Cuiqin Shi
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View article: Positive effect of deep diaphragmatic breathing training on gastroesophageal reflux-induced chronic cough: a clinical randomized controlled study
Positive effect of deep diaphragmatic breathing training on gastroesophageal reflux-induced chronic cough: a clinical randomized controlled study Open
Background and Objective To explore the efficacy of deep diaphragmatic breathing training (DEP) in patients with gastroesophageal reflux-induced chronic cough (GERC). Methods A randomized controlled study was conducted involving 60 GERC pa…
View article: The Efficacy and Safety of Duloxetine in Treating Refractory Chronic Cough: A Randomized Clinical Trial
The Efficacy and Safety of Duloxetine in Treating Refractory Chronic Cough: A Randomized Clinical Trial Open
View article: A comparison between a gastroesophageal reflux disease questionnaire-based algorithm and multichannel intraluminal impedance-pH monitoring for the treatment of gastroesophageal reflux-induced chronic cough
A comparison between a gastroesophageal reflux disease questionnaire-based algorithm and multichannel intraluminal impedance-pH monitoring for the treatment of gastroesophageal reflux-induced chronic cough Open
Background: Empiric therapy with multichannel intraluminal impedance-pH monitoring (MII-pH) has been used for the initial treatment of gastroesophageal reflux-induced chronic cough (GERC). However, an algorithm based on the gastroesophagea…
View article: A randomized, double-blinded, placebo-controlled clinical trial of duloxetine hydrochloride enteric-coated tablets in the treatment of refractory chronic cough
A randomized, double-blinded, placebo-controlled clinical trial of duloxetine hydrochloride enteric-coated tablets in the treatment of refractory chronic cough Open
View article: Mean Nocturnal Baseline Impedance (MNBI) Provides Evidence for Standardized Management Algorithms of Nonacid Gastroesophageal Reflux-Induced Chronic Cough
Mean Nocturnal Baseline Impedance (MNBI) Provides Evidence for Standardized Management Algorithms of Nonacid Gastroesophageal Reflux-Induced Chronic Cough Open
Background. The clinical management of nonacid gastroesophageal reflux-induced chronic cough (GERC) is challenging, and patient response to standard antireflux therapy (omeprazole 20 mg twice daily plus mosapride 10 mg thrice daily) is sub…
View article: Psychological morbidity and chronic cough: which is predominant? A comparison of clinical characteristics
Psychological morbidity and chronic cough: which is predominant? A comparison of clinical characteristics Open
Background: The clinical characteristics of chronic cough with pre-existing psychological co-morbidity (PCC) and chronic cough with secondary anxiety and depression (SCC) were compared to provide a basis for diagnosing and treating psychol…
View article: A comparative study on the value of lower airway exhaled nitric oxide combined with small airway parameters for diagnosing cough-variant asthma
A comparative study on the value of lower airway exhaled nitric oxide combined with small airway parameters for diagnosing cough-variant asthma Open
Background: The diagnosis of cough-variant asthma (CVA) is based on bronchial provocation test, which is challenging to be conducted. Most CVA patients have type 2 airway inflammation and small airway dysfunction. FeNO 200 , reflecting sma…
View article: A Study on Cough Sensitivity and Airway Inflammation in Patients with Sinobronchial Syndrome
A Study on Cough Sensitivity and Airway Inflammation in Patients with Sinobronchial Syndrome Open
Objective. This study aimed to clarify the characteristics of cough-reflex sensitivity and airway inflammation in patients with sinobronchial syndrome (SBS). Methods. 39 patients with SBS, 53 patients with upper airway cough syndrome (UACS…
View article: The efficacy of gabapentin for the treatment of refractory cough associated with interstitial lung disease: study protocol for a randomized, double-blind and placebo-controlled clinical trial
The efficacy of gabapentin for the treatment of refractory cough associated with interstitial lung disease: study protocol for a randomized, double-blind and placebo-controlled clinical trial Open
View article: Diagnostic value of reflux episodes in gastroesophageal reflux-induced chronic cough: a novel predictive indicator
Diagnostic value of reflux episodes in gastroesophageal reflux-induced chronic cough: a novel predictive indicator Open
Background: Multichannel intraluminal impedance and pH-monitoring (MII-pH) is an essential testing modality for gastroesophageal reflux-induced chronic cough (GERC), while the existing diagnostic criteria still have some inherent defects. …
View article: Cough hypersensitivity in patients with metabolic syndrome: a clinical finding and its possible mechanisms
Cough hypersensitivity in patients with metabolic syndrome: a clinical finding and its possible mechanisms Open
Purpose To investigate the changes of cough sensitivity in patients with metabolic syndrome and its possible mechanisms. Method A total of 29 metabolic syndrome (MetS) patients with OSAHS (group-1), 22 MetS patients without OSAHS (group-2)…
View article: Cough Hypersensitivity in Patients With Metabolic Syndrome: A Clinical Finding and Its Possible Mechanisms
Cough Hypersensitivity in Patients With Metabolic Syndrome: A Clinical Finding and Its Possible Mechanisms Open
Purpose : To investigate the changes of cough sensitivity in patients with metabolic syndrome and its possible mechanisms. Method : A total of 29 metabolic syndrome (MetS) patients with OSAHS (group-1), 22 MetS patients without OSAHS (grou…
View article: Can acid exposure time replace the DeMeester score in the diagnosis of gastroesophageal reflux-induced cough?
