Cuiting Fang
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View article: The Identification of Novel Mutations in ATP-Dependent Protease ClpC1 Assists in the Molecular Diagnosis of Obscured Pyrazinamide-Resistant Tuberculosis Clinical Isolates
The Identification of Novel Mutations in ATP-Dependent Protease ClpC1 Assists in the Molecular Diagnosis of Obscured Pyrazinamide-Resistant Tuberculosis Clinical Isolates Open
Pyrazinamide (PZA) is a key component of tuberculosis treatment, with drug resistance (PZAR) primarily related to pncA mutations. However, discordance between phenotypic resistance and conventional pncA-based molecular diagnostics challeng…
View article: Dual Mutations in MSMEG_0965 and MSMEG_1380 Confer High-Level Resistance to Bortezomib and Linezolid by Both Reducing Drug Intake and Increasing Efflux in Mycobacterium smegmatis
Dual Mutations in MSMEG_0965 and MSMEG_1380 Confer High-Level Resistance to Bortezomib and Linezolid by Both Reducing Drug Intake and Increasing Efflux in Mycobacterium smegmatis Open
The emergence of multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis strains poses serious challenges to global tuberculosis control, highlighting the urgent need to elucidate the mechanisms underlying multidrug r…
View article: Structural Insights into Bortezomib-Induced Activation of the Caseinolytic Chaperone-Protease System in Mycobacterium tuberculosis
Structural Insights into Bortezomib-Induced Activation of the Caseinolytic Chaperone-Protease System in Mycobacterium tuberculosis Open
The caseinolytic protease (Clp) system has recently emerged as a promising anti-tuberculosis target. The anti-cancer drug bortezomib exhibits potent anti-mycobacterial activity and binds to Mycobacterium tuberculosis ( Mtb ) Clp protease c…
View article: A CRISPR‐nonhomologous end‐joining‐based strategy for rapid and efficient gene disruption in <i>Mycobacterium abscessus</i>
A CRISPR‐nonhomologous end‐joining‐based strategy for rapid and efficient gene disruption in <i>Mycobacterium abscessus</i> Open
Mycobacterium abscessus , a fast‐growing, non‐tuberculous mycobacterium resistant to most antimicrobial drugs, causes a wide range of serious infections in humans, posing a significant public health challenge. The development of effective …
View article: <b>The stress response factor SigH mediates intrinsic resistance to multiple antibiotics in <i>Mycobacterium abscessus</i></b>
<b>The stress response factor SigH mediates intrinsic resistance to multiple antibiotics in <i>Mycobacterium abscessus</i></b> Open
Mycobacterium abscessus (Mab) causes pulmonary diseases with limited treatment options due to its high level of intrinsic resistance to available drugs. Mab possesses complex and poorly understood drug resistance mechanisms. Identifying ne…
View article: Dual Mutations in MSMEG_0965 and MSMEG_1380 Confer High-Level Resistance to Bortezomib and Linezolid by Both Reducing Drug Intake and Increasing Efflux in <em>Mycobacterium smegmatis</em>
Dual Mutations in MSMEG_0965 and MSMEG_1380 Confer High-Level Resistance to Bortezomib and Linezolid by Both Reducing Drug Intake and Increasing Efflux in <em>Mycobacterium smegmatis</em> Open
The emergence of multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis strains poses serious challenges to global tuberculosis control, highlighting the urgent need to unravel the mechanisms underlying multidrug res…
View article: GrcC1 mediates low-level resistance to multiple drugs in <i>M. marinum</i> , <i>M. abscessus,</i> and <i>M. smegmatis</i>
GrcC1 mediates low-level resistance to multiple drugs in <i>M. marinum</i> , <i>M. abscessus,</i> and <i>M. smegmatis</i> Open
The escalating threat of mycobacterial infectious diseases, particularly those caused by nontuberculous mycobacteria (NTM), poses a serious challenge to public health. Linezolid (LZD), an oxazolidinone antimicrobial, exhibits potent activi…
View article: The gene <i>MAB_2362</i> is responsible for intrinsic resistance to various drugs and virulence in <i>Mycobacterium abscessus</i> by regulating cell division
The gene <i>MAB_2362</i> is responsible for intrinsic resistance to various drugs and virulence in <i>Mycobacterium abscessus</i> by regulating cell division Open
