Cuige Shi
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View article: Lycium barbarum polysaccharide ameliorates corticosterone-induced cognition decline with modulation of CRHR1
Lycium barbarum polysaccharide ameliorates corticosterone-induced cognition decline with modulation of CRHR1 Open
This study demonstrates that LBP ameliorated CORT-induced cognition decline by regulating CRHR1. Therefore, LBP may represent a potential drug for the prevention of cognition dysfunction in patients caused by increased GCs.
Genome-wide analysis of methylation in rat fetal heart under hyperglycemia by methylation-dependent restriction site–associated DNA sequencing Open
Diabetes mellitus causes an increased incidence of congenital heart malformations. However, the pathogenesis and potential epigenetic mechanism involved in this process are unclear. In this study, we used MethylRAD sequencing to compare ch…
A Factor Analysis Model for Rapid Evaluation of the Semen Quality of Fertile Men in China Open
Ning Wang,1 Meifang Song,2 Haike Gu,2 Yiyuan Gao,1 Ge Yu,3 Fang Lv,4 Cuige Shi,5 Shangming Wang,5 Liwen Sun,1 Yang Xiao,6 Shucheng Zhang1 1Department of Health Quality Center, National Research Institute for Family Planning, Beijing, Peopl…
Study on Influencing Factors of Semen Quality in Fertile Men Open
Objective To establish a system for evaluation of semen quality in fertile men by factor analysis (FA). Methods The FA method was used to analyze five sperm test indicators for fertile men (sperm pH, sperm motility, sperm progressive motil…
View article: What Is the Impact of Excessive Iodine and Semen Quality in Fertile Men of China: An Association Study 
What Is the Impact of Excessive Iodine and Semen Quality in Fertile Men of China: An Association Study Open
Background: Iodine is an essential element for hormones synthesized by the human thyroid gland. Thyroid hormone deficiency affects all body tissues, including multiple endocrine changes that alter growth hormones, corticotrophin, glucocort…
What is The Impact of Excessive Iodine and Semen Quality in Fertile Men of China: An Association Study Open
Background: Iodine is an essential element for hormones synthesized by the human thyroid gland. Thyroid hormone deficiency affects all body tissues, including multiple endocrine changes that alter growth hormones, corticotrophin, glucocort…
Elevated MST1 leads to apoptosis via depletion of YAP1 in cardiomyocytes exposed to high glucose Open
Background Gestational diabetes mellitus is a risk factor for congenital heart defects. The article aimed to investigate the expression and roles of MST1, YAP1, Last1/2 and Survivin in modulating HG-induced cardiomyocyte apoptosis and mate…
High-expression of ROCK1 modulates the apoptosis of lens epithelial cells in age-related cataracts by targeting p53 gene Open
Background Age-related cataract (ARC) is a serious visual impairment disease, and its pathogenesis is unclear. This article aims to investigate the role of ROCK1 in the apoptosis of lens epithelial cells (LECs) in age-related cataracts. Me…
High-expression of ROCK1 modulates the apoptosis of lens epithelial cells in age-related cataracts by targeting p53 gene Open
Background: Age-related cataract (ARC) is a serious visual impairment disease, and its pathogenesis is unclear. This article aims to investigate the role of ROCK1 in the apoptosis of lens epithelial cells (LECs) in age-related cataracts. M…
Abnormal Expression of MST1 and YAP1 in Fetal Heart Tissue in a Hyperglycemic Environment and Their Roles in Mediating Apoptosis Open
Background： Gestational diabetes mellitus is a risk factor for congenital heart defects. The article aimed to investigate the expression and roles of Mst1, Yap1, Last1/2 and Survivin in modulating HG-induced cardiomyocyte apoptosis and mat…
High-Expression of ROCK1 Modulates the Apoptosis of Lens Epithelial Cells in Age-Related Cataracts by Targeting p53 Gene Open
Background: Age-related cataract (ARC) is a serious visual impairment disease, and its pathogenesis is unclear. This article aims to investigate the role of ROCK1 in the apoptosis of lens epithelial cells (LECs) in age-related cataracts. M…
Pentraxin 3, TNF-α, and LDL-C Are Associated With Carotid Artery Stenosis in Patients With Ischemic Stroke Open
Background: Carotid artery stenosis (CAS), typically resulting from atherosclerotic progression, is more common than intracranial atherosclerotic disease in patients with cerebrovascular disease. Prior literature has incompletely establish…
View article: NPY Receptor 2 Mediates NPY Antidepressant Effect in the mPFC of LPS Rat by Suppressing NLRP3 Signaling Pathway
NPY Receptor 2 Mediates NPY Antidepressant Effect in the mPFC of LPS Rat by Suppressing NLRP3 Signaling Pathway Open
Accumulated evidences show that neuroinflammation play a pivotal role in the pathogenesis of depression. Neuropeptide Y (NPY) and its receptors have been demonstrated to have anti-inflammative as well as antidepressant effects. In the pres…
Inhibition of GALR1 in PFC Alleviates Depressive-Like Behaviors in Postpartum Depression Rat Model by Upregulating CREB-BNDF and 5-HT Levels Open
Estrogen (E2) withdrawal is a core pathology mechanism for postpartum depression (PPD). Galanin (GAL), an estrogen-inducible neuropeptide has also been reported to be associated with depression. However, it still remains unclear which GAL …
Repeated abortion in adulthood induces cognition impairment in aged mice Open
Age-related cognitive decline is one of the major aspects that impede successful aging in humans. Repeated abortion in adulthood can accelerate or aggravate cognitive deficiency during aging. Here we used repeated abortion in female mice a…
Involvement of retinoblastoma-associated protein 48 during photodynamic therapy of cervical cancer cells Open
5-Aminolevulinic acid-mediated photodynamic therapy (ALA‑PDT) is an effective treatment option for cervical intraepithelial neoplasia, the precancerous lesion of cervical cancer, and early cervical cancer, particularly for young or nullipa…
Effects of ALA-PDT on HPV16-immortalized cervical epithelial cell Open
Current treatments for high-grade cervical intraepithelial neoplasia (CIN) and persistent infection with high-risk human papillomavirus (HR-HPV) type are mainly surgical interventions. However, such treatments are associated with adverse s…
Paeoniflorin attenuates hippocampal damage in a rat model of vascular dementia Open
Paeoniflorn (PF), the principal bioactive component of Paeoniae radix prescribed in traditional Chinese medicine, possesses a wide range of biological effects and exhibits neuroprotective effects in numerous diseases. Previous studies have…