Cuiling Zhong
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View article: Supplementary Figure 1 from Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12
Supplementary Figure 1 from Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12 Open
PDF file, 869K, Proliferation and apoptosis analysis by IF staining in EL4 tumor sections.
View article: Supplementary Figure 2 from Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12
Supplementary Figure 2 from Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12 Open
PDF file, 20K, Effects of 30D8 on 4T1 cell migration in vitro.
View article: Supplementary Figure 4 from Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12
Supplementary Figure 4 from Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12 Open
PDF file, 38K, Sequence alignment of 30D8 and humanized 30D8 (hu30D8).
View article: Data from Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12
Data from Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12 Open
Purpose: Our goal was to develop a potent humanized antibody against mouse/human CXCL12. This report summarized its in vitro and in vivo activities.Experimental Design: Cell surface binding and cell migration as…
View article: Supplementary Figure 5 from Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12
Supplementary Figure 5 from Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12 Open
PDF file, 28K, Effects of 30D8 on CXCL12 and VEGF serum levels in HM7 tumor bearing mice.
View article: Supplementary Figure 6 from Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12
Supplementary Figure 6 from Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12 Open
PDF file, 26K, Comparison of PK in Balb c/nude mice of three hamster antibodies with similar binding affinity toward human CXCL12.
View article: Supplementary Figure 3 from Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12
Supplementary Figure 3 from Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12 Open
PDF file, 239K, Intervention studies in the laser-induced choroidal neovascularization (CNV) model.
View article: Supplementary Figure 4 from Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12
Supplementary Figure 4 from Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12 Open
PDF file, 38K, Sequence alignment of 30D8 and humanized 30D8 (hu30D8).
View article: Supplementary Methods from Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12
Supplementary Methods from Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12 Open
PDF file, 138K
View article: Supplementary Methods from Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12
Supplementary Methods from Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12 Open
PDF file, 138K
View article: Data from Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12
Data from Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12 Open
Purpose: Our goal was to develop a potent humanized antibody against mouse/human CXCL12. This report summarized its in vitro and in vivo activities.Experimental Design: Cell surface binding and cell migration as…
View article: Supplementary Figure Legends from Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12
Supplementary Figure Legends from Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12 Open
PDF file, 78K
View article: Supplementary Figure Legends from Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12
Supplementary Figure Legends from Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12 Open
PDF file, 78K
View article: Supplementary Figure 6 from Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12
Supplementary Figure 6 from Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12 Open
PDF file, 26K, Comparison of PK in Balb c/nude mice of three hamster antibodies with similar binding affinity toward human CXCL12.
View article: Supplementary Figure 3 from Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12
Supplementary Figure 3 from Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12 Open
PDF file, 239K, Intervention studies in the laser-induced choroidal neovascularization (CNV) model.
View article: Supplementary Figure 1 from Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12
Supplementary Figure 1 from Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12 Open
PDF file, 869K, Proliferation and apoptosis analysis by IF staining in EL4 tumor sections.
View article: Supplementary Figure 5 from Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12
Supplementary Figure 5 from Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12 Open
PDF file, 28K, Effects of 30D8 on CXCL12 and VEGF serum levels in HM7 tumor bearing mice.
View article: Supplementary Figure 2 from Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12
Supplementary Figure 2 from Development and Preclinical Characterization of a Humanized Antibody Targeting CXCL12 Open
PDF file, 20K, Effects of 30D8 on 4T1 cell migration in vitro.
View article: Heparin-binding VEGFR1 variants as long-acting VEGF inhibitors for treatment of intraocular neovascular disorders
Heparin-binding VEGFR1 variants as long-acting VEGF inhibitors for treatment of intraocular neovascular disorders Open
Significance Vascular endothelial growth factor (VEGF) inhibitors have transformed the treatment of intraocular vascular disorders. However, the burden of frequent intravitreal injections reduces patient compliance such that the impact in …
View article: Inhibition of protein glycosylation is a novel pro-angiogenic strategy that acts via activation of stress pathways
Inhibition of protein glycosylation is a novel pro-angiogenic strategy that acts via activation of stress pathways Open
Endothelial cell (EC) metabolism is thought to be one of the driving forces for angiogenesis. Here we report the identification of the hexosamine D-mannosamine (ManN) as an EC mitogen and survival factor for bovine and human microvascular …
View article: Rho-stimulated Contractility Contributes to the Fibroblastic Phenotype of Ras-transformed Epithelial Cells
Rho-stimulated Contractility Contributes to the Fibroblastic Phenotype of Ras-transformed Epithelial Cells Open
Oncogenic transformation of cells alters their morphology, cytoskeletal organization, and adhesive interactions. When the mammary epithelial cell line MCF10A is transformed by activated H-Ras, the cells display a mesenchymal/fibroblastic m…
View article: Rho-mediated Contractility Exposes a Cryptic Site in Fibronectin and Induces Fibronectin Matrix Assembly
Rho-mediated Contractility Exposes a Cryptic Site in Fibronectin and Induces Fibronectin Matrix Assembly Open
Many factors influence the assembly of fibronectin into an insoluble fibrillar extracellular matrix. Previous work demonstrated that one component in serum that promotes the assembly of fibronectin is lysophosphatidic acid (Zhang, Q., W.J.…
View article: Suppressing neutrophil-dependent angiogenesis abrogates resistance to anti-VEGF antibody in a genetic model of colorectal cancer
Suppressing neutrophil-dependent angiogenesis abrogates resistance to anti-VEGF antibody in a genetic model of colorectal cancer Open
Significance Using mouse models that recapitulate key genetic abnormalities accumulating during colorectal cancer (CRC) tumorigenesis, we report that chemically induced colitis promoted development of colon tumors that were largely resista…
View article: Evidence for Pro-angiogenic Functions of VEGF-Ax
Evidence for Pro-angiogenic Functions of VEGF-Ax Open