Cuifeng Ying
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View article: Tracking single-molecule ferritin reassembly and disassembly using polymer-coated nanopores
Tracking single-molecule ferritin reassembly and disassembly using polymer-coated nanopores Open
This study uses polymer-coated SiN x nanopores and individual-event data analysis to track real time volume and shape changes of ferritin fragments during reassembly and disassembly, offering a powerful method for probing dynamic protein p…
View article: Probing protein surface interactions in nanoaperture optical tweezers
Probing protein surface interactions in nanoaperture optical tweezers Open
Nanoaperture optical tweezers (NOTs) can trap single proteins using local electromagnetic field enhancements at metal surfaces and therefore they are also subject to surface interactions. To probe these interactions, we consider the power …
View article: Reversible Thermal Tuning of High‐Q Non‐Local Lithium Niobate Metasurfaces
Reversible Thermal Tuning of High‐Q Non‐Local Lithium Niobate Metasurfaces Open
Dynamic control of optical resonances in metasurfaces has become increasingly critical, driven by the growing demand for tunable photonic devices across a wide range of modern nanophotonics applications, including optical switches, display…
View article: Dual-City Mirroring and Market Differentiation: Research on Price Correlations and Optimization Paths in Shanghai and Hong Kong Real Estate Markets
Dual-City Mirroring and Market Differentiation: Research on Price Correlations and Optimization Paths in Shanghai and Hong Kong Real Estate Markets Open
Existing studies have revealed the impact of policies, interest rates and other factors on the real estate market but focus on single-factor and single-region analyses, and there is a gap in the study of cross-regional multifactor influenc…
View article: Continuous, Low Latency Estimation of the Size and Shape of Single Proteins from Real-Time Nanopore Data
Continuous, Low Latency Estimation of the Size and Shape of Single Proteins from Real-Time Nanopore Data Open
Existing approaches for nanopore sensing typically analyze resistive pulses from the translocation of individual proteins through the nanopore after completing the experiment. This approach foregoes instantaneous protein identification and…
View article: Direct observation of conformational dynamics in intrinsically disordered proteins at the single-molecule level
Direct observation of conformational dynamics in intrinsically disordered proteins at the single-molecule level Open
Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) in structured proteins are integral to many biological processes including neurotransmitter regulation, microtubule regulation, and transcription. IDP/IDR…
View article: Error mitigated metasurface-based randomized measurement schemes
Error mitigated metasurface-based randomized measurement schemes Open
Estimating properties of quantum states via randomized measurements has become a significant part of quantum information science. In this paper, we design an innovative approach leveraging metasurfaces to perform randomized measurements on…
View article: Energy Landscape of Conformational Changes for a Single Unmodified Protein
Energy Landscape of Conformational Changes for a Single Unmodified Protein Open
Free-energy landscapes govern protein biophysics and natural conformational changes linked to function can be described by trajectories on these landscapes. Resolving the free energy landscape is obscured by ensemble averaging. A direct me…
View article: Tunable Ion Conductivity in Defect‐Controlled Graphene Nanochannels
Tunable Ion Conductivity in Defect‐Controlled Graphene Nanochannels Open
Many novel transport phenomena are observed in graphene nanochannels with ultrahigh surface flatness and nano‐ or sub‐nanoscale constraints. Two critical physical parameters, surface slip length, and surface charge, play a vital role in th…
View article: Structural Flexibility and Disassembly Kinetics of Single Ferritin Molecules Using Optical Nanotweezers
Structural Flexibility and Disassembly Kinetics of Single Ferritin Molecules Using Optical Nanotweezers Open
Ferritin, a spherical protein shell assembled from 24 subunits, functions as an efficient iron storage and release system through its channels. Understanding how various chemicals affect the structural behavior of ferritin is crucial for u…
View article: Infrared imaging with nonlinear silicon resonator governed by high-Q quasi-BIC states
Infrared imaging with nonlinear silicon resonator governed by high-Q quasi-BIC states Open
Nonlinear light-matter interactions have emerged as a promising platform for various applications, including imaging, nanolasing, background-free sensing, etc. Subwavelength dielectric resonators offer unique opportunities for manipulating…
View article: Resolving multiple conformations of a sub-80 kDa Chagas vaccine candidate by cryo-EM led integrative approach
Resolving multiple conformations of a sub-80 kDa Chagas vaccine candidate by cryo-EM led integrative approach Open
Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, remains a significant global public health concern. Despite its profound health impact in both endemic and non-endemic areas, no vaccine is available, and the existing the…
View article: Cryo-EM led analysis of open and closed conformations of Chagas vaccine candidate TcPOP and its antibody response characterisation
Cryo-EM led analysis of open and closed conformations of Chagas vaccine candidate TcPOP and its antibody response characterisation Open
Chagas disease, caused by the protozoan parasite Trypanosoma cruzi , remains a significant global public health concern. Despite its profound health impact in both endemic and non-endemic areas, no vaccine is available, and the existing th…
View article: Optical scattering methods for the label-free analysis of single biomolecules
