Bo Huang
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View article: Study on Preparation and Properties of Phosphogypsum-Based Lightweight Thermal Insulation Materials
Study on Preparation and Properties of Phosphogypsum-Based Lightweight Thermal Insulation Materials Open
At present, phosphogypsum, as an industrial by-product, is a solid waste in phosphoric acid production, and its accumulation has caused serious environmental pollution. Furthermore, due to the insufficient insulation properties of traditio…
View article: Mechanistic insights into the effects of Tris-2-butoxyethyl phosphate on multiple cancers using network toxicology and molecular docking
Mechanistic insights into the effects of Tris-2-butoxyethyl phosphate on multiple cancers using network toxicology and molecular docking Open
This study investigates the potential mechanisms by which Tris(2-butoxyethyl) phosphate (TBEP) may contribute to the development and progression of human malignancies. Fourteen representative cancer types were selected to explore the molec…
View article: Reposition of lenalidomide as a radiation protector based on LINCS gene expression signatures and its preclinical validation
Reposition of lenalidomide as a radiation protector based on LINCS gene expression signatures and its preclinical validation Open
Ionizing radiation induces DNA damage and impairs genomic integrity, leading to cell death and tissue injuries or carcinogenesis. Medical radiation protectors are essential and necessary. However, there are limited radioprotectors in clini…
View article: Identification of Schizophrenia‐Risk Regulatory Variant rs1399178 in the Non‐coding Region With Its Impact on <scp>NRF1</scp> Binding
Identification of Schizophrenia‐Risk Regulatory Variant rs1399178 in the Non‐coding Region With Its Impact on <span>NRF1</span> Binding Open
Aims The challenges in identifying functional variants from genome‐wide association studies (GWAS) and unraveling regulatory mechanisms in schizophrenia research persist, particularly in intronic regions. A non‐coding regulatory variant, r…
View article: Amniotic fluid-derived exosomal miR-146a-5p ameliorates preeclampsia phenotypes by inhibiting HIF-1α/FLT-1 expression
Amniotic fluid-derived exosomal miR-146a-5p ameliorates preeclampsia phenotypes by inhibiting HIF-1α/FLT-1 expression Open
The study provided experimental evidence for the protective effects of normal AF-Exos on ameliorating preeclampsia phenotypes, and miR-146a-5p may act an important role in enhancing the proliferation and migration of trophoblast cells by t…
View article: TDP43 negatively regulates TBK1-mediated IFN1 production through IRF7 pathway in neurodegenerative diseases
TDP43 negatively regulates TBK1-mediated IFN1 production through IRF7 pathway in neurodegenerative diseases Open
Mutations in the genes encoding TAR DNA-binding protein 43 (TDP43) or TANK-binding kinase 1 (TBK1) have been strongly associated with neurological disorders, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. TDP43 …
View article: Research on Low-Latency TTP–TSN Cross-Domain Network Planning Problem
Research on Low-Latency TTP–TSN Cross-Domain Network Planning Problem Open
With services becoming increasingly complex and network scales expanding, hybrid network architectures that combine bus and switch networks while supporting deterministic transmission will play a crucial role in future networks. Time-Trigg…
View article: Harnessing P450 enzyme plasticity for generalizable peptide biaryl macrocyclization
Harnessing P450 enzyme plasticity for generalizable peptide biaryl macrocyclization Open
Macrocyclic peptides containing biaryl motifs, predominantly derived from natural products, are valuable scaffolds due to their structural rigidity and potent bioactivity. However, current synthetic methods remain constrained by the absenc…
View article: [Mechanism Research of lncRNA miR143HG on Regulating the Biological Behavior
of Lung Squamous Cell Carcinoma H520 Cells].
