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View article: A Machine Learning-Based Quality Control Algorithm for Heavy Rainfall Using Multi-Source Data
A Machine Learning-Based Quality Control Algorithm for Heavy Rainfall Using Multi-Source Data Open
In this study, a machine learning-based quality control algorithm for heavy rainfall was developed by integrating automatic weather station observations with remote sensing data, minute-level data, and metadata. Based on heavy rainfall sam…
View article: Online-Coupled Aerosol Effects on Cloud Microphysics and Surface Solar Irradiance in WRF-Solar
Online-Coupled Aerosol Effects on Cloud Microphysics and Surface Solar Irradiance in WRF-Solar Open
The online coupling of aerosols and clouds and its effect on surface global horizontal irradiance (GHI) has not yet been thoroughly investigated in the Weather Research and Forecasting Model with Solar extensions (WRF-Solar), despite its p…
View article: Lipidomics reveals potential biomarkers and pathophysiological insights in the progression of diabetic kidney disease
Lipidomics reveals potential biomarkers and pathophysiological insights in the progression of diabetic kidney disease Open
This study deciphers the lipid signature in DKD progression, and suggests the Lipid9-SCB panel as a promising tool for early DKD detection in DM patients.
View article: Development of cyclopeptide inhibitors specifically disrupting FXR–coactivator interaction in the intestine as a novel therapeutic strategy for MASH
Development of cyclopeptide inhibitors specifically disrupting FXR–coactivator interaction in the intestine as a novel therapeutic strategy for MASH Open
Intestinal farnesoid X receptor (FXR) antagonists have been proven to be efficacious in ameliorating metabolic diseases, particularly for the treatment of metabolic dysfunction-associated steatohepatitis (MASH). All the reported FXR antago…
View article: Variations in Gut Microbiome Profiles Based on Different DNA Extraction Methods: A Comparative Study
Variations in Gut Microbiome Profiles Based on Different DNA Extraction Methods: A Comparative Study Open
Objectives. To compare four DNA extraction methods for recovering bacterial DNA from mammalian faecal samples. Methods and Results. Three commercial kits from QIAamp, TIANamp, and MAGEN, together with the classic cetyltrimethylammonium bro…
View article: Correction: Limosilactobacillus reuteri and caffeoylquinic acid synergistically promote adipose browning and ameliorate obesity-associated disorders
Correction: Limosilactobacillus reuteri and caffeoylquinic acid synergistically promote adipose browning and ameliorate obesity-associated disorders Open
View article: TasselLFANet: a novel lightweight multi-branch feature aggregation neural network for high-throughput image-based maize tassels detection and counting
TasselLFANet: a novel lightweight multi-branch feature aggregation neural network for high-throughput image-based maize tassels detection and counting Open
Accurately and rapidly counting the number of maize tassels is critical for maize breeding, management, and monitoring the growth stage of maize plants. With the advent of high-throughput phenotyping platforms and the availability of large…
View article: Limosilactobacillus reuteri and caffeoylquinic acid synergistically promote adipose browning and ameliorate obesity-associated disorders
Limosilactobacillus reuteri and caffeoylquinic acid synergistically promote adipose browning and ameliorate obesity-associated disorders Open
Objective High intake of caffeoylquinic acid (CQA)-rich dietary supplements, such as green coffee bean extracts, offers health-promoting effects on maintaining metabolic homeostasis. Similar to many active herbal ingredients with high phar…
View article: Improving Clear-Sky Solar Power Prediction over China by Assimilating Himawari-8 Aerosol Optical Depth with WRF-Chem-Solar
Improving Clear-Sky Solar Power Prediction over China by Assimilating Himawari-8 Aerosol Optical Depth with WRF-Chem-Solar Open
Although the Weather Research and Forecasting model with solar extensions (WRF-Solar) is tailed for solar energy applications, its official version lacks the consideration of the online aerosol-radiation process. To overcome this limitatio…
View article: Discovery of Betulinic Acid Derivatives as Potent Intestinal Farnesoid X Receptor Antagonists to Ameliorate Nonalcoholic Steatohepatitis
Discovery of Betulinic Acid Derivatives as Potent Intestinal Farnesoid X Receptor Antagonists to Ameliorate Nonalcoholic Steatohepatitis Open
Farnesoid X receptor (FXR) has emerged as a promising therapeutic target for nonalcoholic steatohepatitis (NASH) because of its tightly interwoven relationship with bile acid homeostasis, inflammation, fibrosis, and glucose and lipid metab…
View article: AtCaM4 interacts with a Sec14-like protein, PATL1, to regulate freezing tolerance in Arabidopsis in a CBF-independent manner
AtCaM4 interacts with a Sec14-like protein, PATL1, to regulate freezing tolerance in Arabidopsis in a CBF-independent manner Open
Calmodulin (CaM), a multifunctional Ca2+ sensor, mediates multiple reactions involved in regulation of plant growth and responses to environmental stress. In this study, we found that AtCaM4 plays a negative role in freezing tolerance in A…