Mycobacterium abscessus exhibits intrinsic resistance to most antibiotics, hence leading to infections that are difficult to treat. To address this issue, the identification of new molecular targets is essential for the development or repo…
View article: EmbB and EmbC regulate the sensitivity of <i>Mycobacterium abscessus</i> to echinomycin
EmbB and EmbC regulate the sensitivity of <i>Mycobacterium abscessus</i> to echinomycin Open
Treatment of Mycobacterium abscessus (Mab) infections is very challenging due to its intrinsic resistance to most available drugs. Therefore, it is crucial to discover novel anti‐Mab drugs. In this study, we explored an intrinsic resistanc…
View article: Investigating the role of <i>MAB_1915</i> in intrinsic resistance to multiple drugs in <i>Mycobacterium abscessus</i>
Investigating the role of <i>MAB_1915</i> in intrinsic resistance to multiple drugs in <i>Mycobacterium abscessus</i> Open
The increasing clinical significance of Mycobacterium abscessus is owed to its innate high-level, broad-spectrum resistance to antibiotics and therefore rapidly evolves as an important human pathogen. This warrants the identification of no…
View article: MtrAB two-component system is crucial for the intrinsic resistance and virulence of<i>Mycobacterium abscessus</i>
MtrAB two-component system is crucial for the intrinsic resistance and virulence of<i>Mycobacterium abscessus</i> Open
Mycobacterium abscessus (Mab) poses serious therapeutic challenges, principally due to its intrinsic resistance to a wide array of antibiotics. The pressing issue of drug resistance has spurred an urgent need to explore novel targets and d…
View article: EmbB and EmbC Regulate the Sensitivity of<i>Mycobacterium abscessus</i>to Echinomycin
EmbB and EmbC Regulate the Sensitivity of<i>Mycobacterium abscessus</i>to Echinomycin Open
Treatment of Mycobacterium abscessus (Mab) infection is a major challenge due to its intrinsic resistance to most available drugs. It is thus imperative to find new anti-Mab drugs. In this study, we investigated the activity and intrinsic …
View article: Mutations in ClpC1 or ClpX subunit of the caseinolytic protease confer resistance to natural product ilamycins in mycobacteria
Mutations in ClpC1 or ClpX subunit of the caseinolytic protease confer resistance to natural product ilamycins in mycobacteria Open
The mycobacterial caseinolytic protease (Clp) system has been recognized as a promising therapeutic target. In this study, we identified two novel ilamycin analogs, ilamycin E (ILE) and ilamycin F (ILF), both targeting the ClpC1 component …
View article: A CRISPR-Nonhomologous End-Joining-based strategy for rapid and efficient gene disruption in<i>Mycobacterium abscessus</i>
A CRISPR-Nonhomologous End-Joining-based strategy for rapid and efficient gene disruption in<i>Mycobacterium abscessus</i> Open
Mycobacterium abscessus , a fast-growing, non-tuberculous mycobacterium resistant to most antimicrobial drugs, causes many types of serious infections in humans, posing a significant public health challenge. Currently, effective genetic ma…
View article: Molecular mechanisms of resistance and treatment efficacy of clofazimine and bedaquiline against Mycobacterium tuberculosis
Molecular mechanisms of resistance and treatment efficacy of clofazimine and bedaquiline against Mycobacterium tuberculosis Open
Clofazimine (CFZ) and bedaquiline (BDQ) are currently used for the treatment of multidrug-resistant (MDR) Mycobacterium tuberculosis ( Mtb ) strains. In recent years, adding CFZ and BDQ to tuberculosis (TB) drug regimens against MDR Mtb st…
View article: Comparative genome analysis reveals high-level drug resistance markers in a clinical isolate of Mycobacterium fortuitum subsp. fortuitum MF GZ001
Comparative genome analysis reveals high-level drug resistance markers in a clinical isolate of Mycobacterium fortuitum subsp. fortuitum MF GZ001 Open
Introduction Infections caused by non-tuberculosis mycobacteria are significantly worsening across the globe. M. fortuitum complex is a rapidly growing pathogenic species that is of clinical relevance to both humans and animals. This patho…
