Cuiping Fu
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View article: Tumor-associated Tn and STn antigens: from molecular mechanism to precision diagnosis and treatment
Tumor-associated Tn and STn antigens: from molecular mechanism to precision diagnosis and treatment Open
Background Abnormal protein glycosylation is a key feature of tumors. Among the modifications, Tn antigen (GalNAcα1-Ser/Thr) and its sialylated derivative, STn antigen (Neu5Acα2-6GalNAcα1-O-Ser/Thr), are prominent tumor-associated carbohyd…
View article: Postoperative microcystic meningioma of the fourth ventricle with subsequent giant cell reparative granuloma: a case report
Postoperative microcystic meningioma of the fourth ventricle with subsequent giant cell reparative granuloma: a case report Open
Background Microcystic meningioma (MM) is a distinctive benign tumor typically located in the supratentorial region. Giant cell reparative granuloma (GCRG) is another rare reactive benign lesion associated with surgical trauma or tissue in…
View article: Combined Effect of 12 Weeks Baduanjin and Tri-Ball Respiratory Training as a Home-Based Pulmonary Rehabilitation in Subjects With Moderate Chronic Obstructive Pulmonary Disease: A Multi-Center Randomized Controlled Trial
Combined Effect of 12 Weeks Baduanjin and Tri-Ball Respiratory Training as a Home-Based Pulmonary Rehabilitation in Subjects With Moderate Chronic Obstructive Pulmonary Disease: A Multi-Center Randomized Controlled Trial Open
Background Despite promising individual benefits, the combined efficacy of Baduanjin and Tri-Ball Breath training as a home-based pulmonary rehabilitation in Chronic Obstructive Pulmonary Disease (COPD) subjects remains unexplored. Objecti…
View article: Development and validation of an interpretable machine learning model for predicting the risk of hepatocellular carcinoma in patients with chronic hepatitis B: a case-control study
Development and validation of an interpretable machine learning model for predicting the risk of hepatocellular carcinoma in patients with chronic hepatitis B: a case-control study Open
ML models can be used as a tool to predict the risk of HCC in patients with CHB. The RF model has the best predictive performance and helps clinicians to identify high-risk patients and intervene early to reduce or delay the occurrence of …
View article: Atypical rat bite fever associated with knee joint infection in a Chinese patient: a case report
Atypical rat bite fever associated with knee joint infection in a Chinese patient: a case report Open
In atypical cases, importantly, clinical healthcare professionals should promptly obtain microbiological culture results. When culture is negative, 16S ribosomal RNA gene polymerase chain reaction (16S rRNA PCR) or mNGS can be considered f…
View article: [Activation of ALDH2 alleviates hypoxic pulmonary hypertension in mice by upregulating the SIRT1/PGC-1α signaling pathway].
[Activation of ALDH2 alleviates hypoxic pulmonary hypertension in mice by upregulating the SIRT1/PGC-1α signaling pathway]. Open
ALDH2 alleviates hypoxiainduced senescence of pulmonary artery smooth muscle cells by upregulating the SIRT1/PGC-1α signaling pathway to alleviate pulmonary hypertension in mice.
View article: Clinical Response Predictive Model for Omalizumab in Moderate-to-Severe Asthma Patients
Clinical Response Predictive Model for Omalizumab in Moderate-to-Severe Asthma Patients Open
Objective. Our study aimed to develop a predictive model for evaluating the clinical response of omalizumab treatment in moderate-to-severe asthma patients. Methods. This single-center, prospective study collected patients who meet the dia…
View article: Effect of Baduanjin on pulmonary rehabilitation outcomes in patients with moderate chronic obstructive pulmonary disease: a multi-center randomized controlled trial
Effect of Baduanjin on pulmonary rehabilitation outcomes in patients with moderate chronic obstructive pulmonary disease: a multi-center randomized controlled trial Open
Background: Effect of Baduanjin, as a traditional Chinese mindful movement, on patients with moderate chronic obstructive pulmonary disease (COPD), was still unknown. The aim of our study was to evaluate its efficiency on pulmonary functio…
View article: Effect of Baduanjin on pulmonary rehablitation in patients with moderate chronic obstructive pulmonary disease: a multi-center randomized controlled trial (Preprint)
Effect of Baduanjin on pulmonary rehablitation in patients with moderate chronic obstructive pulmonary disease: a multi-center randomized controlled trial (Preprint) Open
BACKGROUND Baduanjin has been applied in health and rehabilitation and gained a growing number of practitioners both in home and abroad.To explore the effect of home based and video guided PR training, our research determined to evaluate …
View article: The effect of Tai Chi on the pulmonary rehabilitation of chronic obstructive pulmonary disease: a systematic review and meta-analysis
The effect of Tai Chi on the pulmonary rehabilitation of chronic obstructive pulmonary disease: a systematic review and meta-analysis Open
Tai Chi may have the potential to reduce dyspnoea, enhance exercise capacity, and improve the quality of life in COPD patients. People with COPD may obtain benefit from practicing Tai Chi.
