Chen Cai
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View article: Expert consensus on disease-based long-term follow-up care plans for childhood cancer survivors
Expert consensus on disease-based long-term follow-up care plans for childhood cancer survivors Open
Background Childhood cancer survivors (CCSs) are at increased risk of long-term treatment-related complications. Although international guidelines support risk-based long-term follow-up (LTFU) care, its standardized implementation in China…
View article: Impact of exposure of particulate matters on stroke risk: exploring the influence of physical activity among middle-aged and older adults in China
Impact of exposure of particulate matters on stroke risk: exploring the influence of physical activity among middle-aged and older adults in China Open
Background Particulate matter is increasingly recognized as a critical environmental risk factor for stroke, particularly among older populations. Although physical activity confers substantial cerebrovascular benefits, it remains unclear …
View article: Spinal cord metastasis in a long‑term survivor of primary malignant glioblastoma: A case report
Spinal cord metastasis in a long‑term survivor of primary malignant glioblastoma: A case report Open
Glioblastoma (GBM) is the most common type of primary malignant brain tumor. Extracranial metastasis (ECM) is rare and usually indicates poor prognosis. We report a case of a 31-year-old female with GBM who underwent gross total resection …
View article: The Characteristics and Estimation of Greenhouse Gas Emissions from Urban Sewer Systems in Southern China
The Characteristics and Estimation of Greenhouse Gas Emissions from Urban Sewer Systems in Southern China Open
Carbon emission fluxes in urban sewer systems and the microbial community structure in sewer sediments remain unclear. In this study, a sewer system located in southern China was utilized to investigate the water quality characteristics. T…
View article: Application of a biofilm-enhanced A2O system in the treatment of wastewater from mariculture
Application of a biofilm-enhanced A2O system in the treatment of wastewater from mariculture Open
Development of environment-friendly and efficient aquaculture effluent treatment system is crucial for sustainable intensification of aquaculture, in the face of the rapidly increasing environmental pressure in the mariculture industry. In…
View article: Integrating multiple microarray datasets to explore the significance of ferroptosis regulators in the diagnosis and subtype classification of osteoarthritis
Integrating multiple microarray datasets to explore the significance of ferroptosis regulators in the diagnosis and subtype classification of osteoarthritis Open
Osteoarthritis (OA) is a chronic joint disease that reduces quality of life for patients. Ferroptosis plays a significant role in OA. However, its underlying mechanism remains unclear. In this study, we integrated 7 OA synovial datasets fr…
View article: Intestinal BMP-9 locally upregulates FGF19 and is down-regulated in obese patients with diabetes
Intestinal BMP-9 locally upregulates FGF19 and is down-regulated in obese patients with diabetes Open
Bone morphogenetic protein (BMP)-9, a member of the TGFβ-family of cytokines, is believed to be mainly produced in the liver. The serum levels of BMP-9 were reported to be reduced in newly diagnosed diabetic patients and BMP-9 overexpressi…
View article: Deciphering the Role of Melatonin-Related Signatures in Tumor Immunity and the Prognosis of Clear Cell Renal Cell Carcinoma
Deciphering the Role of Melatonin-Related Signatures in Tumor Immunity and the Prognosis of Clear Cell Renal Cell Carcinoma Open
Rationale. Recent research has suggested that melatonin-related regulators play crucial roles in solid cancers and may be new targets for cancers. However, the characteristics and roles of melatonin modulators in clear cell renal cell carc…
View article: Integrating multiple microarray datasets to explore the significance of ferroptosis regulators in the diagnosis and subtype classification of osteoarthritis
Integrating multiple microarray datasets to explore the significance of ferroptosis regulators in the diagnosis and subtype classification of osteoarthritis Open
Background Osteoarthritis (OA) is a prevalent chronic joint disease that reduces the quality of life. Ferroptosis plays a significant part in various biological processes. However, uncertainty surrounds the mechanism of action that underly…
View article: Trends and Correlation Between Antimicrobial Resistance and Antibiotics Consumption in a Specialist Children’s Hospital from 2016 to 2021
Trends and Correlation Between Antimicrobial Resistance and Antibiotics Consumption in a Specialist Children’s Hospital from 2016 to 2021 Open
Wenting Gong,1,* Wen Tang,2,* Lan Luo,3 Furong Zhang,1 Chenyang Cai,1 Jiangyan Zhang,1 Xiaolin Wu,4 Jianping Shang,4 Xiaolan Shu,2 Ting Wang,5 Danna Tu,6 Zhengjiang Jin,7,* Ronghao Zheng4,* 1Department of pharmacy, Maternal and Child Healt…
View article: Mechanistic Insights Into Co-Administration of Allosteric and Orthosteric Drugs to Overcome Drug-Resistance in T315I BCR-ABL1
Mechanistic Insights Into Co-Administration of Allosteric and Orthosteric Drugs to Overcome Drug-Resistance in T315I BCR-ABL1 Open
Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm, driven by the BCR-ABL1 fusion oncoprotein. The discovery of orthosteric BCR-ABL1 tyrosine kinase inhibitors (TKIs) targeting its active ATP-binding pocket, such as first-gene…
View article: Gemcitabine and XCT790, an ERRα inverse agonist, display a synergistic anticancer effect in pancreatic cancer
Gemcitabine and XCT790, an ERRα inverse agonist, display a synergistic anticancer effect in pancreatic cancer Open
