Cuimei Xu
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View article: The dependence of CO2 cerebrovascular reactivity (CVR) on caffeine
The dependence of CO2 cerebrovascular reactivity (CVR) on caffeine Open
Cerebrovascular reactivity (CVR) represents an important marker of brain vascular health, particularly in the context of small and large vessel diseases. However, an undesired feature of this measure is that there exist large variations in…
View article: Cerebrovascular reactivity (CVR) MRI as a biomarker for cerebral small vessel disease (SVD) related cognitive decline: Multi‐site validation in the MarkVCID Consortium
Cerebrovascular reactivity (CVR) MRI as a biomarker for cerebral small vessel disease (SVD) related cognitive decline: Multi‐site validation in the MarkVCID Consortium Open
Background Cerebral small vessel disease (SVD) related vascular contributions represent a major factor contributing to cognitive decline and dementia (VCID) in older adults. However, there has not been a validated biomarker for the diagnos…
View article: Cerebrovascular reactivity (CVR) MRI as a biomarker for cerebral small vessel disease (SVD) related cognitive decline: Multi‐site validation in the MarkVCID Consortium
Cerebrovascular reactivity (CVR) MRI as a biomarker for cerebral small vessel disease (SVD) related cognitive decline: Multi‐site validation in the MarkVCID Consortium Open
Background Cerebral small vessel disease (SVD) related vascular contributions represent a major factor contributing to cognitive decline and dementia (VCID) in older adults. However, there has not been a validated biomarker for the diagnos…
View article: Amphetamine Derivatives as Potent Central Nervous System Multitarget SERT/NET/H3 Agents: Synthesis and Biological Evaluation
Amphetamine Derivatives as Potent Central Nervous System Multitarget SERT/NET/H3 Agents: Synthesis and Biological Evaluation Open
In this research, a variety of novel amphetamine derivatives were synthesized and assessed for their potential as multifaceted antidepressant agents. Among these compounds, compound 11b demonstrated potent inhibitory effects on both seroto…
View article: Cerebrovascular reactivity MRI as a biomarker for cerebral small vessel disease–related cognitive decline: Multi‐site validation in the MarkVCID Consortium
Cerebrovascular reactivity MRI as a biomarker for cerebral small vessel disease–related cognitive decline: Multi‐site validation in the MarkVCID Consortium Open
INTRODUCTION Vascular contributions to cognitive impairment and dementia (VCID) represent a major factor in cognitive decline in older adults. The present study examined the relationship between cerebrovascular reactivity (CVR) measured by…
View article: Evaluating cerebrovascular reactivity measured by velocity selective inversion arterial spin labeling with different post‐labeling delays: The effect of fast flow
Evaluating cerebrovascular reactivity measured by velocity selective inversion arterial spin labeling with different post‐labeling delays: The effect of fast flow Open
Purpose Velocity selective arterial spin labeling (VSASL) quantification assumes that the labeled bolus continuously moves into the imaging voxel during the post‐labeling delay (PLD). Faster blood flow could lead to a bolus duration shorte…
View article: Brain Frontal-Lobe Misery Perfusion in COVID-19 ICU Survivors: An MRI Pilot Study
Brain Frontal-Lobe Misery Perfusion in COVID-19 ICU Survivors: An MRI Pilot Study Open
Post-acute COVID-19 syndrome (PCS) is highly prevalent. Critically ill patients requiring intensive care unit (ICU) admission are at a higher risk of developing PCS. The mechanisms underlying PCS are still under investigation and may invol…
View article: Blood-brain barrier breakdown in COVID-19 ICU survivors: an MRI pilot study
Blood-brain barrier breakdown in COVID-19 ICU survivors: an MRI pilot study Open
Objectives Coronavirus disease 2019 (COVID-19) results in severe inflammation at the acute stage. Chronic neuroinflammation and abnormal immunological response have been suggested to be the contributors to neuro-long-COVID, but direct evid…
View article: Dependence of resting-state-based cerebrovascular reactivity (CVR) mapping on spatial resolution
Dependence of resting-state-based cerebrovascular reactivity (CVR) mapping on spatial resolution Open
Cerebrovascular reactivity (CVR) is typically assessed with a carbon dioxide (CO 2 ) stimulus combined with BOLD fMRI. Recently, resting-state (RS) BOLD fMRI has been shown capable of generating CVR maps, providing a potential for broader …
View article: Altered linear coupling between stimulus-evoked blood flow and oxygen metabolism in the aging human brain
Altered linear coupling between stimulus-evoked blood flow and oxygen metabolism in the aging human brain Open
Neural-vascular coupling (NVC) is the process by which oxygen and nutrients are delivered to metabolically active neurons by blood vessels. Murine models of NVC disruption have revealed its critical role in healthy neural function. We hypo…
View article: CO2 cerebrovascular reactivity measured with phase‐contrast MRI: A potential biomarker of cognition and physical function in older adults
CO2 cerebrovascular reactivity measured with phase‐contrast MRI: A potential biomarker of cognition and physical function in older adults Open
Background Vascular cognitive decline is a prominent cause of late‐life cognitive impairment. Compared to Alzheimer’s disease(AD), there is a paucity of biomarkers for its diagnosis, stratification, and treatment monitoring. Cerebrovascula…
View article: Quantitative Cerebrovascular Reactivity in Normal Aging: Comparison Between Phase-Contrast and Arterial Spin Labeling MRI
Quantitative Cerebrovascular Reactivity in Normal Aging: Comparison Between Phase-Contrast and Arterial Spin Labeling MRI Open
Purpose: Cerebrovascular reactivity (CVR) is an index of the dilatory function of cerebral blood vessels and has shown great promise in the diagnosis of risk factors in cerebrovascular disease. Aging is one such risk factor; thus, it is im…
View article: Association of cerebrovascular reactivity and Alzheimer pathologic markers with cognitive performance
Association of cerebrovascular reactivity and Alzheimer pathologic markers with cognitive performance Open
This study provides Class II evidence that CVR was significantly associated with cognitive performance independent of AD pathology.
View article: Brain Oxygen Extraction Is Differentially Altered by Alzheimer's and Vascular Diseases
Brain Oxygen Extraction Is Differentially Altered by Alzheimer's and Vascular Diseases Open
Background Alzheimer's disease and vascular cognitive impairment (VCI), as well as their concurrence, represent the most common types of cognitive dysfunction. Treatment strategies for these two conditions are quite different; however, the…
View article: Normal variations in brain oxygen extraction fraction are partly attributed to differences in end-tidal CO<sub>2</sub>
Normal variations in brain oxygen extraction fraction are partly attributed to differences in end-tidal CO<sub>2</sub> Open
Cerebral oxygen extraction fraction is an important physiological index of the brain’s oxygen consumption and supply and has been suggested to be a potential biomarker for a number of diseases such as stroke, Alzheimer’s disease, multiple …