Cuiyan Zhou
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View article: The S1′–S3′ Pocket of the SARS‐CoV‐2 Main Protease Is Critical for Substrate Selectivity and Can Be Targeted with Covalent Inhibitors
The S1′–S3′ Pocket of the SARS‐CoV‐2 Main Protease Is Critical for Substrate Selectivity and Can Be Targeted with Covalent Inhibitors Open
The main protease (M pro ) of SARS‐CoV‐2 is a well‐characterized target for antiviral drug discovery. To date, most antiviral drug discovery efforts have focused on the S4–S1′ pocket of M pro ; however, it is still unclear whether the S1′–…
View article: Malate-Aspartate Shuttle Plays an Important Role in LPS-Induced Neuroinflammation of Mice Due to its Effect on STAT3 Phosphorylation
Malate-Aspartate Shuttle Plays an Important Role in LPS-Induced Neuroinflammation of Mice Due to its Effect on STAT3 Phosphorylation Open
Neuroinflammation is a key pathological factor in numerous neurological disorders. Cumulating evidence has indicated critical roles of NAD + /NADH metabolism in multiple major diseases, while the role of malate-aspartate shuttle (MAS) - a …
View article: Peer Review #1 of "Oxidative stress induces cell death partially by decreasing both mRNA and protein levels of nicotinamide phosphoribosyltransferase in differentiated PC12 cells (v0.1)"
Peer Review #1 of "Oxidative stress induces cell death partially by decreasing both mRNA and protein levels of nicotinamide phosphoribosyltransferase in differentiated PC12 cells (v0.1)" Open
Background.Multiple studies have indicated crucial roles of NAD + deficiency in several neurological diseases and aging.It is critical to discover the mechanisms underlying the NAD + deficiency.Decreased level of Nicotinamide phosphoribosy…
View article: Peer Review #1 of "Oxidative stress induces cell death partially by decreasing both mRNA and protein levels of nicotinamide phosphoribosyltransferase in differentiated PC12 cells (v0.2)"
Peer Review #1 of "Oxidative stress induces cell death partially by decreasing both mRNA and protein levels of nicotinamide phosphoribosyltransferase in differentiated PC12 cells (v0.2)" Open
Background.Multiple studies have indicated crucial roles of NAD + deficiency in several neurological diseases and aging.It is critical to discover the mechanisms underlying the NAD + deficiency.Decreased level of Nicotinamide phosphoribosy…
View article: Oxidative stress induces cell death partially by decreasing both mRNA and protein levels of nicotinamide phosphoribosyltransferase in differentiated PC12 cells
Oxidative stress induces cell death partially by decreasing both mRNA and protein levels of nicotinamide phosphoribosyltransferase in differentiated PC12 cells Open
Background. Multiple studies have indicated crucial roles of NAD + deficiency in several neurological diseases and aging. It is critical to discover the mechanisms underlying the NAD + deficiency. A decreased level of Nicotinamide phosphor…
View article: Oxidative stress induces cell death partially by decreasing both mRNA and protein levels of nicotinamide phosphoribosyltransferase in PC12 cells
Oxidative stress induces cell death partially by decreasing both mRNA and protein levels of nicotinamide phosphoribosyltransferase in PC12 cells Open
Numerous studies have indicated critical roles of NAD + deficiency in both aging and multiple major diseases. It is critical to investigate the mechanisms underlying the NAD + deficiency under the pathological conditions. It has been repor…
View article: Cryo-EM structure of C9ORF72-SMCR8-WDR41 reveals the role as a GAP for Rab8a and Rab11a
Cryo-EM structure of C9ORF72-SMCR8-WDR41 reveals the role as a GAP for Rab8a and Rab11a Open
A massive intronic hexanucleotide repeat (GGGGCC) expansion in C9ORF72 is a genetic origin of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Recently, C9ORF72, together with SMCR8 and WDR41, has been shown to regula…
View article: Cryo-EM structure of C9ORF72–SMCR8–WDR41 reveals the role as a GAP for Rab8a and Rab11a
Cryo-EM structure of C9ORF72–SMCR8–WDR41 reveals the role as a GAP for Rab8a and Rab11a Open
A massive intronic hexanucleotide repeat (GGGGCC) expansion in C9ORF72 is a genetic origin of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Recently, C9ORF72, together with SMCR8 and WDR41, has been shown to regula…
View article: Structural and functional insight into the effect of AFF4 dimerization on activation of HIV-1 proviral transcription
Structural and functional insight into the effect of AFF4 dimerization on activation of HIV-1 proviral transcription Open
Super elongation complex (SEC) is a positive regulator of RNA polymerase II, which is required for HIV-1 proviral transcription. AFF1/4 is the scaffold protein that recruits other components of SEC and forms dimer depending on its THD doma…
View article: Mitochondrial Electron Transport Chain Inhibition Suppresses LPS-Induced Inflammatory Responses via TREM1/STAT3 Pathway in BV2 Microglia
Mitochondrial Electron Transport Chain Inhibition Suppresses LPS-Induced Inflammatory Responses via TREM1/STAT3 Pathway in BV2 Microglia Open
Mitochondrial damage and neuroinflammation belong to two of the most important pathological factors in multiple neurological disorders. However, the effect of mitochondrial damage of microglia on microglial activation under pathological co…
View article: Involvement of budding yeast Rad5 in translesion DNA synthesis through physical interaction with Rev1
Involvement of budding yeast Rad5 in translesion DNA synthesis through physical interaction with Rev1 Open
DNA damage tolerance (DDT) is responsible for genomic stability and cell viability by bypassing the replication block. In Saccharomyces cerevisiae DDT employs two parallel branch pathways to bypass the DNA lesion, namely translesion DNA sy…