View article: The effect of coagulation factors in 2019 novel coronavirus patients
The effect of coagulation factors in 2019 novel coronavirus patients Open
Background: The role of coagulation dysfunction in Severe Coronavirus Disease 2019 (COVID-19) is inconsistent. We aimed to explore the impact of coagulation dysfunction amongst patients with COVID-19. Methods: We searched PubMed, Cochrane …
View article: Clinical risk factors for mortality of hospitalized patients with COVID-19: systematic review and meta-analysis
Clinical risk factors for mortality of hospitalized patients with COVID-19: systematic review and meta-analysis Open
Male, current smoking patients aged 60 years or over might face a greater risk of in-hospital death and the comorbidities such as diabetes, hypertension, CVD, respiratory disease, and CKD could also influence the prognosis of the COVID-19.…
View article: Hyperchloremia is associated with aute kidney injury in critical ill patients: an analysis of the MIMIC-III database
Hyperchloremia is associated with aute kidney injury in critical ill patients: an analysis of the MIMIC-III database Open
Objective: Balanced fluid with no critical increase of chloride in serum was recommended in clinic. Whether hyperchloremia could make a difference for intensive care unit (ICU) patients with a higher acute kidney injury (AKI) occurrence re…
View article: SOD2 ameliorates pulmonary hypertension in a murine model of sleep apnea via suppressing expression of NLRP3 in CD11b+ cells
SOD2 ameliorates pulmonary hypertension in a murine model of sleep apnea via suppressing expression of NLRP3 in CD11b+ cells Open
Background High prevalence of obstructive sleep apnea (OSA) in the pulmonary hypertension (PH) population suggests that chronic intermittent hypoxia (CIH) is an important pathogenic factor of PH. However, the exact mechanism of CIH induced…
View article: Efficiency of High‐Flow Nasal Cannula on Pulmonary Rehabilitation in COPD Patients: A Meta‐Analysis
Efficiency of High‐Flow Nasal Cannula on Pulmonary Rehabilitation in COPD Patients: A Meta‐Analysis Open
Introduction . The clinical benefit of high‐flow nasal cannula (HFNC) on factors related to pulmonary rehabilitation in chronic obstructive pulmonary disease (COPD) patients remains unclear. This meta‐analysis aimed at synthesizing the ava…
View article: Activation of the IL-4/STAT6 Signaling Pathway Promotes Lung Cancer Progression by Increasing M2 Myeloid Cells
Activation of the IL-4/STAT6 Signaling Pathway Promotes Lung Cancer Progression by Increasing M2 Myeloid Cells Open
Emerging evidence shows that signal transducer and activator of transcription 6 (STAT6) plays critical roles in tumor development. We previously found high-level expression of STAT6 in human lung adenocarcinoma and squamous cell carcinoma,…
View article: Predictors of mid-term prognosis and adverse factors in acute pulmonary embolism
Predictors of mid-term prognosis and adverse factors in acute pulmonary embolism Open
Background: To explore the differences in short and middle term adverse factors of pulmonary embolism (PE) outcome. Methods: This was a single-center retrospective study of inpatients admitted from Zhongshan Hospital, Fudan University, wit…
View article: Screening for obstructive sleep apnea syndrome in asthma patients: a prospective study based on Berlin and STOP-Bang questionnaires
Screening for obstructive sleep apnea syndrome in asthma patients: a prospective study based on Berlin and STOP-Bang questionnaires Open
SBQ is a preferable sleep questionnaire better than BQ for detecting moderate and severe OSA in asthma patients which should be validated in larger population sample.
View article: iRGD-modified lipid–polymer hybrid nanoparticles loaded with isoliquiritigenin to enhance anti-breast cancer effect and tumor-targeting ability
iRGD-modified lipid–polymer hybrid nanoparticles loaded with isoliquiritigenin to enhance anti-breast cancer effect and tumor-targeting ability Open
Fei Gao,1–3 Jinming Zhang,3 Chaomei Fu,3 Xiaoming Xie,4 Fu Peng,1–3 Jieshu You,1,2 Hailin Tang,1,2,4 Zhiyu Wang,5 Peng Li,6 Jianping Chen1–3 1School of Chinese Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, …
View article: Lung injury and inflammation response by chronic intermittent hypoxia in rats
Lung injury and inflammation response by chronic intermittent hypoxia in rats Open
Chronic intermittent hypoxia is the primary pathophsiological feature of obstructive sleep apnea/hypopnea syndrome. The characteristics of CIH can be imitated by animal experiment models thus to study CIH related systemic organ injuries, i…
View article: Chronic intermittent hypoxia affects endogenous serotonergic inputs and expression of synaptic proteins in rat hypoglossal nucleus.
Chronic intermittent hypoxia affects endogenous serotonergic inputs and expression of synaptic proteins in rat hypoglossal nucleus. Open
Evidence has shown that hypoxic episodes elicit hypoglossal neuroplasticity which depends on elevated serotonin (5-HT), in contrast to the rationale of obstructive sleep apnea (OSA) that deficient serotonergic input to HMs fails to keep ai…
View article: G4-Tetra DNA Duplex Induce Lung Cancer Cell Apoptosis in A549 Cells
G4-Tetra DNA Duplex Induce Lung Cancer Cell Apoptosis in A549 Cells Open
The specific DNA is typically impermeable to the plasma membrane due to its natural characters, but DNA tetra structures (DTNs) can be readily uptake by cells in the absence of transfection agents, providing a new strategy to deliver DNA d…