Optical scattering methods for the label-free analysis of single biomolecules Open
Single-molecule techniques to analyze proteins and other biomolecules involving labels and tethers have allowed for new understanding of the underlying biophysics; however, the impact of perturbation from the labels and tethers has recentl…
View article: Label-Free Tracking of Proteins through Plasmon-Enhanced Interference
Label-Free Tracking of Proteins through Plasmon-Enhanced Interference Open
Single unmodified biomolecules in solution can be observed and characterized by interferometric imaging approaches; however, Rayleigh scattering limits this to larger proteins (typically >30 kDa). We observe real-time image tracking of unm…
View article: Advances in nonlinear metasurfaces for imaging, quantum, and sensing applications
Advances in nonlinear metasurfaces for imaging, quantum, and sensing applications Open
Metasurfaces, composed of artificial meta-atoms of subwavelength size, can support strong light–matter interaction based on multipolar resonances and plasmonics, hence offering the great capability of empowering nonlinear generation. Recen…
View article: Structural Flexibility and Disassembly Kinetics of Single Ferritins Using Optical Nanotweezers
Structural Flexibility and Disassembly Kinetics of Single Ferritins Using Optical Nanotweezers Open
Ferritin, a spherical protein shell assembled from 24 subunits, functions as an efficient iron storage and release system through its channels. Understanding how various chemicals affect the structural behaviour of ferritin is crucial for …
View article: Error Mitigated Metasurface-Based Randomized Measurement Schemes
Error Mitigated Metasurface-Based Randomized Measurement Schemes Open
Estimating properties of quantum states via randomized measurements has become a significant part of quantum information science. In this paper, we design an innovative approach leveraging metasurfaces to perform randomized measurements on…
View article: Simultaneous Determination of the Size and Shape of Single α-Synuclein Oligomers in Solution
Simultaneous Determination of the Size and Shape of Single α-Synuclein Oligomers in Solution Open
Soluble oligomers of amyloid-forming proteins are implicated as toxic species in the context of several neurodegenerative diseases. Since the size and shape of these oligomers influence their toxicity, their biophysical characterization is…
View article: Optical Monitoring of <i>In Situ</i> Iron Loading into Single, Native Ferritin Proteins
Optical Monitoring of <i>In Situ</i> Iron Loading into Single, Native Ferritin Proteins Open
Ferritin is a protein that stores and releases iron to prevent diseases associated with iron dysregulation in plants, animals, and bacteria. The conversion between iron-loaded holo-ferritin and empty apo-ferritin is an important process fo…
View article: Smart wearable triboelectric nanogenerator for self-powered bioelectronics and therapeutics
Smart wearable triboelectric nanogenerator for self-powered bioelectronics and therapeutics Open
With the development of Triboelectric Nanogenerators (TENGs), the field of energy harvesting has experienced a new era of revolution following the trend to configure innovative materials, design, integrated sensing and high triboelectric o…
View article: Simultaneous Determination of the Size and Shape of Single α-Synuclein Oligomers in Solution
Simultaneous Determination of the Size and Shape of Single α-Synuclein Oligomers in Solution Open
Soluble oligomers of amyloid-forming proteins are implicated as toxic species in the context of several neurodegenerative diseases. Since the size and shape of these oligomers influences their toxicity, their biophysical characterization i…
View article: Third-harmonic generation and imaging with resonant Si membrane metasurface
Third-harmonic generation and imaging with resonant Si membrane metasurface Open
Dielectric metasurfaces play an increasingly important role in enhancing optical nonlinear generations owing to their abil-ity to support strong light-matter interactions based on Mie-type multipolar resonances. Compared to metasurfaces co…
View article: Localized Nanopore Fabrication via Controlled Breakdown
Localized Nanopore Fabrication via Controlled Breakdown Open
Nanopore sensors provide a unique platform to detect individual nucleic acids, proteins, and other biomolecules without the need for fluorescent labeling or chemical modifications. Solid-state nanopores offer the potential to integrate nan…
View article: Boosted second-harmonic generation in the LiNbO$\mathrm{_3}$ metasurface governed by high-Q guided resonances and bound states in the continuum
Boosted second-harmonic generation in the LiNbO$\mathrm{_3}$ metasurface governed by high-Q guided resonances and bound states in the continuum Open
To date, second-harmonic generation (SHG) at nanoscale has been concentrated on employing high-refractive-index nanostructures, owing to the strong field confinement at deep subwavelength scales based on optically resonant effects. However…
View article: Effects of off-axis translocation through nanopores on the determination of shape and volume estimates for individual particles
Effects of off-axis translocation through nanopores on the determination of shape and volume estimates for individual particles Open
Resistive pulses generated by nanoparticles that translocate through a nanopore contain multi-parametric information about the physical properties of those particles. For example, non-spherical particles sample several different orientatio…
View article: Enhanced four-wave mixing from multi-resonant silicon dimer-hole membrane metasurfaces
Enhanced four-wave mixing from multi-resonant silicon dimer-hole membrane metasurfaces Open
Tailoring optically resonant features in dielectric metasurfaces unveils a robust scheme to control electromagnetic near fields of light and thus to boost the nanoscale nonlinear light–matter interactions. Membrane metasurfaces offer uniqu…