Cuifeng Li
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TNF inhibitors target a mevalonate metabolite/TRPM2/calcium signaling axis in neutrophils to dampen vasculitis in Behçet’s disease Open
TNF inhibitors have been used to treat autoimmune and autoinflammatory diseases. Here we report an unexpected mechanism underlying the therapeutic effects of TNF inhibitors in Behçet's disease (BD), an autoimmune inflammatory disorder. Usi…
Engineering Education Understanding Expert Decision System Research and Application Open
Engineering education is based on technical science and aims at training engineers who can transform science and technology into productive forces. In recent years, due to the emergence of new technology revolution, engineering science and…
View article: Bcl-3 promotes TNF-induced hepatocyte apoptosis by regulating the deubiquitination of RIP1
Bcl-3 promotes TNF-induced hepatocyte apoptosis by regulating the deubiquitination of RIP1 Open
Tumor necrosis factor-α (TNF) is described as a main regulator of cell survival and apoptosis in multiple types of cells, including hepatocytes. Dysregulation in TNF-induced apoptosis is associated with many autoimmune diseases and various…
Serum RelB is correlated with renal fibrosis and predicts chronic kidney disease progression Open
Dear Editor, Chronic kidney disease (CKD) with characteristics of progressive deterioration of renal function is regarded as one major public health problem around the world. The patients are often diagnosed at advanced stages with most ki…
Bcl-3 promotes Wnt signaling by maintaining the acetylation of β-catenin at lysine 49 in colorectal cancer Open
Wnt/β-catenin signaling plays a critical role in colorectal cancer (CRC) tumorigenesis and the homeostasis of colorectal cancer stem cells (CSCs), but its molecular mechanism remains unclear. B-cell lymphoma 3 (Bcl-3), a member of the IκB …
Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses Open
Trace elements play important roles in human health, but little is known about their functions in humoral immunity. Here, we show an important role for iron in inducing cyclin E and B cell proliferation. We find that iron-deficient individ…
Elevating H3K27me3 level sensitizes colorectal cancer to oxaliplatin Open
Histone methylation is a context-dependent modification that regulates gene expression, and the trimethylation of histone H3 lysine 27 (H3K27me3) usually induces gene silencing. Overcoming colorectal cancer (CRC) chemoresistance is current…
miR-449a inhibits colorectal cancer progression by targeting SATB2 Open
miR-449a has been reported to act as a tumor suppressor in several cancers, however, it is controversial whether it inhibits tumor growth in colorectal cancer. The mechanisms underlying its expression and functions in colorectal cancers ar…