Pancreatic cancer (PC) is one of the most fatal and chemoresistant malignancies with a poor prognosis. The current therapeutic options for PC have not achieved satisfactory results due to drug resistance. Therefore, it is urgent to develop…
View article: Identification of liver‐derived bone morphogenetic protein (BMP)‐9 as a potential new candidate for treatment of colorectal cancer
Identification of liver‐derived bone morphogenetic protein (BMP)‐9 as a potential new candidate for treatment of colorectal cancer Open
Colorectal cancer (CRC) is a high‐incidence malignancy worldwide which still needs better therapy options. Therefore, the aim of the present study was to investigate the responses of normal or malignant human intestinal epithelium to bone …
View article: Triptolide Attenuates Neuropathic Pain by Regulating Microglia Polarization through the CCL2/CCR2 Axis
Triptolide Attenuates Neuropathic Pain by Regulating Microglia Polarization through the CCL2/CCR2 Axis Open
Triptolide (T10) is a common anti-inflammatory and analgesic drug. However, the activation of microglia and elimination of the corresponding inflammatory response are new targets for the treatment of neuropathic pain. Chemokine CCL (CCL2) …
View article: SINE Insertion in 5’ Flanking of Porcine IGFBP3 May Associated with Gene Expression and Phenotypic Variations
SINE Insertion in 5’ Flanking of Porcine IGFBP3 May Associated with Gene Expression and Phenotypic Variations Open
Background: Insulin-like growth factor binding proteins (IGFBPs) have been considered important candidate genes for economic traits due to their involvement in physiological processes related to growth and development. However, most of the…
View article: Preoperative serum fibrinogen as a valuable predictor in the nomogram predicting overall survival of postoperative patients with gallbladder cancer
Preoperative serum fibrinogen as a valuable predictor in the nomogram predicting overall survival of postoperative patients with gallbladder cancer Open
The validated nomogram is a practical tool for predicting the overall survival (OS) of postoperative GBC patients. Preoperative serum fibrinogen levels were associated with tumor progression and may be an independent predictor for GBC pati…
View article: SINE Insertion in 5’ Flanking of IGFBP3 May Associated With Gene Expression and Phenotypic Variations
SINE Insertion in 5’ Flanking of IGFBP3 May Associated With Gene Expression and Phenotypic Variations Open
Background: Insulin-like growth factor binding proteins (IGFBPs), specifically binding to IGF1 and IGF2, play an important role in regulating physiological functions of insulin-like growth factors (IGFs). IGFBPs have been considered import…
View article: Potential Association Between Asthma, Helicobacter pylori Infection, and Gastric Cancer
Potential Association Between Asthma, Helicobacter pylori Infection, and Gastric Cancer Open
Background: The prevalence of Helicobacter pylori infection (HPI) is still high around the world, which induces gastric diseases, such as gastric cancer (GC). The epidemiological investigation showed that there was an association between H…
View article: BMP-9 Modulates the Hepatic Responses to LPS
BMP-9 Modulates the Hepatic Responses to LPS Open
It was previously shown that Bone Morphogenetic Protein (BMP)-9 is constitutively produced and secreted by hepatic stellate cells (HSC). Upon acute liver damage, BMP-9 expression is transiently down-regulated and blocking BMP-9 under condi…
View article: Development of enhancer-trapping and -detection vectors mediated by the<i>Tol2</i>transposon in zebrafish
Development of enhancer-trapping and -detection vectors mediated by the<i>Tol2</i>transposon in zebrafish Open
Enhancers are key transcriptional drivers of gene expression. The identification of enhancers in the genome is central for understanding gene-expression programs. Although transposon-mediated enhancer trapping (ET) is a powerful approach t…
View article: Efficacy and safety of cycloserine-containing regimens in the treatment of multidrug-resistant tuberculosis: a nationwide retrospective cohort study in China
Efficacy and safety of cycloserine-containing regimens in the treatment of multidrug-resistant tuberculosis: a nationwide retrospective cohort study in China Open
Jing Wang,1* Yu Pang,2* Wei Jing,1* Wei Chen,1* Ru Guo,1* Xiqin Han,1 Limin Wu,3 Guangxu Yang,4 Kunyun Yang,5 Cong Chen,6 Lin Jiang,7 Chunkui Cai,8 Zhi Dou,9 Lijuan Diao,10 Hongqiu Pan,11 Jianyun Wang,12 Feifei Du,13 Tao Xu,14 Lixia Wang,1…
View article: Enhancer Trapping and Annotation in Zebrafish Mediated with Sleeping Beauty, piggyBac and Tol2 Transposons
Enhancer Trapping and Annotation in Zebrafish Mediated with Sleeping Beauty, piggyBac and Tol2 Transposons Open
Although transposon-mediated enhancer trapping (ET) is successfully applied in diverse models, the efficiency of various transposon systems varies significantly, and little information is available regarding efficiency of enhancer trapping…
View article: Classification of triple-negative breast cancers based on Immunogenomic profiling
Classification of triple-negative breast cancers based on Immunogenomic profiling Open
The identification of TNBC subtypes based on immune signatures has potential clinical implications for TNBC treatment.
View article: Changes in Skeletal Muscle and Body Weight on Sleeping Beauty Transposon-Mediated Transgenic Mice Overexpressing Pig mIGF-1
Changes in Skeletal Muscle and Body Weight on Sleeping Beauty Transposon-Mediated Transgenic Mice Overexpressing Pig mIGF-1 Open
Insulin-like growth factor (IGF-I) is an important growth factor in mammals, but the functions of the local muscle-specific isoform of insulin-like growth factor 1 (mIGF-1) to skeletal muscle development have rarely been reported. To deter…