as Potent Cannabinoid Type 1 (CB<sub>1</sub>) Receptor Inverse Agonists and Chemical Modifications for Peripheral Selectivity Open
A novel series of 6-benzhydryl-4-amino-quinolin-2-ones was discovered as cannabinoid type 1 receptor (CB1R) inverse agonists based on the high-throughput screening hit, compound 1a. Structure-activity relationships were studied to improve …
Discovery of Orally Efficacious Tetrahydrobenzimidazoles as TGR5 Agonists for Type 2 Diabetes Open
We have discovered a novel series of tetrahydrobenzimidazoles 3 as TGR5 agonists. Initial structure-activity relationship studies with an assay that measured cAMP levels in murine enteroendocrine cells (STC-1 cells) led to the discovery of…