[Mechanism Research of lncRNA miR143HG on Regulating the Biological Behavior
of Lung Squamous Cell Carcinoma H520 Cells]. Open
LncRNA miR143HG was of great significance for the biological behavior of H520 cells. LncRNA miR143HG inhibited the ability of proliferation, migration, and invasion, as well as enhanced the apoptosis of H520 cells by downregulating miR-155…
View article: Knockdown of <scp>circADAM9</scp> inhibits cell progression and glycolysis by targeting the <scp>miR</scp>‐1236‐3p/<scp>FGF7</scp> axis in breast cancer
Knockdown of <span>circADAM9</span> inhibits cell progression and glycolysis by targeting the <span>miR</span>‐1236‐3p/<span>FGF7</span> axis in breast cancer Open
Background Circular RNAs (circRNAs) are closely associated with the development of breast cancer (BC). In this study, we aimed to clarify how differentially expressed circRNAs affect the development of BC. Methods Quantitative real‐time po…
View article: hUC-EVs-ATO reduce the severity of acute GVHD by resetting inflammatory macrophages toward the M2 phenotype
hUC-EVs-ATO reduce the severity of acute GVHD by resetting inflammatory macrophages toward the M2 phenotype Open
Background Both extracellular vesicles from mesenchymal stromal cell-derived human umbilical cords (hUC-EVs) and arsenic trioxides (ATOs) have been demonstrated to treat acute graft-versus-host disease (aGVHD) via immunomodulation. Apart f…
View article: Additional file 1 of CircARID1A binds to IGF2BP3 in gastric cancer and promotes cancer proliferation by forming a circARID1A-IGF2BP3-SLC7A5 RNA–protein ternary complex
Additional file 1 of CircARID1A binds to IGF2BP3 in gastric cancer and promotes cancer proliferation by forming a circARID1A-IGF2BP3-SLC7A5 RNA–protein ternary complex Open
Additional file 1: Table S1. Characteristics of GC patients for circARID1A measurement. Table S2. SiRNAs sequences. Table S3. Probes for RNA-FISH. Table S4. Primers for amplification of indicated genes. Table S5. Probes for RNA pull-down. …
View article: Silencing circSLC19A1 Inhibits Prostate Cancer Cell Proliferation, Migration and Invasion Through Regulating miR-326/MAPK1 Axis
Silencing circSLC19A1 Inhibits Prostate Cancer Cell Proliferation, Migration and Invasion Through Regulating miR-326/MAPK1 Axis Open
Banggao Huang,1 Danhong Zhou,2 Xinmian Huang,1 Xiaobo Xu,1 Zhihui Xu1 1Department of Urology, Zhejiang Provincial People’s Hospital, Hangzhou, Zhejiang Province, People’s Republic of China; 2Department of Surgery, The Third People’s Hospit…
View article: Tumor‐derived microparticles in tumor immunology and immunotherapy
Tumor‐derived microparticles in tumor immunology and immunotherapy Open
Microvesicles or microparticles, a type of cytoplasm membrane‐derived extracellular vesicles, can be released by cancer cells or normal cell types. Alteration of F‐actin cytoskeleton by various signals may lead to the cytoplasm membrane en…
View article: Comparison of whole exome sequencing in circulating tumor cells of primitive and metastatic nasopharyngeal carcinoma
Comparison of whole exome sequencing in circulating tumor cells of primitive and metastatic nasopharyngeal carcinoma Open
These changes are strongly relevant to their clinical characteristics and therapeutic strategy.
View article: Retraction Note: Cardamonin induces ROS-mediated G2/M phase arrest and apoptosis through inhibition of NF-κB pathway in nasopharyngeal carcinoma
Retraction Note: Cardamonin induces ROS-mediated G2/M phase arrest and apoptosis through inhibition of NF-κB pathway in nasopharyngeal carcinoma Open
The authors have retracted this article [1] because of numerous errors in the figures. Specifically:
View article: Circulating Tumor Microparticles Promote Lung Metastasis by Reprogramming Inflammatory and Mechanical Niches via a Macrophage-Dependent Pathway
Circulating Tumor Microparticles Promote Lung Metastasis by Reprogramming Inflammatory and Mechanical Niches via a Macrophage-Dependent Pathway Open
Despite the frequency of lung metastasis and its associated mortality, the mechanisms behind metastatic tumor cell survival and colonization in the lungs remain elusive. Here, we show that tumor cell–released microparticles (T-MPs) from th…
View article: Fibrin Stiffness Mediates Dormancy of Tumor-Repopulating Cells via a Cdc42-Driven Tet2 Epigenetic Program
Fibrin Stiffness Mediates Dormancy of Tumor-Repopulating Cells via a Cdc42-Driven Tet2 Epigenetic Program Open
Dormancy is recognized as a critical biological event for tumorigenic cells surviving in an extremely harsh environment. Understanding the molecular process of dormancy can unlock novel approaches to tackle cancers. We recently reported th…
View article: STAT3/p53 pathway activation disrupts IFN-β–induced dormancy in tumor-repopulating cells
STAT3/p53 pathway activation disrupts IFN-β–induced dormancy in tumor-repopulating cells Open
Dynamic interaction with the immune system profoundly regulates tumor cell dormancy. However, it is unclear how immunological cues trigger cancer cell-intrinsic signaling pathways for entering into dormancy. Here, we show that IFN-β treatm…
View article: CDC5L drives FAH expression to promote metabolic reprogramming in melanoma
CDC5L drives FAH expression to promote metabolic reprogramming in melanoma Open
Metabolic reprogramming allows tumor cells to thrive in the typically hypoxic tumor microenvironment. Using immunodetection and clinical data analyses, we demonstrate here that fumarylacetoacetate hydrolase (FAH) is highly expressed in mel…