Can acid exposure time replace the DeMeester score in the diagnosis of gastroesophageal reflux-induced cough? Open
Background: The objective of this study was to compare the predictive accuracy of the acid exposure time (AET) with the DeMeester score (DMS) for gastroesophageal reflux–induced cough (GERC). Methods: A total of 277 patients who underwent …
View article: Sensitivity and specificity of combination of Hull airway reflux questionnaire and gastroesophageal reflux disease questionnaire in identifying patients with gastroesophageal reflux-induced chronic cough
Sensitivity and specificity of combination of Hull airway reflux questionnaire and gastroesophageal reflux disease questionnaire in identifying patients with gastroesophageal reflux-induced chronic cough Open
HARQ used to evaluate the cough hypersensitivity has a certain predictive diagnostic value for GERC. The diagnosis of GERC should be considered when the HARQ score is ≥24. The predictive diagnostic value of the combination of HARQ and Gerd…
View article: Drug-induced chronic cough and the possible mechanism of action
Drug-induced chronic cough and the possible mechanism of action Open
Chronic cough is defined as a cough lasting for ≥8 weeks with a normal chest radiograph. The common causes of chronic cough are cough variant asthma (CVA), upper airway cough syndrome/postnasal drip syndrome (UACS/PNDs), eosinophilic bronc…
View article: Reflux characteristics in patients with gastroesophageal reflux-related chronic cough complicated by laryngopharyngeal reflux
Reflux characteristics in patients with gastroesophageal reflux-related chronic cough complicated by laryngopharyngeal reflux Open
LPR overlaps with GERC in part. GERC patients with higher RSI scores may present more proximal reflux, non-acid reflux, and gas reflux, and get better efficacy with neuromodulators (gabapentin or baclofen) used as an add-on therapy.
View article: Changing etiological frequency of chronic cough in a tertiary hospital in Shanghai, China
Changing etiological frequency of chronic cough in a tertiary hospital in Shanghai, China Open
The etiological frequency of chronic cough varies over time, and it may encourage the adjustment of the current diagnostic and therapeutic strategies for chronic cough.
View article: Randomised clinical trial: gabapentin vs baclofen in the treatment of suspected refractory gastro‐oesophageal reflux‐induced chronic cough
Randomised clinical trial: gabapentin vs baclofen in the treatment of suspected refractory gastro‐oesophageal reflux‐induced chronic cough Open
Summary Background Neuromodulators are considered potential therapeutic options for refractory gastro‐oesophageal reflux‐induced chronic cough. Aim To compare the efficacy of gabapentin and baclofen in patients with suspected refractory ga…
View article: Association of cough hypersensitivity with tracheal TRPV1 activation and neurogenic inflammation in a novel guinea pig model of citric acid-induced chronic cough
Association of cough hypersensitivity with tracheal TRPV1 activation and neurogenic inflammation in a novel guinea pig model of citric acid-induced chronic cough Open
Objective This study was performed to establish a novel model of citric acid-induced chronic cough in guinea pigs and to investigate the pathogenesis of cough hypersensitivity. Methods Healthy conscious guinea pigs inhaled citric acid (0.4…
View article: Changes of serum TNF-α, IL-5 and IgE levels in the patients of mycoplasma pneumonia infection with or without bronchial asthma.
Changes of serum TNF-α, IL-5 and IgE levels in the patients of mycoplasma pneumonia infection with or without bronchial asthma. Open
Our findings indicate that serum levels of TNF-α, IL-5 and IgE may play important roles in the pathogenesis of MP infection, especially in asthma patients.