View article: A recombinant <i>Mycobacterium smegmatis</i> -based surface display system for developing the T cell-based COVID-19 vaccine
A recombinant <i>Mycobacterium smegmatis</i> -based surface display system for developing the T cell-based COVID-19 vaccine Open
The immune escape mutations of SARS-CoV-2 variants emerged frequently, posing a new challenge to weaken the protective efficacy of current vaccines. Thus, the development of novel SARS-CoV-2 vaccines is of great significance for future epi…
View article: Characterization of Genetic Variants Associated with Rifampicin Resistance Level in Mycobacterium tuberculosis Clinical Isolates Collected in Guangzhou Chest Hospital, China
Characterization of Genetic Variants Associated with Rifampicin Resistance Level in Mycobacterium tuberculosis Clinical Isolates Collected in Guangzhou Chest Hospital, China Open
Our findings underscore the key role of RRDR mutations and the contribution of non-RRDR mutations in rapid molecular diagnosis of RIFR clinical isolates. Such insights will support early detection of disease and recommend the appropriate a…
View article: Arabinosyltransferase C Mediates Multiple Drugs Intrinsic Resistance by Altering Cell Envelope Permeability in Mycobacterium abscessus
Arabinosyltransferase C Mediates Multiple Drugs Intrinsic Resistance by Altering Cell Envelope Permeability in Mycobacterium abscessus Open
Mycobacterium abscessus is intrinsically resistant to most antibiotics, and treatment of its infections is highly challenging. The mechanisms of its intrinsic resistance remain not fully understood.
View article: A recombinant selective drug-resistant<i>M. bovis</i>BCG enhances the bactericidal activity of a second-line tuberculosis regimen
A recombinant selective drug-resistant<i>M. bovis</i>BCG enhances the bactericidal activity of a second-line tuberculosis regimen Open
Drug-resistant tuberculosis (DR-TB) results from infection by Mycobacterium tuberculosis strains resistant to at least rifampin or isoniazid. To improve the treatment outcome in DR-TB, therapeutic vaccines are considered an ideal choice as…
View article: <p>Detection of Novel Gene Mutations Associated with Pyrazinamide Resistance in Multidrug-Resistant <em>Mycobacterium tuberculosis</em> Clinical Isolates in Southern China</p>
Detection of Novel Gene Mutations Associated with Pyrazinamide Resistance in Multidrug-Resistant <em>Mycobacterium tuberculosis</em> Clinical Isolates in Southern China Open
Our study revealed that PZAR rate in MDR and pre-XDR TB was markedly higher in southern China. The concomitant evaluation of pncA + UFR, rpsA, panD, Rv2783c, and Rv2044c provides more dependable genotypic results of PZA resistance. Fifty-s…
View article: Comparative Analysis of Whole-Genome and Methylome Profiles of a Smooth and a Rough <i>Mycobacterium abscessus</i> Clinical Strain
Comparative Analysis of Whole-Genome and Methylome Profiles of a Smooth and a Rough <i>Mycobacterium abscessus</i> Clinical Strain Open
Mycobacterium abscessus is a fast growing Mycobacterium species mainly causing skin and respiratory infections in human. M. abscessus is resistant to numerous drugs, which is a major challenge for the treatment. In this study, we have sequ…
View article: Discovery of (3-Benzyl-5-hydroxyphenyl)carbamates as New Antitubercular Agents with Potent In Vitro and In Vivo Efficacy
Discovery of (3-Benzyl-5-hydroxyphenyl)carbamates as New Antitubercular Agents with Potent In Vitro and In Vivo Efficacy Open
A series of 3-amino-5-benzylphenol derivatives were designed and synthesized. Among them, (3-benzyl-5-hydroxyphenyl)carbamates were found to exert good inhibitory activity against M. tuberculosis H37Ra, H37Rv and clinically isolated multid…
View article: Discovery of <i>meta</i>-Amido Bromophenols as New Antitubercular Agents
Discovery of <i>meta</i>-Amido Bromophenols as New Antitubercular Agents Open
A series of meta-amido bromophenol derivatives were designed and synthesized. The compounds were found to potently inhibit the growth of Mycobacterium tuberculosis H37Ra. They also exhibited moderate inhibitory activity against Mycobacteri…